Gene: BRAF ×
Source: INFERRED ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913355
rs121913355
BRAF
A 0.720 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913348
rs121913348
BRAF
A 0.700 CausalMutation CLINVAR Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines. 19593635

2010
dbSNP: rs121913348
rs121913348
BRAF
A 0.700 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913348
rs121913348
BRAF
A 0.700 CausalMutation CLINVAR Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines. 17314276

2007
dbSNP: rs121913351
rs121913351
BRAF
A 0.700 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913351
rs121913351
BRAF
A 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs121913351
rs121913351
BRAF
A 0.700 CausalMutation CLINVAR Missense mutations of the BRAF gene in human lung adenocarcinoma. 12460919

2002
dbSNP: rs121913378
rs121913378
BRAF
A 0.700 GeneticVariation CLINVAR High frequency of mutations of the PIK3CA gene in human cancers. 15016963

2004
dbSNP: rs121913378
rs121913378
BRAF
A 0.700 GeneticVariation CLINVAR Inactivation of the mitogen-activated protein kinase pathway as a potential target-based therapy in ovarian serous tumors with KRAS or BRAF mutations. 15753399

2005
dbSNP: rs121913338
rs121913338
BRAF
C 0.700 CausalMutation CLINVAR Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas. 14688025

2004
dbSNP: rs121913364
rs121913364
BRAF
C 0.700 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913369
rs121913369
BRAF
C 0.700 CausalMutation CLINVAR A structural systems biology approach for quantifying the systemic consequences of missense mutations in proteins. 23093928

2012
dbSNP: rs121913369
rs121913369
BRAF
C 0.700 CausalMutation CLINVAR The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. 22892241

2012
dbSNP: rs121913369
rs121913369
BRAF
C 0.700 CausalMutation CLINVAR Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. 15035987

2004
dbSNP: rs121913369
rs121913369
BRAF
C 0.700 CausalMutation CLINVAR Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum. 19206169

2009
dbSNP: rs121913370
rs121913370
BRAF
C 0.700 GeneticVariation CLINVAR

dbSNP: rs121913355
rs121913355
BRAF
G 0.720 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs113488022
rs113488022
BRAF
T 0.800 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913357
rs121913357
BRAF
T 0.710 GeneticVariation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913353
rs121913353
BRAF
T 0.700 GeneticVariation CLINVAR Activating BRAF and N-Ras mutations in sporadic primary melanomas: an inverse association with allelic loss on chromosome 9. 14681681

2003
dbSNP: rs121913353
rs121913353
BRAF
T 0.700 GeneticVariation CLINVAR Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis. 15046639

2004
dbSNP: rs121913378
rs121913378
BRAF
T 0.700 GeneticVariation CLINVAR

dbSNP: rs397516890
rs397516890
BRAF
T 0.700 CausalMutation CLINVAR

dbSNP: rs397516896
rs397516896
BRAF
T 0.700 GeneticVariation CLINVAR Gene expression signature associated with BRAF mutations in human primary cutaneous melanomas. 19383316

2008
dbSNP: rs397516896
rs397516896
BRAF
T 0.700 GeneticVariation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002