Gene: LRRK2 ×
Source: BEFREE ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11175593
rs11175593
LRRK2 ; LINC02471 ; LOC105369735 ; LRRK2-DT
0.820 GeneticVariation BEFREE CD susceptibility polymorphisms ATG16L1 rs2241880, ICAM1 rs5498, IL4 rs2070874, IL17F rs763780, IRGM rs13361189, ITLN1 rs2274910, LRRK2 rs11175593, and TLR4 rs4986790 were genotyped in a Portuguese population (511 CD patients, 626 controls) and assessed for association with CD clinical characteristics. 22573572

2013
dbSNP: rs11175593
rs11175593
LRRK2 ; LINC02471 ; LOC105369735 ; LRRK2-DT
0.820 GeneticVariation BEFREE Genome-wide association studies (GWAS) in Crohn's disease (CD) have identified associations with single-nucleotide polymorphism (SNP) rs11175593 at chromosome 12q12. 23619718

2013
dbSNP: rs3761863
rs3761863
LRRK2 ; LOC105369736
0.020 GeneticVariation BEFREE Interestingly, the M2397T variant was reported in association with Crohn's disease with the same risk allele as in T1R suggesting common inflammatory mechanism in these two distinct diseases. 26844546

2016
dbSNP: rs3761863
rs3761863
LRRK2 ; LOC105369736
0.020 GeneticVariation BEFREE The genotype underlying this eQTL is in strong linkage disequilibrium with the CD associated non-synonymous SNP rs3761863 (M2397T). 23967090

2013
dbSNP: rs33995883
rs33995883
LRRK2
0.010 GeneticVariation BEFREE The <i>LRRK2</i> N2081D CD risk allele is located in the same kinase domain as G2019S, a mutation that is the major genetic cause of familial and sporadic PD. 29321258

2018
dbSNP: rs34637584
rs34637584
LRRK2
0.010 GeneticVariation BEFREE The <i>LRRK2</i> N2081D CD risk allele is located in the same kinase domain as G2019S, a mutation that is the major genetic cause of familial and sporadic PD. 29321258

2018
dbSNP: rs7133914
rs7133914
LRRK2
0.010 GeneticVariation BEFREE We detected association signals in the <i>LRRK2</i> gene that conferred risk for CD (N2081D variant, <i>P</i> = 9.5 × 10<sup>-10</sup>) or protection from CD (N551K variant, tagging R1398H-associated haplotype, <i>P</i> = 3.3 × 10<sup>-8</sup>). 29321258

2018
dbSNP: rs7308720
rs7308720
LRRK2
0.010 GeneticVariation BEFREE We detected association signals in the <i>LRRK2</i> gene that conferred risk for CD (N2081D variant, <i>P</i> = 9.5 × 10<sup>-10</sup>) or protection from CD (N551K variant, tagging R1398H-associated haplotype, <i>P</i> = 3.3 × 10<sup>-8</sup>). 29321258

2018