Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2235371
rs2235371
IRF6
0.730 GeneticVariation BEFREE The genotype and allele frequencies of single nucleotide polymorphism rs2235371 in IRF6 showed significant differences in patients with cleft palate when compared to the controls, whereas no association was shown between rs642961, rs2236907, rs861019, and rs1044516 and non-syndromic orofacial clefts. 31495697

2019
dbSNP: rs41268753
rs41268753
GRHL3
0.730 GeneticVariation BEFREE Moreover, it is known that this SNP, as well as another variant, rs41268753 (p.T454M), are associated with nonsyndromic cleft palate and that rs41268753 negatively affects GRHL3 transcriptional activity. 29702134

2018
dbSNP: rs41268753
rs41268753
GRHL3
0.730 GeneticVariation GWASCAT Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate. 28054174

2017
dbSNP: rs41268753
rs41268753
GRHL3
0.730 GeneticVariation BEFREE In both the discovery and replication samples, rs41268753 conferred increased risk for CP (OR = 8.3, 95% CI 4.1-16.8; OR = 2.16, 95% CI 1.43-3.27, respectively). 27018472

2016
dbSNP: rs41268753
rs41268753
GRHL3
0.730 GeneticVariation BEFREE The variant rs41268753 in GRHL3 increases the risk for cleft palate in European population, but our findings failed to detect the link between two GRHL3 SNPs (rs2486668 and rs545809) and risk to NSOFC in the Han Chinese cohort. 27459192

2016
dbSNP: rs41268753
rs41268753
GRHL3
T 0.730 GeneticVariation GWASCAT In both the discovery and replication samples, rs41268753 conferred increased risk for CP (OR = 8.3, 95% CI 4.1-16.8; OR = 2.16, 95% CI 1.43-3.27, respectively). 27018472

2016
dbSNP: rs2235371
rs2235371
IRF6
C 0.730 GeneticVariation GWASCAT Genome-wide association study identifies a new susceptibility locus for cleft lip with or without a cleft palate. 25775280

2015
dbSNP: rs2235371
rs2235371
IRF6
0.730 GeneticVariation BEFREE In the single locus analyses, we found rs642961 AG and AG/AA genotypes were associated with increased risk of NSOC, especially cleft lip with or without cleft palate (CL/P) and cleft lip with cleft palate (CLP), while significantly decreased risks were associated with rs2235371 CT and CT/TT genotypes. 20799332

2010
dbSNP: rs2235371
rs2235371
IRF6
0.730 GeneticVariation BEFREE Association analysis between the IRF6 G820A polymorphism and nonsyndromic cleft lip and/or cleft palate in a Chinese population. 19115793

2009
dbSNP: rs13041247
rs13041247
LOC102724968
T 0.710 GeneticVariation GWASCAT Genome-wide association study identifies a new susceptibility locus for cleft lip with or without a cleft palate. 25775280

2015
dbSNP: rs13041247
rs13041247
LOC102724968
0.710 GeneticVariation BEFREE SNPs near two genes not previously associated with cleft lip with and without cleft palate (MAFB, most significant SNP rs13041247, with odds ratio (OR) per minor allele = 0.704, 95% CI 0.635-0.778, P = 1.44 x 10(-11); and ABCA4, most significant SNP rs560426, with OR = 1.432, 95% CI 1.292-1.587, P = 5.01 x 10(-12)) and two previously identified regions (at chromosome 8q24 and IRF6) attained genome-wide significance. 20436469

2010
dbSNP: rs10242177
rs10242177 		0.700 GeneticVariation GWASCAT Genomic analyses in African populations identify novel risk loci for cleft palate. 30452639

2019
dbSNP: rs113691307
rs113691307
LOC102724542
C 0.700 GeneticVariation GWASCAT Genomic analyses in African populations identify novel risk loci for cleft palate. 30452639

2019
dbSNP: rs11597348
rs11597348
OPALIN
0.700 GeneticVariation GWASCAT Genomic analyses in African populations identify novel risk loci for cleft palate. 30452639

2019
dbSNP: rs143238378
rs143238378
LINC02476
G 0.700 GeneticVariation GWASCAT Genomic analyses in African populations identify novel risk loci for cleft palate. 30452639

2019
dbSNP: rs150382487
rs150382487
LINC02476
T 0.700 GeneticVariation GWASCAT Genomic analyses in African populations identify novel risk loci for cleft palate. 30452639

2019
dbSNP: rs1528845
rs1528845 		0.700 GeneticVariation GWASCAT Genomic analyses in African populations identify novel risk loci for cleft palate. 30452639

2019
dbSNP: rs182830500
rs182830500
LINC02476
T 0.700 GeneticVariation GWASCAT Genomic analyses in African populations identify novel risk loci for cleft palate. 30452639

2019
dbSNP: rs188681640
rs188681640
LINC02476
0.700 GeneticVariation GWASCAT Genomic analyses in African populations identify novel risk loci for cleft palate. 30452639

2019
dbSNP: rs189675673
rs189675673
SULT2A1
G 0.700 GeneticVariation GWASCAT Genomic analyses in African populations identify novel risk loci for cleft palate. 30452639

2019
dbSNP: rs2325377
rs2325377 		0.700 GeneticVariation GWASCAT Genomic analyses in African populations identify novel risk loci for cleft palate. 30452639

2019
dbSNP: rs2405373
rs2405373
LOC105376157
0.700 GeneticVariation GWASCAT Genomic analyses in African populations identify novel risk loci for cleft palate. 30452639

2019
dbSNP: rs28434654
rs28434654
LOC105376157
0.700 GeneticVariation GWASCAT Genomic analyses in African populations identify novel risk loci for cleft palate. 30452639

2019
dbSNP: rs28637199
rs28637199
LOC105376157
0.700 GeneticVariation GWASCAT Genomic analyses in African populations identify novel risk loci for cleft palate. 30452639

2019
dbSNP: rs28689133
rs28689133
LOC105376157
0.700 GeneticVariation GWASCAT Genomic analyses in African populations identify novel risk loci for cleft palate. 30452639

2019