|
rs25487
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In this study, we attempted to assess the association between XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms and risk of laryngeal cancer in a Chinese population.
|
27808358 |
2016 |
|
rs25487
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Overall, our results found that only AA genotype of the XRCC1 gene Arg399Gln polymorphism under the homozygous model was associated with increased the risk of patients with laryngeal cancer (AA vs. GG: OR=1.29, 95% CI=1.00-1.65, P=0.05).
|
26898429 |
2016 |
|
rs861539
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association between polymorphisms of XRCC1 Arg399Gln, XRCC3 Thr241Met, and XPD Lys751Gln and laryngeal cancer risk.
|
26898429 |
2016 |
|
rs11615
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, our study showed that ERCC1 rs11615 and ERCC2 rs50871 polymorphisms could influence the risk of larynx cancer in Chinese population, particularly among smokers.
|
26617899 |
2015 |
|
rs861539
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The genotype and allele frequencies of Thr241Met polymorphism were not statistically significant between the l</span>aryngeal cancer and control groups.
|
25510985 |
2015 |
|
rs11615
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, our study suggests that ERCC1 rs11615 and ERCC5 rs17655 polymorphisms are associated with increased risk of laryngeal cancer, and that they confer more risk among smokers and drinkers.
|
24582975 |
2014 |
|
rs11615
|
|
|
0.030 |
GeneticVariation |
BEFREE |
By stratified analysis, ERCC1 rs11615 CC genotype and C allele were significantly associated with greatly increased risk of laryngeal cancer in ever smokers.
|
24563277 |
2014 |
|
rs25487
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Therefore, we concluded that XRCC1 gene Arg399Gln polymorphism was not associated with laryngeal cancer.
|
24194393 |
2014 |
|
rs861539
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The present study indicated that XRCC3 gene C722T polymorphism was not associated with larynx cancer.
|
24523020 |
2014 |
|
rs61754966
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We have previously shown that the p.I171V NBN gene mutation may contribute to the development of laryngeal cancer.
|
24079363 |
2013 |
|
rs61754966
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Positive associations have also been reported for leukaemia and larynx cancer suggesting that I171V could be a more general susceptibility factor for malignancies.
|
18049891 |
2008 |
|
rs61754966
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These findings imply that heterozygous carriers of the I171V mutation are prone to the development of larynx cancer and may, in addition, display an increased risk of second tumors at other sites.
|
17894553 |
2007 |
|
rs13181
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This significant relationship was not detected between XRCC3 Thr241Met, XPD Lys751Gln polymorphisms and laryngeal cancer risk (P>0.05).
|
26898429 |
2016 |
|
rs1056827
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We also found that CYP1B1 rs1056827 polymorphism had synergistic effects with smoking or alcohol consumption regarding the risk of laryngeal cancer.
|
25619313 |
2015 |
|
rs1056827
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Effects of SNPs (CYP1B1*2 G355T, CYP1B1*3 C4326G, and CYP2E1*5 G-1293C), smoking, and drinking on susceptibility to laryngeal cancer among Han Chinese.
|
25299224 |
2014 |
|
rs13181
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, XPD Lys751Gln polymorphism was significantly associated with susceptibility to LC and NPC and the Lys allele and Lys/Lys genotype of XPD Lys751Gln polymorphism may be a risk factor for LC and NPC.
|
24443924 |
2014 |
|
rs17655
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In summary, we suggest that genetic variations in ERCC1 rs11615 and ERCC5 rs17655 are associated with laryngeal cancer risk in a Chinese population, especially in ever smokers and drinkers.
|
24563277 |
2014 |
|
rs17655
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Similarly, individuals with the ERCC5 rs17655 GG genotype and G allele had an increased risk of laryngeal cancer.
|
24582975 |
2014 |
|
rs1816158
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Joint population analyses identified novel miR-SNPs associated with overall survival in oral and laryngeal cancers. rs1816158, located within long noncoding RNA <i>MIR100HG</i>, was associated with overall survival in oral cavity cancer (HR, 1.56; 95% confidence interval (CI), 1.21-2.00).
|
29880533 |
2019 |
|
rs56161233
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A SNP in the 3'UTR of <i>SH3BP4</i> (rs56161233) that overlaps predicted miRNA-binding sites and is predicted to disrupt several miRNA-mRNA interactions was associated with overall survival of laryngeal cancer (HR, 2.57; 95% CI, 1.71-3.86).
|
29880533 |
2019 |
|
rs6877842
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In stratified analysis, correlations of <i>DROSHA</i> rs10719 and rs6877842 SNPs were observed in Asian and laryngeal cancer subgroups, respectively.
|
29654164 |
2018 |
|
rs148704956
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the rs2275913 IL-17A (197 G/A) is associated with the incidence and development of laryngeal cancer in the Chinese population, and the AA and GA+AA genotypes harbor a high laryngeal cancer risk.
|
28362993 |
2017 |
|
rs1864183
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found an association between the variant in ATG10 rs1864183 and a higher susceptibility to develop laryngeal cancer, ATG2B rs3759601 and pharyngeal cancer and ATG16L1 rs2241880 and oral carcinoma.
|
28761177 |
2017 |
|
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the rs227</span>5913 IL-17A (197 G/A) is associated with the incidence and development of laryngeal cancer in the Chinese population, and the AA and GA+AA genotypes harbor a high laryngeal cancer risk.
|
28362993 |
2017 |
|
rs4975616
|
|
|
0.010 |
GeneticVariation |
BEFREE |
3'UTR variant of HADH, rs221347 and rs4975616, located within known cancer risk locus 5p15.33, were specific to risk of laryngeal cancer.
|
28582492 |
2017 |