|
rs12490683
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping studies identified two MYLKP1 SNPs (rs12490683; rs12497343) that significantly increase risk of colon cancer in African Americans compared to African American controls.
|
30161129 |
2018 |
|
rs12497343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping studies identified two MYLKP1 SNPs (rs12490683; rs12497343) that significantly increase risk of colon cancer in African Americans compared to African American controls.
|
30161129 |
2018 |
|
rs12778366
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Sex- and subsite-specific Cox hazard ratios (HRs) showed that the rs12778366 CC versus TT genotype decreased CRC and colon cancer risks in women (HR<sub>CRC</sub> = 0.53, 95% confidence interval: 0.30-0.94) but not men.
|
30410074 |
2018 |
|
rs1383147053
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the anti-proliferative effect of miR-143#12 and the mechanism in human colon cancer DLD-1 cell (G13D) and other cell types harboring K-Ras mutations.
|
29498789 |
2018 |
|
rs147740818
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Colon cancers carrying BRAF V600E and β-catenin T41A activating mutations are resistant to numerous common anticancer drugs.
|
29541216 |
2018 |
|
rs16840252
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, we found the CTLA-4 rs16840252 C>T polymorphism was associated with the risk of colon cancer.
|
30122952 |
2018 |
|
rs1799853
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Site-specific analysis showed association between SNPs rs1799853 and rs2302615 with reduced colon cancer risk only (P = 0.01 and P = 0.004, respectively), however neither reached significance threshold following multiple test correction.
|
29425227 |
2018 |
|
rs2302615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Site-specific analysis showed association between SNPs rs1799853 and rs2302615 with reduced colon cancer risk only (P = 0.01 and P = 0.004, respectively), however neither reached significance threshold following multiple test correction.
|
29425227 |
2018 |
|
rs283415
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In female drinkers, ADH1C rs283415 increased proximal colon cancer risk.
|
29390059 |
2018 |
|
rs3804100
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Real-time PCR and immunohistochemistry were used to investigate <i>TLR2</i> gene expression and to evaluate the potential risk of predisposition to colon cancer caused by three tagging single-nucleotide polymorphisms (SNPs) on <i>TLR2</i>, including rs3804100, rs4696480, and rs3804099.
|
30532554 |
2018 |
|
rs3811802
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ADH1B rs3811802 and ADH1C rs4147542 significantly modified the alcohol-colon cancer association in women.
|
29390059 |
2018 |
|
rs4147536
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In male drinkers, ADH1B rs4147536 increased (distal) colon cancer risk.
|
29390059 |
2018 |
|
rs4147542
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ADH1B rs3811802 and ADH1C rs4147542 significantly modified the alcohol-colon cancer association in women.
|
29390059 |
2018 |
|
rs4696480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, <i>TLR2</i> rs4696480 appear to be not involved in colon cancer in our study population.
|
30532554 |
2018 |
|
rs730881834
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report a MUTYH variant, p.C306W (c.918C>G), with a tryptophan residue in place of native cysteine, that ligates the [4Fe4S] cluster in a patient with colonic polyposis and family history of early age colon cancer.
|
29915346 |
2018 |
|
rs752021744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the anti-proliferative effect of miR-143#12 and the mechanism in human colon cancer DLD-1 cell (G13D) and other cell types harboring K-Ras mutations.
|
29498789 |
2018 |
|
rs773442580
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, EGF‑ETA was just as potent in HCT116 (KRAS G13D) and SW480 (KRAS G12V) colon cancer cell lines harbouring KRAS hyperactivating mutations when compared to KRAS wild‑type HT29 colon cancer cells.
|
30226622 |
2018 |
|
rs10222633
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis within linkage blocks of CASR revealed the G-G-G-G-G-A-C haplotype (rs10222633-rs10934578-rs3804592-rs17250717-A986S-R990G-rs1802757) to be associated with a decreased OS of colon cancer (HR, 3.15; 95% CI, 1.66-5.96).
|
28765616 |
2017 |
|
rs1042636
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis within linkage blocks of CASR revealed the G-G-G-G-G-A-C haplotype (rs10222633-rs10934578-rs3804592-rs17250717-A986S-R990G-rs1802757) to be associated with a decreased OS of colon cancer (HR, 3.15; 95% CI, 1.66-5.96).
|
28765616 |
2017 |
|
rs17250717
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis within linkage blocks of CASR revealed the G-G-G-G-G-A-C haplotype (rs10222633-rs10934578-rs3804592-rs17250717-A986S-R990G-rs1802757) to be associated with a decreased OS of colon cancer (HR, 3.15; 95% CI, 1.66-5.96).
|
28765616 |
2017 |
|
rs1799929
|
|
|
0.010 |
GeneticVariation |
BEFREE |
High fried red meat intake associated with NAT2-T341C, G590A, G857A, A845C, and C48</span>1T rapid acetylator allele determines a risk of 2.39 (P=.002), 2.39 (P=.002), 2.37 (P=.002), 2.28 (P=.004), and 2.51 (P=.001), respectively, for colon cancer, whereas in the case of rectal cancer, the risk increased to 7.55 (P<.001), 7.7 (P<.001), 7.83 (P<.001), 7.51 (P<.001), and 8.62 (P<.001), respectively.
|
27883249 |
2017 |
|
rs1800734
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our aim was to determine the effect of the single nucleotide polymorphisms (SNP) -93G>A of the MLH1 gene (rs1800734) and Gly322Asp of the MSH2 gene (rs4987188) on the risk of colon cancer (CC) and identify any relationship with clinical factors.
|
29181059 |
2017 |
|
rs1801133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, <i>MTHFR</i> rs1801133 G>A polymorphism conferred a decreased risk to colon cancer.
|
28969008 |
2017 |
|
rs1801725
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis within linkage blocks of CASR revealed the G-G-G-G-G-A-C haplotype (rs10222633-rs10934578-rs3804592-rs17250717-A986S-R990G-rs1802757) to be associated with a decreased OS of colon cancer (HR, 3.15; 95% CI, 1.66-5.96).
|
28765616 |
2017 |
|
rs1802757
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis within linkage blocks of CASR revealed the G-G-G-G-G-A-C haplotype (rs10222633-rs10934578-rs3804592-rs17250717-A986S-R990G-rs1802757) to be associated with a decreased OS of colon cancer (HR, 3.15; 95% CI, 1.66-5.96).
|
28765616 |
2017 |