Gene: BRAF ×
Source: INFERRED ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs113488022
rs113488022
BRAF
T 0.800 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913355
rs121913355
BRAF
A 0.720 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913355
rs121913355
BRAF
G 0.720 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913357
rs121913357
BRAF
T 0.710 GeneticVariation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913351
rs121913351
BRAF
A 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs121913369
rs121913369
BRAF
C 0.700 CausalMutation CLINVAR A structural systems biology approach for quantifying the systemic consequences of missense mutations in proteins. 23093928

2012
dbSNP: rs121913369
rs121913369
BRAF
C 0.700 CausalMutation CLINVAR The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. 22892241

2012
dbSNP: rs727502902
rs727502902
BRAF
TGTA 0.700 CausalMutation CLINVAR Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma. 22535154

2012
dbSNP: rs727502902
rs727502902
BRAF
TGTA 0.700 CausalMutation CLINVAR Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma. 21190184

2011
dbSNP: rs727502902
rs727502902
BRAF
TGTA 0.700 CausalMutation CLINVAR Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. 21343559

2011
dbSNP: rs727502902
rs727502902
BRAF
TGTA 0.700 CausalMutation CLINVAR BRAF, p53 and SOX2 in anaplastic thyroid carcinoma: evidence for multistep carcinogenesis. 21716161

2011
dbSNP: rs121913348
rs121913348
BRAF
A 0.700 CausalMutation CLINVAR Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines. 19593635

2010
dbSNP: rs397516896
rs397516896
BRAF
T 0.700 GeneticVariation CLINVAR KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy. 19913317

2010
dbSNP: rs121913369
rs121913369
BRAF
C 0.700 CausalMutation CLINVAR Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum. 19206169

2009
dbSNP: rs727502902
rs727502902
BRAF
TGTA 0.700 CausalMutation CLINVAR Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. 19794125

2009
dbSNP: rs727502902
rs727502902
BRAF
TGTA 0.700 CausalMutation CLINVAR Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma. 19363522

2009
dbSNP: rs397516896
rs397516896
BRAF
T 0.700 GeneticVariation CLINVAR Gene expression signature associated with BRAF mutations in human primary cutaneous melanomas. 19383316

2008
dbSNP: rs397516896
rs397516896
BRAF
T 0.700 GeneticVariation CLINVAR MC1R variants increase risk of melanomas harboring BRAF mutations. 18368129

2008
dbSNP: rs121913348
rs121913348
BRAF
A 0.700 CausalMutation CLINVAR Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines. 17314276

2007
dbSNP: rs397516896
rs397516896
BRAF
T 0.700 GeneticVariation CLINVAR B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis. 17311103

2007
dbSNP: rs397516896
rs397516896
BRAF
T 0.700 GeneticVariation CLINVAR Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer. 17096326

2007
dbSNP: rs397516896
rs397516896
BRAF
T 0.700 GeneticVariation CLINVAR NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: a study based on mutation screening by pyrosequencing. 17119447

2006
dbSNP: rs121913378
rs121913378
BRAF
A 0.700 GeneticVariation CLINVAR Inactivation of the mitogen-activated protein kinase pathway as a potential target-based therapy in ovarian serous tumors with KRAS or BRAF mutations. 15753399

2005
dbSNP: rs121913338
rs121913338
BRAF
C 0.700 CausalMutation CLINVAR Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas. 14688025

2004
dbSNP: rs121913353
rs121913353
BRAF
T 0.700 GeneticVariation CLINVAR Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis. 15046639

2004