|
rs113488022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As compared to the BRAF wild-type cohort (WT), the BRAF V600E cohort had a similar mean age at diagnosis [BRAF V600E: 7 years (3-12 y), vs. WT: 7.6 years (1-18 y)] but demonstrated a stronger male/female ratio (BRAF V600E: 4 vs WT: 0.67), and had both more multifocal CNS disease ( BRAFV600E: 80% vs WT: 20%) and systemic disease (BRAF V600E: 40% vs WT: none).
|
31685033 |
2019 |
|
rs121913377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As compared to the BRAF wild-type cohort (WT), the BRAF V600E cohort had a similar mean age at diagnosis [BRAF V600E: 7 years (3-12 y), vs. WT: 7.6 years (1-18 y)] but demonstrated a stronger male/female ratio (BRAF V600E: 4 vs WT: 0.67), and had both more multifocal CNS disease ( BRAFV600E: 80% vs WT: 20%) and systemic disease (BRAF V600E: 40% vs WT: none).
|
31685033 |
2019 |
|
rs17576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the frequency of the rs17576 G allele was significantly higher in TBE patients with severe CNS diseases such as meningo-encephalitis (43.5%) when compared with TBE patients with milder meningitis (26.3%; P = 0.01), as well as with the population control group (32.5%; P = 0.042).
|
29496490 |
2018 |
|
rs6265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Val66Met (G196A; rs6265) single nucleotide polymorphism of brain-derived neurotrophic factor (BDNF) affects morphology and neuronal activity, and is expected to be associated with central nervous system disorders.
|
25523127 |
2015 |
|
rs746682028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Val66Met (G196A; rs6265) single nucleotide polymorphism of brain-derived neurotrophic factor (BDNF) affects morphology and neuronal activity, and is expected to be associated with central nervous system disorders.
|
25523127 |
2015 |
|
rs759834365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Val66Met (G196A; rs6265) single nucleotide polymorphism of brain-derived neurotrophic factor (BDNF) affects morphology and neuronal activity, and is expected to be associated with central nervous system disorders.
|
25523127 |
2015 |
|
rs1732778
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant differences in genotype, allele, and haplotype frequencies for 3 OAS2 single nucleotide polymorphisms (rs1293762, rs15895, and rs1732778) and 2 OAS3 single nucleotide polymorphisms (rs2285932 and rs2072136) were detected between patients with central nervous system disease and both those with fever and/or meningitis and the control group.
|
21050126 |
2010 |
|
rs2072136
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant differences in genotype, allele, and haplotype frequencies for 3 OAS2 single nucleotide polymorphisms (rs1293762, rs15895, and rs1732778) and 2 OAS3 single nucleotide polymorphisms (rs2285932 and rs2072136) were detected between patients with central nervous system disease and both those with fever and/or meningitis and the control group.
|
21050126 |
2010 |
|
rs121918075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with familial amyloidotic polyneuropathy amyloidogenic transthyretin Y114C had CNS disorders related to amyloid deposition in leptomeninges, vessel walls, and parenchyma in spinal cord and the brain.
|
16217058 |
2005 |
|
rs946880677
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with familial amyloidotic polyneuropathy amyloidogenic transthyretin Y114C had CNS disorders related to amyloid deposition in leptomeninges, vessel walls, and parenchyma in spinal cord and the brain.
|
16217058 |
2005 |
|
rs121918098
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CNS disease may result owing to the sensitivity of the CNS to lower levels of D18G aggregate.
|
12779320 |
2003 |