Symbolic non-synonymous single nucleotide variants (SNVs) of both the <i>TP53</i> gene (P33R) in each single aneuploid CTCs, and the cyclin-dependent kinase inhibitor 2A (<i>CDKN2A</i>) tumor suppressor gene in each examined aneuploid CECs, were identified for the first time across patients with diverse carcinomas.
Deletion of Ink4a/Arf in K-ras(G12D) expressing mice prevents senescence and leads to invasive, metastasizing carcinomas with morphological and molecular alterations comparable to human KRAS mutated serrated tumors.