rs11175593
|
|
|
0.820 |
GeneticVariation |
BEFREE |
CD susceptibility polymorphisms ATG16L1 rs2241880, ICAM1 rs5498, IL4 rs2070874, IL17F rs763780, IRGM rs13361189, ITLN1 rs2274910, LRRK2 rs11175593, and TLR4 rs4986790 were genotyped in a Portuguese population (511 CD patients, 626 controls) and assessed for association with CD clinical characteristics.
|
22573572 |
2013 |
rs11175593
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Genome-wide association studies (GWAS) in Crohn's disease (CD) have identified associations with single-nucleotide polymorphism (SNP) rs11175593 at chromosome 12q12.
|
23619718 |
2013 |
rs11175593
|
|
T |
0.820 |
GeneticVariation |
GWASCAT |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
rs11175593
|
|
T |
0.820 |
GeneticVariation |
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
rs148319899
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
rs7313895
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
rs17466626
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
rs4768236
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
rs3761863
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Interestingly, the M2397T variant was reported in association with Crohn's disease with the same risk allele as in T1R suggesting common inflammatory mechanism in these two distinct diseases.
|
26844546 |
2016 |
rs3761863
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The genotype underlying this eQTL is in strong linkage disequilibrium with the CD associated non-synonymous SNP rs3761863 (M2397T).
|
23967090 |
2013 |
rs33995883
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The <i>LRRK2</i> N2081D CD risk allele is located in the same kinase domain as G2019S, a mutation that is the major genetic cause of familial and sporadic PD.
|
29321258 |
2018 |
rs34637584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The <i>LRRK2</i> N2081D CD risk allele is located in the same kinase domain as G2019S, a mutation that is the major genetic cause of familial and sporadic PD.
|
29321258 |
2018 |
rs7133914
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected association signals in the <i>LRRK2</i> gene that conferred risk for CD (N2081D variant, <i>P</i> = 9.5 × 10<sup>-10</sup>) or protection from CD (N551K variant, tagging R1398H-associated haplotype, <i>P</i> = 3.3 × 10<sup>-8</sup>).
|
29321258 |
2018 |
rs7308720
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected association signals in the <i>LRRK2</i> gene that conferred risk for CD (N2081D variant, <i>P</i> = 9.5 × 10<sup>-10</sup>) or protection from CD (N551K variant, tagging R1398H-associated haplotype, <i>P</i> = 3.3 × 10<sup>-8</sup>).
|
29321258 |
2018 |