|
rs3810936
|
|
|
0.850 |
GeneticVariation |
BEFREE |
For example, we characterized that the Crohn's disease risk variant for rs3810936 increases NFKB1 binding and results in altered gene expression.
|
30254052 |
2018 |
|
rs3810936
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Our analysis suggested that rs3810936 polymorphism was significantly associated with decreased risk of Crohn's disease (CD) and ulcerative colitis (UC).
|
29873318 |
2018 |
|
rs3810936
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Our results confirmed a significant association of CD with the following previously reported risk loci: rs3810936 in TNFSF15 (OR=1.83, p<2.2×10(-16)), rs76418789 in IL23R (OR=0.47, p=1.14×10(-8)) and rs2241880 in ATG16L1 (OR=1.30, p=5.28×10(-6)).
|
25731871 |
2016 |
|
rs3810936
|
|
|
0.850 |
GeneticVariation |
BEFREE |
The minor T alleles and the TT genotypes of rs10114470 and rs3810936 were significantly protectively associated with both CD and UC.
|
25501099 |
2014 |
|
rs3810936
|
|
|
0.850 |
GeneticVariation |
BEFREE |
According to the subgroup analysis by ethnicity, except for rs4263839 in Caucasian and rs4979462 in Asian, all the rest investigated TNFSF15 polymorphisms were associated with CD risk and rs3810936 and rs7848647 polymorphism in Asian as well as rs6478108 polymorphism in Caucasian were associated with UC risk.
|
25028192 |
2014 |
|
rs7848647
|
|
|
0.840 |
GeneticVariation |
BEFREE |
For rs7848647 polymorphism, significantly protective association between this polymorphism and CD risk was also observed, but not in UC.
|
29873318 |
2018 |
|
rs7848647
|
|
|
0.840 |
GeneticVariation |
BEFREE |
The CC genotype of rs6478108, AA genotype of rs4263839, the AA genotype of rs6478109, the TT genotype of rs7848647 and the CC genotype of rs7869487 were all protectively associated with CD but not with UC.
|
25501099 |
2014 |
|
rs7848647
|
|
|
0.840 |
GeneticVariation |
BEFREE |
According to the subgroup analysis by ethnicity, except for rs4263839 in Caucasian and rs4979462 in Asian, all the rest investigated TNFSF15 polymorphisms were associated with CD risk and rs3810936 and rs7848647 polymorphism in Asian as well as rs6478108 polymorphism in Caucasian were associated with UC risk.
|
25028192 |
2014 |
|
rs7848647
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Carriers of three polymorphisms, including rs3810936, rs6478108, and rs7848647, showed statistically significant association with CD (adjusted OR [aOR] 2.81, 95% confidence interval [CI] 1.94-4.07, P= 4.4 x 10(-8); aOR 3.49, 95% CI 2.42-5.04, P= 2.7 x 10(-11); and aOR 3.49, 95% CI 2.42-5.03, P= 2.2 x 10(-11), respectively).
|
18422820 |
2008 |
|
rs6478109
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Using genetic data from published studies on CD, PBC and leprosy we revealed that bearing a T allele at rs6478108/rs6478109 (r(2) = 1) or rs4979462 was significantly associated with increased risk of CD and decreased risk of leprosy, while the T allele at rs4979462 was associated with significantly increased risk of PBC.
|
27507062 |
2016 |
|
rs4263839
|
|
|
0.830 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that most of the seven TNFSF15 polymorphisms (except for rs4263839) were risk factors contributed to CD and UC susceptibility.
|
25028192 |
2014 |
|
rs4263839
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Among the TNFSF15 SNPs, rs4263839 associated with CD in Taiwan (P = 0.005), haplotype analysis did not increase the association.
|
24783249 |
2014 |
|
rs6478109
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Except for rs4263839 polymorphism, significant associations were found between the rest six TNFSF15 polymorphisms and CD risk (rs3810936: OR = 2.10, 95% CI, 1.47-3.00; rs6478108: OR = 2.19, 95% CI, 1.53-3.13; rs4979462: OR = 1.89, 95% CI, 1.42-2.52; rs6478109: OR = 2.00, 95% CI, 1.39-2.88; rs7848647: OR = 1.54, 95% CI, 1.15-2.06; rs7869487: OR = 1.51, 95% CI, 1.06-2.17).
