|
rs699947
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our overall and subgroup analyses suggested that rs699947 polymorphism was significantly associated with CHD susceptibility in both Caucasians and Asians, rs1570360 polymorphism was significantly associated with CHD susceptibility in Caucasians, and rs3025039 polymorphism was significantly associated with CHD susceptibility in Asians.
|
30317903 |
2018 |
|
rs699947
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In conclusion, our findings suggest that VEGFA rs699947 C>A, rs3025039 C>T and rs2010963 G>C polymorphisms are risk factors for CHD.
|
28430629 |
2017 |
|
rs699947
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Genetic polymorphisms on VEGF (rs699947) and KDR (rs2305948and rs1870377), as well as relevant haplotypes, may serve as genetic markers that might be useful in future investigations on the pathogenesis of CHD.
|
26726843 |
2016 |
|
rs699947
|
|
|
0.050 |
GeneticVariation |
BEFREE |
All of the combined effects of rs699947 (CC/CA) and rs2305948 (TT), rs3025039 (TT) and rs2305948 (TT), rs3025039 (CT) and rs1870377 (AA) had positive effects on the risk of CHD, respectively (all P < 0.05).
|
27175642 |
2016 |
|
rs699947
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We were unable to find strong association between analyzed polymorphisms in growth factors and the severity of coronary artery disease, although there was a trend toward association between rs699947 and the severity of CAD in patients without previous MI.
|
27835972 |
2016 |
|
rs3025039
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Further subgroup analyses according to ethnicity of study participants and type of disease demonstrated that the rs833061 polymorphism was significantly correlated with the risk of CHD in Asians under additive genetic model, and the rs3025039 polymorphism was significantly correlated with the risk of Tetralogy of Fallot (TOF) in dominant, recessive and allele models.
|
30689460 |
2018 |
|
rs3025039
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Overall, our findings indicate that VEGF rs699947, rs1570360, and rs3025039 polymorphisms may affect CHD susceptibility.
|
30317903 |
2018 |
|
rs3025039
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A significant association between VEGFA rs3025039 C>T polymorphism and risk of CHD was also found.
|
28430629 |
2017 |
|
rs3025039
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Genotype CT of rs3025039, TT of rs2305948, and AA of rs1873077 were associated with a reduced risk of CHD when smoking, alcohol intake and diabetes were considered, while homozygote GG of rs1570360 might elevate the susceptibility to CHD (all P < 0.05) for patients who were addicted to smoking or those with hypertension.
|
27175642 |
2016 |
|
rs1570360
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Overall, our findings indicate that VEGF rs699947, rs1570360, and rs3025039 polymorphisms may affect CHD susceptibility.
|
30317903 |
2018 |
|
rs1570360
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, our findings indicated that rs1570360 and rs833061 polymorphisms may affect the risk of CHD.
|
30689460 |
2018 |
|
rs2010963
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Besides, rs3025039 polymorphism was significantly correlated with the number of affected coronary arteries, while rs699947 and rs2010963 polymorphisms were significantly correlated with poor collateral circulation in CHD patients.
|
30317903 |
2018 |
|
rs2010963
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, our findings suggest that VEGFA rs699947 C>A, rs3025039 C>T and rs2010963 G>C polymorphisms are risk factors for CHD.
|
28430629 |
2017 |
|
rs1570360
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Genotype CT of rs3025039, TT of rs2305948, and AA of rs1873077 were associated with a reduced risk of CHD when smoking, alcohol intake and diabetes were considered, while homozygote GG of rs1570360 might elevate the susceptibility to CHD (all P < 0.05) for patients who were addicted to smoking or those with hypertension.
|
27175642 |
2016 |
|
rs2010963
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Angiotensin converting enzyme insertion/deletion (I/D) (rs4646994) and Vegf polymorphism (+405G/C; rs2010963) in type II diabetic patients: Association with the risk of coronary artery disease.
|
24505095 |
2015 |
|
rs833061
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further subgroup analyses according to ethnicity of study participants and type of disease demonstrated that the rs833061 polymorphism was significantly correlated with the risk of CHD in Asians under additive genetic model, and the rs3025039 polymorphism was significantly correlated with the risk of Tetralogy of Fallot (TOF) in dominant, recessive and allele models.
|
30689460 |
2018 |
|
rs1404013760
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, 187 unrelated Tibetan patients with CHD and 200 unrelated Tibetan healthy controls were screened for variants in the CITED2 gene; we subsequently identified one potential disease-causing mutation p.G143A in a 6-year-old girl with PDA and functional analyses of the mutation were carried out.
|
28687891 |
2017 |