Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE 5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the serotonin (5-HT) transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene, impact on two distinct, but interacting signaling systems, which have been related to depression and to the modulation of neurogenesis and plasticity of circuitries of emotion processing. 18347599

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Depression in multiple sclerosis: effect of brain derived neurotrophic factor Val66Met polymorphism and disease perception. 26756166

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE A brain-derived neurotrophic factor (BDNF) prodomain single-nucleotide polymorphism resulting in a valine to methionine substitution (Val66Met) has been associated with depression-related phenotypes and brain alterations involving regions consistently associated with major depressive disorder (MDD). 23165919

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE A functional BDNF polymorphism (BDNF Val66Met) was reported to influence the effects of stressful life events or childhood adversity on depression and suicidal behaviour in various psychopathologies. 20667416

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Additionally, the association between DED and Val66Met may vary by depression status. 26393465

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression. 17911362

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity. 18721847

2009

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Association of Val66Met polymorphism at brain derived neurotrophic factor gene with depression among Chinese adolescents after Wenchuan earthquake: An 18months longitudinal study. 28527683

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms. 27852165

2017

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Associations between the BDNF val66met polymorphism and both depression status and treatment response were investigated using logistic regression models. 26795846

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Assuming that BDNF may be implicated in the putative common pathophysiology of depression and anxiety, we analyzed the association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (formerly named C270T) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with panic disorder. 15913870

2005

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE BDNF Val66Met genotype and 6-month remission rates in late-life depression. 20195291

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Both the functional Val66Met BDNF polymorphism (rs6265) and BDNF levels have been associated with depression. 23303061

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Decreased serum brain-derived neurotrophic factor (BDNF) is associated with post-stroke depression but not with BDNF gene Val66Met polymorphism. 21143020

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Discussion The dynamics of serum BDNF levels, but not plasma levels of HVA and MHPG, reflect the response to mirtazapine treatment; the BDNF Val66Met polymorphism in patients with depression is, however, associated with neither a particular response to mirtazapine treatment nor baseline serum BDNF levels. 22883353

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Early life stress combined with serotonin 3A receptor and brain-derived neurotrophic factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depression. 20728877

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Furthermore, the sex-specific genotype effects may contribute to sex-specific effects of BDNF Val66Met on depression vulnerability. 20097294

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Given that BDNF secretion is affected by a common polymorphism (rs6265, Val66Met), which also is associated with depression, we investigated whether this polymorphism modifies the effect of childhood adversity (CA) on local gray matter (GM) volume in depression-relevant brain regions, using data from two large cohorts of healthy subjects. 21577214

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Here, we determined the effects of the BDNF Val66met polymorphism on the five-factor personality dimensions (assessed using the NEO-FFI), trait depression (assessed with the DASS-21) in a cross-sectional cohort of 467 healthy volunteers. 18548532

2009

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE I will also review key studies, both human and animal, which have investigated the association of a BDNF single-nucleotide polymorphism (Val66Met) with depression pathogenesis, and detail the number of inconsistencies which also afflict this novel area of BDNF research. 17700574

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Imaging genetics studies have investigated the influence of the serotonin transporter-linked polymorphic region (5HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on the hippocampus in healthy individuals and patients with depression (MDD). 21692988

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE In 732 Korean community residents ages 65+, diagnosis of depression (Geriatric Mental State Schedule), information on SLEs, and genotypes for 5-HTTLPR and BDNF val66met were ascertained. 17482146

2007

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE In the total sample, the BDNF Val66Met polymorphism was not significantly associated with depression. 18852698

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression. 22931410

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Interaction between stress and the BDNF Val66Met polymorphism in depression: a systematic review and meta-analysis. 24433458

2014