|
rs1000113
|
|
|
0.840 |
GeneticVariation |
BEFREE |
IRGM rs1000113 and IRGM rs72553867 exhibited associations with early-onset CD as risk loci and defense loci, respectively.
|
25944217 |
2015 |
|
rs1000113
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Significant associations with Crohn's disease were noted with the T allele of rs1000113 (OR 1.46, 95% CI 1.12-1.90), T allele of rs9637876 (OR 1.25, 95% CI 1.005-1.561) and C allele of rs 13361189 (OR 1.33, 95% CI 1.07-1.669).
|
25191865 |
2014 |
|
rs1000113
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Our analysis revealed an association of the IRGM SNPs rs13371189 (p = 0.02, OR 1.31 [95% CI 1.05-1.65]), rs10065172 = p.Leu105Leu (p = 0.016, OR 1.33 [95% CI 1.06-1.66]) and rs1000113 (p = 0.047, OR 1.27 [95% CI 1.01-1.61]) with CD susceptibility.
|
23365659 |
2013 |
|
rs1000113
|
|
|
0.840 |
GeneticVariation |
BEFREE |
We replicated the previously reported associations between CD and rs1000113 and rs4958847, confirming that IRGM is a susceptibility locus only for CD, either adult- or early-onset in the Italian population; furthermore, we have also shown its influence on specific clinical features (fistulizing disease).
|
19098858 |
2009 |
|
rs11747270
|
|
|
0.820 |
GeneticVariation |
BEFREE |
IRGM rs4958847 and rs11747270 increased the risk of developing arthritis in patients with CD.
|
31654602 |
2020 |
|
rs11747270
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Two SNPs--rs11747270 and rs180802994--did not exhibit Hardy-Weinberg equilibrium but were associated with both Crohn's disease and ulcerative colitis in this population.
|
25191865 |
2014 |
|
rs4958847
|
|
|
0.080 |
GeneticVariation |
BEFREE |
IRGM rs4958847 and rs11747270 increased the risk of developing arthritis in patients with CD.
|
31654602 |
2020 |
|
rs4958847
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our study confirms IRGM rs13361189 and rs4958847 polymorphisms to be important for Crohn's disease susceptibility and phenotype modulation, in accordance with previous findings.
|
26066377 |
2015 |
|
rs4958847
|
|
|
0.080 |
GeneticVariation |
BEFREE |
However, the IRGM rs10065172 and rs4958847 polymorphisms may not be the major determinants of CD risk.
|
25526194 |
2014 |
|
rs4958847
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The analysis showed modest significant association for the rs13361189, rs4958847 and rs10065172 variants in Crohn's disease (CD): the risk estimates for the allele contrast were OR=1.306 (1.200-1.420), p=5.2 × 10(-10), OR=1.182 (1.082-1.290), p=0.0002, and OR=1.248 (1.057-1.473), p=0.009 respectively (still significant when the p value was Bonferroni adjusted to 0.017).
|
24232856 |
2013 |
|
rs4958847
|
|
|
0.080 |
GeneticVariation |
BEFREE |
: Single-nucleotide polymorphism rs4958847 in the IRGM gene correlated very significantly with frequency of surgery in patients with ileocolonic Crohn's disease.
|
22228152 |
2012 |
|
rs4958847
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In addition, our meta-analysis data showed that IRGM rs13361189 and rs4958847 polymorphisms were associated with CD (rs13361189 C allele P=1.07 x 10(-19), pooled OR=1.34; rs4958847 A allele P=2.78 x 10(-17), pooled OR=1.31) and UC (rs13361189 P=0.0069, pooled OR=1.16; rs4958847 P=0.014, pooled OR=1.13).
|
19491842 |
2009 |
|
rs4958847
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We replicated the previously reported associations between CD and rs1000113 and rs4958847, confirming that IRGM is a susceptibility locus only for CD, either adult- or early-onset in the Italian population; furthermore, we have also shown its influence on specific clinical features (fistulizing disease).
|
19098858 |
2009 |
|
rs4958847
|
|
|
0.080 |
GeneticVariation |
BEFREE |
NCF4 and IRGM were significantly associated with ileal CD (P-value(rs4821544)=0.0090, odds ratio (OR)=1.425, 95% confidence interval (CI): 1.092-1.859; P-value(rs13361189)=0.0017, OR=1.942, 95% CI: 1.274-2.959; P-value(rs4958847)=0.0022, OR=1.767, 95% CI: 1.224-2.558), but not with other forms of inflammatory bowel disease (IBD).
|
18580884 |
2008 |
|
rs10065172
|
|
|
0.070 |
GeneticVariation |
BEFREE |
However, we observed no correlation between the rs10065172 and rs4958847 polymorphisms in the IRGM gene with susceptibility to CD (all P > 0.05).
|
25526194 |
2014 |
|
rs10065172
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We found a genetic interaction between reference SNP (rs)2241880 (ATG16L1) and rs10065172 (IRGM) in CD.
|
24247223 |
2013 |
|
rs10065172
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The analysis showed modest significant association for the rs13361189, rs4958847 and rs10065172 variants in Crohn's disease (CD): the risk estimates for the allele contrast were OR=1.306 (1.200-1.420), p=5.2 × 10(-10), OR=1.182 (1.082-1.290), p=0.0002, and OR=1.248 (1.057-1.473), p=0.009 respectively (still significant when the p value was Bonferroni adjusted to 0.017).
|
24232856 |
2013 |
|
rs10065172
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Our analysis revealed an association of the IRGM SNPs rs13371189 (p = 0.02, OR 1.31 [95% CI 1.05-1.65]), rs10065172 = p.Leu105Leu (p = 0.016, OR 1.33 [95% CI 1.06-1.66]) and rs1000113 (p = 0.047, OR 1.27 [95% CI 1.01-1.61]) with CD susceptibility.
|
23365659 |
2013 |
|
rs10065172
|
|
|
0.070 |
GeneticVariation |
BEFREE |
This is the first study to identify SNP rs10065172 and rs72553867 in IRGM as principal CD susceptibility loci in an Asian population.
|
22508677 |
2013 |
|
rs10065172
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Our analysis revealed an association of the IRGM SNPs rs13371189 (p = 0.02, OR 1.31 [95% CI 1.05-1.65]), rs10065172 = p.Leu105Leu (p = 0.016, OR 1.33 [95% CI 1.06-1.66]) and rs1000113 (p = 0.047, OR 1.27 [95% CI 1.01-1.61]) with CD susceptibility.
|
23365659 |
2013 |
|
rs10065172
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Susceptibility to Crohn disease (CD), an inflammatory bowel disease, is influenced by common variants at many loci like the exonic synonymous IRGM SNP (rs10065172, NM_001145805.1, c.313C>T).
|
21508684 |
2011 |
|
rs10065172
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1.54; 95% confidence interval, 1.17-2.02; P<0.01) compared to controls.
|
21283700 |
2011 |
|
rs72553867
|
|
|
0.030 |
GeneticVariation |
BEFREE |
SNPs rs72553867 (IRGM gene), rs4409764 (NKX2-3 gene), and rs3731772 (AOX1 gene) increase the risk of pCD.
|
31844038 |
2019 |
|
rs72553867
|
|
|
0.030 |
GeneticVariation |
BEFREE |
IRGM rs1000113 and IRGM rs72553867 exhibited associations with early-onset CD as risk loci and defense loci, respectively.
|
25944217 |
2015 |
|
rs72553867
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This is the first study to identify SNP rs10065172 and rs72553867 in IRGM as principal CD susceptibility loci in an Asian population.
|
22508677 |
2013 |