|
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study suggests that three SNPs rs2230806, rs4149313, and rs9282541 in ABCA1 gene are significantly associated with susceptibility to CHD; further mechanism should be performed to be applied to drug research and development.
|
31006134 |
2019 |
|
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CONCLUSIONS This meta-analysis provides convincing evidence that polymorphism of ABCA1 R219K</span> is associated with susceptibility to CHD while the CRP +1059G/C polymorphism appears to have no correlation with susceptibility to CHD.
|
27560308 |
2016 |
|
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ABCA1 R219K polymorphism is associated with CHD susceptibility, and individuals with ABCA1 have a significantly higher risk of cancer particularly in Asians.
|
25104170 |
2015 |
|
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our results indicate that the ABCA1 R219K polymorphism is a protective factor of CHD in Asians, but not in Caucasians.
|
21643759 |
2012 |
|
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ATP-binding cassette transporter A1 R219K polymorphism and coronary artery disease in Chinese population: a meta-analysis of 5,388 participants.
|
23053993 |
2012 |
|
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis suggests that K allele of ABCA1 R219K polymorphism is a protective factor associated with decreased CHD susceptibility, but these associations vary in different ethnic populations.
|
21300560 |
2011 |
|
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations of the ATP-binding cassette transporter A1 R219K polymorphism with HDL-C level and coronary artery disease risk: a meta-analysis.
|
21310416 |
2011 |
|
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate for the first time the possible association between R219K gene polymorphism and coronary artery disease in an Iranian adult population.
|
20303467 |
2010 |
|
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the R219K polymorphism of ABCA1 was associated with altered lipoprotein levels and the R219K variant significantly modulated the HDL-C response to pravastatin in Chinese patients with CHD.
|
19673941 |
2009 |
|
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data confirm earlier observations that ABCA1 R219K and V771M polymorphisms may be associated with a protective role against CHD and extend those to another important pathologic condition, namely stroke.
|
16446539 |
2006 |
|
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, we provide additional evidence that the R219K polymorphism in the ABCA1 gene either directly or as a result of linkage disequilibrium with additional functional variant(s), has a protective effect against CHD and is associated with lower plasma triglycerides in sub-groups of patients with hyperlipidaemia.
|
12700893 |
2003 |
|
rs2230806
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The K allele of the R219K variant was significantly more frequent in FH subjects without premature CHD (0.32, 95% CI 0.27 to 0.37) than in FH subjects with premature CHD (0.25, 95% CI 0.21 to 0.29) (p<0.05), suggesting that the genetic variant R219K in ABCA1 could influence the development and progression of atherosclerosis in FH subjects.
|
12624133 |
2003 |
|
rs4149313
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study suggests that three SNPs rs2230806, rs4149313, and rs9282541 in ABCA1 gene are significantly associated with susceptibility to CHD; further mechanism should be performed to be applied to drug research and development.
|
31006134 |
2019 |
|
rs4149313
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The present meta-analysis suggests that the ABCA1 rs4149313 polymorphism may contribute to the risk of CHD, e</span>specially in Asian populations.
|
24942079 |
2014 |
|
rs4149313
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In silico replication supported the association of rs4149313 with coronary artery disease in an independent meta-analysis including 173,975 individuals of European descent from the CARDIoGRAMplusC4D consortium (odds ratio, 1.03; P-value, 0.048).
|
23555974 |
2013 |
|
rs146292819
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of rs146292819 Polymorphism in ABCA1 Gene with the Risk of Coronary Artery Disease in Pakistani Population.
|
30945099 |
2019 |
|
rs1800977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism rs1800977 was associated with susceptibility to CHD (AA vs GG, P = 0.013; A vs G, P = 0.029; recessive model, P = 0.020).
|
31006134 |
2019 |
|
rs9282541
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggests that three SNPs rs2230806, rs4149313, and rs9282541 in ABCA1 gene are significantly associated with susceptibility to CHD; further mechanism should be performed to be applied to drug research and development.
|
31006134 |
2019 |
|
rs2740483
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The interactions of rs1333040-rs1333042 on the risk of CHD and IS were relatively strong, whereas the interactions of rs1333040-rs1333042-rs2066715 and rs1333040-rs1333042-rs2066715-rs2740483 on the risk of CHD, and rs1333040-rs1333042-rs4977574 and rs1333040-rs1333042-rs4977574-rs2740483 on the risk of IS were relatively weak.
|
27096864 |
2016 |
|
rs1239681664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current meta-analysis suggests that ABCB1 C3435T polymorphism may contribute to the risk of CHD, especially for MI and ACS, among Caucasian populations.
|
24328528 |
2014 |
|
rs2066714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated 244 unrelated, consecutively enrolled patients with ischemic stroke, 150 patients with coronary heart disease (CHD) and 193 blood donors for allele frequencies (AFs) of three common ABCA1 polymorphisms (R219K, V771M and I883M).
|
16446539 |
2006 |
|
rs2066718
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data confirm earlier observations that ABCA1 R219K and V771M polymorphisms may be associated with a protective role against CHD and extend those to another important pathologic condition, namely stroke.
|
16446539 |
2006 |
|
rs532997003
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The multivariate model included 512 men with coronary artery disease from the REGRESS study who were completely genotyped for eight polymorphisms selected in the univariate procedure (ie, APOA1 G(-75)A, ABCA1 C(-477)T, ABCA1 G1051A, APOC3 T3206G, APOE Arg158Cys, LIPC C(-514)T, LPL Asn291Ser and LPL Ser447Stop).
|
15657615 |
2005 |