|
rs2344484
|
|
|
0.010 |
GeneticVariation |
BEFREE |
C-allele-carrier patients and healthy volunteers had smaller total cerebral GM and temporal GM volumes than their respective T-homozygous counterparts. rs2344484-C-allele was further associated with generalized cognitive deficits among schizophrenia patients but not in healthy volunteers.
|
18799289 |
2008 |
|
rs761715536
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, we replicated previous reports of GBA coding variants (rs2230288: p.E365K; rs75548401: p.T408M) being associated with greater motor and cognitive decline over time, and an APOE E4 tagging variant (rs429358) being associated with greater cognitive deficits in patients.
|
31505070 |
2019 |
|
rs429358
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, we replicated previous reports of GBA coding variants (rs2230288: p.E365K; rs75548401: p.T408M) being associated with greater motor and cognitive decline over time, and an APOE E4 tagging variant (rs429358) being associated with greater cognitive deficits in patients.
|
31505070 |
2019 |
|
rs371425292
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we examined the effect of obovatol on cognitive deficits in two separate AD models: (i) mice that received intracerebroventricular (i.c.v.) infusion of Aβ(1-42) (2.0 μg/mouse) and (ii) Tg2576 mice-expressing mutant human amyloid precursor protein (K670N, M671L).
|
22212065 |
2012 |
|
rs371425292
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Both synaptic and cognitive deficits are reproduced in mice double transgenic for amyloid precursor protein (AA substitution K670N,M671L) and presenilin-1 (AA substitution M146V).
|
15578094 |
2004 |
|
rs572842823
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Both synaptic and cognitive deficits are reproduced in mice double transgenic for amyloid precursor protein (AA substitution K670N,M671L) and presenilin-1 (AA substitution M146V).
|
15578094 |
2004 |
|
rs572842823
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we examined the effect of obovatol on cognitive deficits in two separate AD models: (i) mice that received intracerebroventricular (i.c.v.) infusion of Aβ(1-42) (2.0 μg/mouse) and (ii) Tg2576 mice-expressing mutant human amyloid precursor protein (K670N, M671L).
|
22212065 |
2012 |
|
rs1223904774
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both synaptic and cognitive deficits are reproduced in mice double transgenic for amyloid precursor protein (AA substitution K670N,M671L) and presenilin-1 (AA substitution M146V).
|
15578094 |
2004 |
|
rs1386984902
|
|
|
0.010 |
GeneticVariation |
BEFREE |
3xTg mice, which express an APP/PS1 mutation combined with a tau (P301L) mutation and that develop cognitive deficits at 6 months of age, were subjected to ELF-MF (50Hz, 500μT) exposure or sham exposure daily for 3 months.
|
26945731 |
2016 |
|
rs1800557
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We recently reported an alanine to valine mutation in codon 713 in a single case of chronic familial schizophrenia with cognitive deficits.
|
8049900 |
1994 |
|
rs80356537
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The α3(+/D801Y) mice displayed hyperactivity, increased sensitivity to chemically induced epileptic seizures and cognitive deficits.
|
27549929 |
2016 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<i>BDNF</i> gene Val66Met variation may be associated with cognitive deficits in T2DM, especially with delayed memory.
|
29423073 |
2018 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression.
|
26000753 |
2015 |
|
rs759834365
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<i>BDNF</i> gene Val66Met variation may be associated with cognitive deficits in T2DM, especially with delayed memory.
|
29423073 |
2018 |
|
rs759834365
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression.
|
26000753 |
2015 |
|
rs16969968
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results show that rs16969968 on CHRNA5 is tightly linked to genetic susceptibility, psychotic symptoms and cognitive deficits in SCZ in an early-onset Chinese population, suggesting that CHRNA5 may play an important role in the etiology of SCZ.
|
30366711 |
2019 |
|
rs11136000
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs11136000 genotypes in combination with HDL levels and knowledge about diabetes background may be used as a predictive medicine tool for cognitive disorders.
|
30560405 |
2019 |
|
rs4673
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, 8-hydroxydeoxyguanine urine levels and NOX activity were lower among children without cognitive deficits and particularly among those with the rs4673 polymorphism.
|
21902598 |
2012 |
|
rs1108580
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study examines the association of plasma DβH (pDβH) activity, DBH gene polymorphisms (-1021C>T, rs1611115 and 444G>A, rs1108580) and cognitive deficits in Han Chinese patients with schizophrenia.
|
28647493 |
2018 |
|
rs1611115
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study examines the association of plasma DβH (pDβH) activity, DBH gene polymorphisms (-1021C>T, rs1611115 and 444G>A, rs1108580) and cognitive deficits in Han Chinese patients with schizophrenia.
|
28647493 |
2018 |
|
rs7157599
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A genome-wide association study of cognitive deficits in patients with schizophrenia in Japan found association with a missense genetic variant (rs7157599, Asn8Ser) in the delta(4)-desaturase, sphingolipid 2 (DEGS2) gene.
|
25871975 |
2015 |
|
rs1018381
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variation in dysbindin 1 (DTNBP1) gene region tagged by SNP rs1018381 exhibits a linkage with cognitive deficits in patients with schizophrenia and healthy subjects.
|
19497374 |
2009 |
|
rs121909668
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats.
|
30273830 |
2018 |
|
rs2230288
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Also, we replicated previous reports of GBA coding variants (rs2230288: p.E365K; rs75548401: p.T408M) being associated with greater motor and cognitive decline over time, and an APOE E4 tagging variant (rs429358) being associated with greater cognitive deficits in patients.
|
31505070 |
2019 |
|
rs2230288
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Also, we replicated previous reports of GBA coding variants (rs2230288: p.E365K; rs75548401: p.T408M) being associated with greater motor and cognitive decline over time, and an APOE E4 tagging variant (rs429358) being associated with greater cognitive deficits in patients.
|
31505070 |
2019 |