|
25028192 |
2014 |
|
rs6478109
|
|
|
0.830 |
GeneticVariation |
BEFREE |
The CC genotype of rs6478108, AA genotype of rs4263839, the AA genotype of rs6478109, the TT genotype of rs7848647 and the CC genotype of rs7869487 were all protectively associated with CD but not with UC.
|
25501099 |
2014 |
|
rs4263839
|
|
|
0.830 |
GeneticVariation |
BEFREE |
The Crohn's disease risk allele rs4263839 G in the TNFSF15 gene was significantly associated with an increased risk of both IBS (p=2.2×10(-5); OR 1.37) and more pronouncedly, IBS-C (p=8.7×10(-7); OR 1.79) in the entire sample.
|
21636646 |
2011 |
|
rs6478108
|
|
|
0.760 |
GeneticVariation |
BEFREE |
For rs6478108 polymorphism, we also detected a significantly protective association with CD risk in all genetic model but not in UC.
|
29873318 |
2018 |
|
rs6478108
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Using genetic data from published studies on CD, PBC and leprosy we revealed that bearing a T allele at rs6478108/rs6478109 (r(2) = 1) or rs4979462 was significantly associated with increased risk of CD and decreased risk of leprosy, while the T allele at rs4979462 was associated with significantly increased risk of PBC.
|
27507062 |
2016 |
|
rs6478108
|
|
|
0.760 |
GeneticVariation |
BEFREE |
The CC genotype of rs6478108, AA genotype of rs4263839, the AA genotype of rs6478109, the TT genotype of rs7848647 and the CC genotype of rs7869487 were all protectively associated with CD but not with UC.
|
25501099 |
2014 |
|
rs6478108
|
|
|
0.760 |
GeneticVariation |
BEFREE |
According to the subgroup analysis by ethnicity, except for rs4263839 in Caucasian and rs4979462 in Asian, all the rest investigated TNFSF15 polymorphisms were associated with C</span>D risk and rs3810936 and rs7848647 polymorphism in Asian as well as rs6478108 polymorphism in Caucasian were associated with UC risk.
|
25028192 |
2014 |
|
rs6478108
|
|
|
0.760 |
GeneticVariation |
BEFREE |
A total of 666 IBD families (corresponding to 2,982 relatives) with European ancestry were genotyped for the rs6478108 and rs7869487 polymorphisms, which define the main TNFSF15 haplotypes previously associated with CD.
|
19174806 |
2009 |
|
rs6478108
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Carriers of three polymorphisms, including rs3810936, rs6478108, and rs7848647, showed statistically significant association with CD (adjusted OR [aOR] 2.81, 95% confidence interval [CI] 1.94-4.07, P= 4.4 x 10(-8); aOR 3.49, 95% CI 2.42-5.04, P= 2.7 x 10(-11); and aOR 3.49, 95% CI 2.42-5.03, P= 2.2 x 10(-11), respectively).
|
18422820 |
2008 |
|
rs4979462
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Using genetic data from published studies on CD, PBC and leprosy we revealed that bearing a T allele at rs6478108/rs6478109 (r(2) = 1) or rs4979462 was significantly associated with increased risk of CD and decreased risk of leprosy, while the T allele at rs4979462 was associated with significantly increased risk of PBC.
|
27507062 |
2016 |
|
rs4979462
|
|
|
0.720 |
GeneticVariation |
BEFREE |
According to the subgroup analysis by ethnicity, except for rs4263839 in Caucasian and rs4979462 in Asian, all the rest investigated TNFSF15 polymorphisms were associated with CD risk and rs3810936 and rs7848647 polymorphism in Asian as well as rs6478108 polymorphism in Caucasian were associated with UC risk.
|
25028192 |
2014 |
|
rs10114470
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The minor T alleles and the TT genotypes of rs10114470 and rs3810936 were significantly protectively associated with both CD and UC.
|
25501099 |
2014 |