Gene: IL12B ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3212217
rs3212217
IL12B
0.010 GeneticVariation BEFREE Eight functional SNPs were associated with anti-TNF response either among patients with CD (TLR5 (rs5744174) and IFNGR2 (rs8126756)), UC (IL12B (rs3212217), IL18 (rs1946518), IFNGR1 (rs2234711), TBX21 (rs17250932) and JAK2 (rs12343867)) or in the combined cohort of patient with CD and UC (IBD) (NLRP3 (rs10754558), IL12B (rs3212217) and IFNGR1 (rs2234711)) (P<0.05). 28139755

2018
dbSNP: rs2288831
rs2288831
IL12B ; LOC107986469
0.010 GeneticVariation BEFREE This study is first to identify SNP rs2288831 in the IL12B gene as a susceptible variation for CD. 23573954

2013
dbSNP: rs919766
rs919766
IL12B ; LOC107986469
0.010 GeneticVariation BEFREE This significant association with CD was also observed for a haplotype consisting of SNP rs919766 and rs2288831 (odds ratio = 1.29; 95% confidence interval 1.03-1.60; P = 0.025). 23573954

2013