rs1400826115
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that XPD G751A, hOGG1 C326G and XRCC4 G1394T gene polymorphisms might play an important role in colorectal carcinogenesis and increase the risk of developing CRC in the Chinese Han population.
|
30429230 |
2019 |
rs113561019
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A rare inherited nonsynonymous variant in OGG1 (Gly308Glu), the functional partner of MUTYH, was over-represented in case patients with advanced CRC compared with population-based control subjects (n = 36 of 2142 case patients vs n = 15 of 2175 control subjects in the training phase, P = 1.8×10(-3); and n = 22 of 1005 case patients vs n = 8 of 1389 control subjects in the validation phase, P = 4.8×10(-4); P = 1.4×10(-5) combined; odds ratio = 2.92, 95% confidence interval = 1.80 to 4.74).
|
23852950 |
2013 |
rs104893751
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two rare variants (OGG1 c.137G>A; MUTYH c.1187G>A) and one common polymorphism (NUDT1 c.426C>T) were associated with CRC risk.
|
21355073 |
2011 |
rs756363791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe here the first pathogenic germline mutation in OGG1, a splice site mutation affecting exon 1, which was inherited from the father, in combination with a maternal MUTYH missense mutation p.Ile223Val in a female patient with advanced synchronous colon cancer and adenomas at the age of 36 years pointing towards digenic inheritance for colorectal cancer (CRC) predisposition.
|
21195604 |
2011 |
rs1419684880
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using a family-based study, we investigated the role of polymorphisms in 4 BER genes (APEX1 Gln51His, Asp148Glu; OGG1 Ser236Cys; PARP Val742Ala; and XRCC1 Arg194Trp, Arg280His, Arg399Gln) as potential CRC risk factors and modifiers of the association between diets high in red meat or poultry and CRC risk.
|
21037106 |
2010 |
rs56053615
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To evaluate the effects of OGG1 (Ser326Cys, 11657A/G, and Arg154His) and APE1 (Asp148Glu, and T-656G) polymorphisms on colorectal cancer (CRC) risk.
|
27022219 |
2016 |
rs746702110
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this work, we evaluated associations between the repair efficiency of oxidative DNA lesions and single-nucleotide polymorphisms of BER genes: the 194Trp/Arg and the 399Arg/Gln XRCC1, the 326Ser/Cys OGG1 and the 324Gln/His MUTYH and CRC occurrence in a Polish population.
|
23618615 |
2013 |
rs746702110
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Using a family-based study, we investigated the role of polymorphisms in 4 BER genes (APEX1 Gln51His, Asp148Glu; OGG1 Ser236Cys; PARP Val742Ala; and XRCC1 Arg194Trp, Arg280His, Arg399Gln) as potential CRC risk factors and modifiers of the association between diets high in red meat or poultry and CRC risk.
|
21037106 |
2010 |
rs1245554802
|
|
|
0.020 |
GeneticVariation |
BEFREE |
GPX1 Pro(198)Leu, hOGG1 Ser(326)Cys and erythrocyte GPX enzyme activity were not associated with risk of colorectal cancer.
|
19428376 |
2009 |
rs771306418
|
|
|
0.020 |
GeneticVariation |
BEFREE |
GPX1 Pro(198)Leu, hOGG1 Ser(326)Cys and erythrocyte GPX enzyme activity were not associated with risk of colorectal cancer.
|
19428376 |
2009 |
rs1245554802
|
|
|
0.020 |
GeneticVariation |
BEFREE |
GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer.
|
15946795 |
2005 |
rs771306418
|
|
|
0.020 |
GeneticVariation |
BEFREE |
GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer.
|
15946795 |
2005 |
rs56053615
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This result raises the possibility that OGG1 R154H may function as a low/moderate-penetrance modifier for colorectal cancer development.
|
15449173 |
2004 |
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This research aimed to study the associations between XPD (G751A, rs13181), hOGG1 (C326G, rs1052133) and XRCC4 (G1394T, rs6869366) gene polymorphisms and the risk of colorectal cancer (CRC) in a Chinese Han population.
|
30429230 |
2019 |
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The CRC risk was higher in patients with the OGG1 326Ser/Cys + Cys/Cys genotype (OR = 1.38, 95%CI: 1.03-1.85, P = 0.030), particularly high in patients with stage III + IV cancer (OR = 1.48, 95%CI: 1.03-2.13) compared with patients with the Ser/Ser genotype.
|
27022219 |
2016 |
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In subgroup analyses by cancer types, we found that the hOGG1 Ser326Cys polymorphism may increase hepatocellular cancer and colorectal cancer risks, but decrease the risk of oral cancer.
|
25323581 |
2015 |
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analysis of all 13 studies showed that OGG1 rs1052133 polymorphism was significantly associated with the risk of colo</span>rectal cancer in Caucasian population (Cys versus Ser OR = 1.20, 95% CI = 1.03-1.39, P = 0.02; CysCys versus SerSer OR = 1.44, 95% CI = 1.04-2.00, P = 0.03; CysCys versus SerSer/SerCys OR = 1.39, 95% CI = 1.15-1.67, P = 0.0005).
|
23975367 |
2014 |
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The overall data indicated a significant association of hOGG1 Ser326</span>Cys polymorphism on colorectal cancer risk (allele model OR = 1.14, 95 %CI 1.02-1.27; homozygote model OR = 1.32, 95 %CI 0.92-1.92; recessive model OR = 1.12, 95 %CI 1.00-1.26; dominant model OR = 1.15, 95 %CI 1.00-1.32).
|
25227662 |
2014 |
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The 326Ser/Cys OGG1 and the 324Gln/His as well as the 324His/His MUTYH genotypes were found to be associated with an increased CRC risk, while no association was found for the XRCC1 gene polymorphisms.
|
23618615 |
2013 |
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that there is no robust association between hOGG1 Ser326Cys polymorphism and colorectal cancer.
|
22526153 |
2012 |
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no significant association between OGG1 Ser326Cys polymorphism and CRC, but the homozygous Cys/Cys variant genotype was associated with an increased risk of colon cancer (p<0.05).
|
21899442 |
2012 |
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests that the OGG1 Ser326Cys polymorphism is not associated with CRC risk.
|
21695387 |
2011 |
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
APE1 Asp148Glu and hOGG1 Ser326Cys polymorphisms might be associated with increasing risk of CRC in a Turkish population.
|
21561390 |
2011 |
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association of OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms and the susceptibility to colorectal carcinoma with or without oxidative stress were evaluated.
|
20649433 |
2010 |
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, the Lys751Gln polymorphism of the XPD gene and the Ser326Cys polymorphism of the hOGG1 gene are not associated with colorectal cancer in a Polish population.
|
19561388 |
2009 |