| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.030 | GeneticVariation | BEFREE | More importantly, DNA methylation was significantly higher in Arg/Arg when compared to Pro/Pro genotype carriers at codon 72 rs1042522 of TP53 (65% vs 20% methylated loci, p = 0.0006), a polymorphism already known to affect somatic mutation rate in human carcinomas. | 25889455 | 2015 |
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0.030 | GeneticVariation | BEFREE | Meta-analysis of associations between the TP53 Arg72Pro polymorphism with risk of head and neck carcinomas based on case-control studies. | 24446292 | 2014 |
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|
0.030 | GeneticVariation | BEFREE | A common single nucleotide repeat (snp) in exon 3 (rs1042522) and deletion sequencing chromatograms in exon 4 were examined in combination to estimate LOH in both LFS tubes and advanced serous carcinomas from the general population. | 19834951 | 2010 |
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|
0.010 | GeneticVariation | BEFREE | Meta-analysis of associations between the TP53 Arg72Pro polymorphism with risk of head and neck carcinomas based on case-control studies. | 24446292 | 2014 |
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|
0.010 | GeneticVariation | BEFREE | Meta-analysis of associations between the TP53 Arg72Pro polymorphism with risk of head and neck carcinomas based on case-control studies. | 24446292 | 2014 |
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|
0.010 | GeneticVariation | BEFREE | Screening for the p.R337H mutation identified 11 carriers (3.7%), 9 of whom were diagnosed with adrenocortical carcinomas (ACC) and 2 of whom were diagnosed with choroid plexus carcinomas. | 24122735 | 2013 |
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0.010 | GeneticVariation | BEFREE | Two variants of E6 proteins, D25E and L83V, are common in cervical carcinomas among Asian and European populations. | 23404471 | 2013 |
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0.010 | GeneticVariation | BEFREE | Two variants of E6 proteins, D25E and L83V, are common in cervical carcinomas among Asian and European populations. | 23404471 | 2013 |
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0.010 | GeneticVariation | BEFREE | A homozygous p53 R248W gain-of-function mutation as the result of a CGG to TGG transition was identified in one of seven sebaceous gland carcinomas. | 18717684 | 2008 |