rs1883025
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
rs2515629
|
|
A |
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
rs3890182
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
rs3905000
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
rs4149268
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study suggests that three SNPs rs2230806, rs4149313, and rs9282541 in ABCA1 gene are significantly associated with susceptibility to CHD; further mechanism should be performed to be applied to drug research and development.
|
31006134 |
2019 |
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CONCLUSIONS This meta-analysis provides convincing evidence that polymorphism of ABCA1 R219K</span> is associated with susceptibility to CHD while the CRP +1059G/C polymorphism appears to have no correlation with susceptibility to CHD.
|
27560308 |
2016 |
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ABCA1 R219K polymorphism is associated with CHD susceptibility, and individuals with ABCA1 have a significantly higher risk of cancer particularly in Asians.
|
25104170 |
2015 |
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our results indicate that the ABCA1 R219K polymorphism is a protective factor of CHD in Asians, but not in Caucasians.
|
21643759 |
2012 |
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ATP-binding cassette transporter A1 R219K polymorphism and coronary artery disease in Chinese population: a meta-analysis of 5,388 participants.
|
23053993 |
2012 |
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis suggests that K allele of ABCA1 R219K polymorphism is a protective factor associated with decreased CHD susceptibility, but these associations vary in different ethnic populations.
|
21300560 |
2011 |
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations of the ATP-binding cassette transporter A1 R219K polymorphism with HDL-C level and coronary artery disease risk: a meta-analysis.
|
21310416 |
2011 |
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate for the first time the possible association between R219K gene polymorphism and coronary artery disease in an Iranian adult population.
|
20303467 |
2010 |
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the R219K polymorphism of ABCA1 was associated with altered lipoprotein levels and the R219K variant significantly modulated the HDL-C response to pravastatin in Chinese patients with CHD.
|
19673941 |
2009 |
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data confirm earlier observations that ABCA1 R219K and V771M polymorphisms may be associated with a protective role against CHD and extend those to another important pathologic condition, namely stroke.
|
16446539 |
2006 |
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, we provide additional evidence that the R219K polymorphism in the ABCA1 gene either directly or as a result of linkage disequilibrium with additional functional variant(s), has a protective effect against CHD and is associated with lower plasma triglycerides in sub-groups of patients with hyperlipidaemia.
|
12700893 |
2003 |
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The K allele of the R219K variant was significantly more frequent in FH subjects without premature CHD (0.32, 95% CI 0.27 to 0.37) than in FH subjects with premature CHD (0.25, 95% CI 0.21 to 0.29) (p<0.05), suggesting that the genetic variant R219K in ABCA1 could influence the development and progression of atherosclerosis in FH subjects.
|
12624133 |
2003 |
rs4149313
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study suggests that three SNPs rs2230806, rs4149313, and rs9282541 in ABCA1 gene are significantly associated with susceptibility to CHD; further mechanism should be performed to be applied to drug research and development.
|
31006134 |
2019 |
rs4149313
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The present meta-analysis suggests that the ABCA1 rs4149313 polymorphism may contribute to the risk of CHD, e</span>specially in Asian populations.
|
24942079 |
2014 |
rs4149313
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In silico replication supported the association of rs4149313 with coronary artery disease in an independent meta-analysis including 173,975 individuals of European descent from the CARDIoGRAMplusC4D consortium (odds ratio, 1.03; P-value, 0.048).
|
23555974 |
2013 |
rs146292819
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of rs146292819 Polymorphism in ABCA1 Gene with the Risk of Coronary Artery Disease in Pakistani Population.
|
30945099 |
2019 |
rs1800977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism rs1800977 was associated with susceptibility to CHD (AA vs GG, P = 0.013; A vs G, P = 0.029; recessive model, P = 0.020).
|
31006134 |
2019 |
rs9282541
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggests that three SNPs rs2230806, rs4149313, and rs9282541 in ABCA1 gene are significantly associated with susceptibility to CHD; further mechanism should be performed to be applied to drug research and development.
|
31006134 |
2019 |
rs2740483
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The interactions of rs1333040-rs1333042 on the risk of CHD and IS were relatively strong, whereas the interactions of rs1333040-rs1333042-rs2066715 and rs1333040-rs1333042-rs2066715-rs2740483 on the risk of CHD, and rs1333040-rs1333042-rs4977574 and rs1333040-rs1333042-rs4977574-rs2740483 on the risk of IS were relatively weak.
|
27096864 |
2016 |
rs1239681664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current meta-analysis suggests that ABCB1 C3435T polymorphism may contribute to the risk of CHD, especially for MI and ACS, among Caucasian populations.
|
24328528 |
2014 |