|
rs2230288
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Also, we replicated previous reports of GBA coding variants (rs2230288: p.E365K; rs75548401: p.T408M) being associated with greater motor and cognitive decline over time, and an APOE E4 tagging variant (rs429358) being associated with greater cognitive deficits in patients.
|
31505070 |
2019 |
|
rs2230288
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Also, we replicated previous reports of GBA coding variants (rs2230288: p.E365K; rs75548401: p.T408M) being associated with greater motor and cognitive decline over time, and an APOE E4 tagging variant (rs429358) being associated with greater cognitive deficits in patients.
|
31505070 |
2019 |
|
rs2230288
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The discovery that E326K negatively impacts cognitive performance approximately doubles the proportion of PD patients we now recognize are at risk for more severe GBA-related cognitive deficits.
|
26296077 |
2016 |
|
rs34637584
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The objective of this study was to determine whether human LRRK2 with G2019S mutation causes hippocampus-dependent cognitive deficits in mice.
|
28487191 |
2017 |
|
rs34637584
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Contrastingly, high levels of human LRRK2 cause locomotor alterations and cognitive deficits accompanied by reduced striatal dopamine levels, with the latter also observed in G2019S mutant mice.
|
26282470 |
2015 |
|
rs371425292
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we examined the effect of obovatol on cognitive deficits in two separate AD models: (i) mice that received intracerebroventricular (i.c.v.) infusion of Aβ(1-42) (2.0 μg/mouse) and (ii) Tg2576 mice-expressing mutant human amyloid precursor protein (K670N, M671L).
|
22212065 |
2012 |
|
rs371425292
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Both synaptic and cognitive deficits are reproduced in mice double transgenic for amyloid precursor protein (AA substitution K670N,M671L) and presenilin-1 (AA substitution M146V).
|
15578094 |
2004 |
|
rs572842823
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Both synaptic and cognitive deficits are reproduced in mice double transgenic for amyloid precursor protein (AA substitution K670N,M671L) and presenilin-1 (AA substitution M146V).
|
15578094 |
2004 |
|
rs572842823
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we examined the effect of obovatol on cognitive deficits in two separate AD models: (i) mice that received intracerebroventricular (i.c.v.) infusion of Aβ(1-42) (2.0 μg/mouse) and (ii) Tg2576 mice-expressing mutant human amyloid precursor protein (K670N, M671L).
|
22212065 |
2012 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<i>BDNF</i> gene Val66Met variation may be associated with cognitive deficits in T2DM, especially with delayed memory.
|
29423073 |
2018 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression.
|
26000753 |
2015 |
|
rs759834365
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<i>BDNF</i> gene Val66Met variation may be associated with cognitive deficits in T2DM, especially with delayed memory.
|
29423073 |
2018 |
|
rs759834365
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression.
|
26000753 |
2015 |
|
rs1018381
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variation in dysbindin 1 (DTNBP1) gene region tagged by SNP rs1018381 exhibits a linkage with cognitive deficits in patients with schizophrenia and healthy subjects.
|
19497374 |
2009 |
|
rs104893877
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we first provided evidence that RV treatment alleviated motor and cognitive deficits in the A53T α-synuclein mouse model of PD in a dose-dependent manner.
|
30462117 |
2018 |
|
rs104893878
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TCE or TaClo did not appear to lead to acceleration of motor or cognitive deficits in either wild type or A30P mutant mice, potentially because of the modest reductions of DA neuronal number in the SNpc.
|
31422098 |
2019 |
|
rs1051266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We hypothesized that ADHD related cognitive deficit could be attributed to abnormalities in the folate cycle and explored functional single nucleotide polymorphisms in methylenetetrahydrofolate dehydrogenase (rs2236225), reduced folate carrier (rs1051266), and methylenetetrahydrofolate reductase (rs1801131 and rs1801133) in families with ADHD probands (N = 185) and ethnically matched controls (N = 216) recruited following the DSM-IV.
|
25079255 |
2014 |
|
rs10748842
|
|
|
0.010 |
GeneticVariation |
BEFREE |
NRG3 rs10748842 may not confer susceptibility to schizophrenia, but may be more closely associated with cognitive deficit, especially attention performance in chronic schizophrenia.
|
31753594 |
2020 |
|
rs1108580
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study examines the association of plasma DβH (pDβH) activity, DBH gene polymorphisms (-1021C>T, rs1611115 and 444G>A, rs1108580) and cognitive deficits in Han Chinese patients with schizophrenia.
|
28647493 |
2018 |
|
rs11136000
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs11136000 genotypes in combination with HDL levels and knowledge about diabetes background may be used as a predictive medicine tool for cognitive disorders.
|
30560405 |
2019 |
|
rs121909668
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats.
|
30273830 |
2018 |
|
rs1223904774
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both synaptic and cognitive deficits are reproduced in mice double transgenic for amyloid precursor protein (AA substitution K670N,M671L) and presenilin-1 (AA substitution M146V).
|
15578094 |
2004 |
|
rs1245342105
|
|
|
0.010 |
GeneticVariation |
BEFREE |
3xTg mice, which express an APP/PS1 mutation combined with a tau (P301L) mutation and that develop cognitive deficits at 6 months of age, were subjected to ELF-MF (50Hz, 500μT) exposure or sham exposure daily for 3 months.
|
26945731 |
2016 |
|
rs1315695444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that minor alleles of the CRP 1059G/C SNP (odds ratio [OR] 0.37, 95% confidence interval [CI] 0.16 to 0.78; p = 0.013) and the SELP 1087G/A SNP (OR 0.51, 95% CI 0.30 to 0.85; p = 0.011) were associated with a reduction in cognitive deficit in European Americans (n = 443).
|
17498578 |
2007 |
|
rs1329650
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C* allele of rs1329650 may be increasing the risk for ADHD and smoking behaviour through a common mechanism, possibly externalising behaviours and specific cognitive deficits that manifest as ADHD in childhood and are the gateway to smoking behaviour later in life.
|
23109089 |
2012 |