|
rs2189517
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs1800734 (in MLH1 gene) was associated with colon cancer risk (p-value = 3.5 × 10<sup>-6</sup> ) and rs2189517 (in RAD51B) with rectal cancer risk (p-value = 5.7 × 10<sup>-6</sup> ).
|
31209889 |
2020 |
|
rs10484879
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Higher rs2275913 and rs10484879, and reduced rs3804513 MAF were seen in rectal cancer (RC) tolerant to FOLFOX (T+) compared to (T-) patients.
|
31138901 |
2019 |
|
rs187115
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we comprehensively examined the association between CD44 rs187115 variant and cancer risk (breast cancer, cervical cancer, lung cancer, gastric cancer, liver cancer, colon cancer, and rectal cancer) in a central Chinese population.
|
30860617 |
2019 |
|
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Higher rs2275913 and rs10484879, and reduced rs3804513 MAF were seen in rectal cancer (RC) tolerant to FOLFOX (T+) compared to (T-) patients.
|
31138901 |
2019 |
|
rs2632159
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A more pronounced effect was observed in the male subgroup in that <i>PCAT1</i> rs2632159 SNP increased rectal cancer risk by 3.97-fold (<i>P</i>=0.017).
|
31253700 |
2019 |
|
rs3748067
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Strong association of rs3819025, rs3804513, and rs7747909 was found with tolerance to RC treatment. rs3748067 was associated with FOLFOX tolerance in CC but not RC.
|
31138901 |
2019 |
|
rs3804513
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Strong association of rs3819025, rs3804513, and rs7747909 was found with tolerance to RC treatment. rs3748067 was associated with FOLFOX tolerance in CC but not RC.
|
31138901 |
2019 |
|
rs5743030
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, PMS1 rs4920657, rs5743030, and rs5743100 were associated with overall survival (OS) time of rectal cancer.
|
30590005 |
2019 |
|
rs5743100
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, PMS1 rs4920657, rs5743030, and rs5743100 were associated with overall survival (OS) time of rectal cancer.
|
30590005 |
2019 |
|
rs6983267
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We confirmed that the homozygous T/T allele of rs6983267 c-MYC indicated an interaction between dietary seaweed intake and both overall CRC and rectal cancer (CRC OR [95% CI] = 0.52 [0.34-0.81], P for interaction = 0.015; rectal cancer = 0.45 [0.25-0.79], P for interaction = 0.007, T/T carriers with high total seaweed intake vs. T/T carriers with low total seaweed intake).
|
31300834 |
2019 |
|
rs7747909
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Strong association of rs3819025, rs3804513, and rs7747909 was found with tolerance to RC treatment. rs3748067 was associated with FOLFOX tolerance in CC but not RC.
|
31138901 |
2019 |
|
rs1143623
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the CC and/or GC genotype of rs1143623 polymorphism were correlated with decreased risk among CRC patients with tumor size ≥5cm, TNM stage III+IV, and rectal cancer.
|
30563955 |
2018 |
|
rs202195689
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that rs2273626 and rs202195689 in microRNA seed regions might serve as independent biomarkers for predicting AEs and prognosis in patients with rectal cancer receiving postoperative chemoradiation therapy.
|
29485044 |
2018 |
|
rs2273626
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that rs2273626 and rs202195689 in microRNA seed regions might serve as independent biomarkers for predicting AEs and prognosis in patients with rectal cancer receiving postoperative chemoradiation therapy.
|
29485044 |
2018 |
|
rs25531
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SERT gene promoter SNP rs25531 was associated with the CRF in patients with colon and rectal cancer and the G genotype was an independent risk factor for CRF among individuals with colon and rectal cancer in the study.
|
29551185 |
2018 |
|
rs763780
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When stratified by the <i>IL-17F</i> rs763780 genotype, this association was stronger for individuals carrying the C allele (<i>p</i> for interaction = 0.034), particularly for individuals with rectal cancer (<i>p</i> for interaction = 0.011).
|
29874787 |
2018 |
|
rs937283
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our case-control analysis revealed that rs937283 was associated with the susceptibility to breast and liver cancer, but not cervical, colon, or rectal cancer.
|
30244662 |
2018 |
|
rs956304
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore the correlation between the SERT gene promoter single nucleotide polymorphisms (SNPs) rs25531 and rs956304 and the cancer-related fatigue (CRF) of colon and rectal cancer, and also to analyze the correlation of the interaction of genetic and non-genetic factors.
|
29551185 |
2018 |
|
rs1052133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subgroup analyses revealed significant association of OGG1 rs1052133 with rectal cancer risk.
|
28749454 |
2017 |
|
rs1525489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, after stratification by histology (colon vs. rectum) we found that rs1525489 was associated with increased risk of rectal cancer with a (P<sub>trend</sub> of = 0.0071).
|
28915899 |
2017 |
|
rs17268122
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The screening of ABCC4 rs17268122 tagSNP and the Mandard tumor response in clinical practice may help to identify patients with different rectal cancer prognosis and contribute to an individualized therapeutic decision tree.
|
28011504 |
2017 |
|
rs1799929
|
|
|
0.010 |
GeneticVariation |
BEFREE |
High fried red meat intake associated with NAT2-T341C, G590A, G857A, A845C, and C48</span>1T rapid acetylator allele determines a risk of 2.39 (P=.002), 2.39 (P=.002), 2.37 (P=.002), 2.28 (P=.004), and 2.51 (P=.001), respectively, for colon cancer, whereas in the case of rectal cancer, the risk increased to 7.55 (P<.001), 7.7 (P<.001), 7.83 (P<.001), 7.51 (P<.001), and 8.62 (P<.001), respectively.
|
27883249 |
2017 |
|
rs1800471
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single Nucleotide Polymorphism TGFβ1 R25P Correlates with Acute Toxicity during Neoadjuvant Chemoradiotherapy in Rectal Cancer Patients.
|
28333014 |
2017 |
|
rs3753584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, a significantly increased risk of rectum cancer associated with <i>MTHFR</i> rs3753584 T>C polymorphism was overt.
|
28969008 |
2017 |
|
rs4646903
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers of the CYP1A1 rs4646903 CC homozygous variant showed a reduced risk of rectal cancer compared with that in TT carriers.
|
28273931 |
2017 |