|
rs56053615
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This result raises the possibility that OGG1 R154H may function as a low/moderate-penetrance modifier for colorectal cancer development.
|
15449173 |
2004 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Carriers of the variant allele OGG1 Ser326Cys polymorphism had a lowered risk of colorectal cancer, OR=0.56 (95% confidence interval 0.33-0.95), while no association were found with risk of adenomas.
|
15946795 |
2005 |
|
rs1245554802
|
|
|
0.020 |
GeneticVariation |
BEFREE |
GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer.
|
15946795 |
2005 |
|
rs771306418
|
|
|
0.020 |
GeneticVariation |
BEFREE |
GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer.
|
15946795 |
2005 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphism OGG1 S326C was associated with an increased risk of colorectal cancer [odds ratio (OR), 2.3; 95% confidence interval (95% CI), 1.1-5.0], the risk being higher in younger individuals.
|
16609022 |
2006 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that unlike for other cancer types, the hOGG1 Ser326Cys polymorphism is not a major genetic risk factor for colorectal cancer.
|
17827862 |
2007 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The analysis of binary genotype combinations showed increased co</span>lorectal cancer risk in individuals simultaneously homozygous for the variant alleles of APE1 Asn148Glu and hOGG1 Ser326Cys (OR: 6.37; 95% CI: 1.40-29.02; p=0.02).
|
17991492 |
2008 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, the distributions of OGG1 Ser326Cys and XRCC1 Arg399Gln were not associated with a colorectal cancer risk.
|
18823566 |
2008 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
GPX1 Pro(198)Leu, hOGG1 Ser(326)Cys and erythrocyte GPX enzyme activity were not associated with risk of colorectal cancer.
|
19428376 |
2009 |
|
rs1245554802
|
|
|
0.020 |
GeneticVariation |
BEFREE |
GPX1 Pro(198)Leu, hOGG1 Ser(326)Cys and erythrocyte GPX enzyme activity were not associated with risk of colorectal cancer.
|
19428376 |
2009 |
|
rs771306418
|
|
|
0.020 |
GeneticVariation |
BEFREE |
GPX1 Pro(198)Leu, hOGG1 Ser(326)Cys and erythrocyte GPX enzyme activity were not associated with risk of colorectal cancer.
|
19428376 |
2009 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, the Lys751Gln polymorphism of the XPD gene and the Ser326Cys polymorphism of the hOGG1 gene are not associated with colorectal cancer in a Polish population.
|
19561388 |
2009 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association of OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms and the susceptibility to colorectal carcinoma with or without oxidative stress were evaluated.
|
20649433 |
2010 |
|
rs746702110
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Using a family-based study, we investigated the role of polymorphisms in 4 BER genes (APEX1 Gln51His, Asp148Glu; OGG1 Ser236Cys; PARP Val742Ala; and XRCC1 Arg194Trp, Arg280His, Arg399Gln) as potential CRC risk factors and modifiers of the association between diets high in red meat or poultry and CRC risk.
|
21037106 |
2010 |
|
rs1419684880
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using a family-based study, we investigated the role of polymorphisms in 4 BER genes (APEX1 Gln51His, Asp148Glu; OGG1 Ser236Cys; PARP Val742Ala; and XRCC1 Arg194Trp, Arg280His, Arg399Gln) as potential CRC risk factors and modifiers of the association between diets high in red meat or poultry and CRC risk.
|
21037106 |
2010 |
|
rs756363791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe here the first pathogenic germline mutation in OGG1, a splice site mutation affecting exon 1, which was inherited from the father, in combination with a maternal MUTYH missense mutation p.Ile223Val in a female patient with advanced synchronous colon cancer and adenomas at the age of 36 years pointing towards digenic inheritance for colorectal cancer (CRC) predisposition.
|
21195604 |
2011 |
|
rs104893751
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two rare variants (OGG1 c.137G>A; MUTYH c.1187G>A) and one common polymorphism (NUDT1 c.426C>T) were associated with CRC risk.
|
21355073 |
2011 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
APE1 Asp148Glu and hOGG1 Ser326Cys polymorphisms might be associated with increasing risk of CRC in a Turkish population.
|
21561390 |
2011 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests that the OGG1 Ser326Cys polymorphism is not associated with CRC risk.
|
21695387 |
2011 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no significant association between OGG1 Ser326Cys polymorphism and CRC, but the homozygous Cys/Cys variant genotype was associated with an increased risk of colon cancer (p<0.05).
|
21899442 |
2012 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that there is no robust association between hOGG1 Ser326Cys polymorphism and colorectal cancer.
|
22526153 |
2012 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The 326Ser/Cys OGG1 and the 324Gln/His as well as the 324His/His MUTYH genotypes were found to be associated with an increased CRC risk, while no association was found for the XRCC1 gene polymorphisms.
|
23618615 |
2013 |
|
rs746702110
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this work, we evaluated associations between the repair efficiency of oxidative DNA lesions and single-nucleotide polymorphisms of BER genes: the 194Trp/Arg and the 399Arg/Gln XRCC1, the 326Ser/Cys OGG1 and the 324Gln/His MUTYH and CRC occurrence in a Polish population.
|
23618615 |
2013 |
|
rs113561019
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A rare inherited nonsynonymous variant in OGG1 (Gly308Glu), the functional partner of MUTYH, was over-represented in case patients with advanced CRC compared with population-based control subjects (n = 36 of 2142 case patients vs n = 15 of 2175 control subjects in the training phase, P = 1.8×10(-3); and n = 22 of 1005 case patients vs n = 8 of 1389 control subjects in the validation phase, P = 4.8×10(-4); P = 1.4×10(-5) combined; odds ratio = 2.92, 95% confidence interval = 1.80 to 4.74).
|
23852950 |
2013 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analysis of all 13 studies showed that OGG1 rs1052133 polymorphism was significantly associated with the risk of colo</span>rectal cancer in Caucasian population (Cys versus Ser OR = 1.20, 95% CI = 1.03-1.39, P = 0.02; CysCys versus SerSer OR = 1.44, 95% CI = 1.04-2.00, P = 0.03; CysCys versus SerSer/SerCys OR = 1.39, 95% CI = 1.15-1.67, P = 0.0005).
|
23975367 |
2014 |