Gene: AXIN2 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121908567
rs121908567
AXIN2
A 0.700 CausalMutation CLINVAR

dbSNP: rs1567755946
rs1567755946
AXIN2
GGCCGCGGGAGGCA 0.700 CausalMutation CLINVAR

dbSNP: rs267606674
rs267606674
AXIN2
G 0.700 CausalMutation CLINVAR

dbSNP: rs2240308
rs2240308
AXIN2
0.030 GeneticVariation BEFREE The aim of this study was to investigate the association of the rs2240308 and rs1133683 polymorphisms in the AXIN2 gene with colorectal cancer (CRC) in Mexican patients. 27228364

2016
dbSNP: rs2240308
rs2240308
AXIN2
0.030 GeneticVariation BEFREE To assess the contribution of Axin2 SNP to CRC susceptibility, we examined the Axin2 C148T genotype in CRC patients and 170 healthy controls by PCR-RFLP. 22207181

2012
dbSNP: rs2240308
rs2240308
AXIN2
0.030 GeneticVariation BEFREE These results suggest that the AXIN2 Pro50Ser SNP is associated with development of lung cancer as a protective SNP, while an association between the AXIN2 SNP and risk of colorectal cancer and of head and neck cancer was not observed. 16820935

2006
dbSNP: rs3923087
rs3923087
AXIN2
0.010 GeneticVariation BEFREE We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110). 31485167

2019
dbSNP: rs4791171
rs4791171
AXIN2
0.010 GeneticVariation BEFREE We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110). 31485167

2019
dbSNP: rs1133683
rs1133683
AXIN2
0.010 GeneticVariation BEFREE The aim of this study was to investigate the association of the rs2240308 and rs1133683 polymorphisms in the AXIN2 gene with colorectal cancer (CRC) in Mexican patients. 27228364

2016
dbSNP: rs121908568
rs121908568
AXIN2
0.010 GeneticVariation BEFREE We analysed this novel AXIN2 mutant, together with two reported AXIN2 mutants [c.1966C>T (p.Arg656Stop) and c.1994delG (p.Leu688Stop)] that cause colorectal cancer with and without oligodontia, to study the effect of the mutant p.His660Tyr on the Wnt/β-catenin signaling pathway and to compare the molecular pathogenesis of different AXIN2 mutants in tooth agenesis and carcinogenesis. 27090353

2016
dbSNP: rs730882193
rs730882193
AXIN2
0.010 GeneticVariation BEFREE Our data suggest the AXIN2 1989G>A mutation may not have solely a loss-of-function role in CRC. 26025668

2015