Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression. 17941097

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Both the functional Val66Met BDNF polymorphism (rs6265) and BDNF levels have been associated with depression. 23303061

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The polymorphism BDNF val66met of the brain derived neurotrophic factor (BDNF) is common, may increase the risk for depression, and affects BDNF secretion, critical for neuronal survival, plasticity, neurogenesis, and synaptic connectivity. 20346518

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Two recent papers associated candidate genes with brooding rumination, a possible cognitive endophenotype for depression, in children ages 8-14 years.Stone et al. reported that BDNF val66met polymorphism predicted brooding in adolescence.Woody et al. reported that children carrying at least one copy of a CRHR1 TAT haplotype reported less brooding than their peers in the presence of maternal depression. 27073970

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The meta-analysis of Val66Met in depression obtained an overall summary OR of 1.06 (95% CI: 0.89-1.26, P = 0.537) comparing MM with VV genotypes and an OR of 0.97 (95% CI: 0.89-1.05, P = 0.403) comparing MV with VV genotypes. 18205169

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Modulatory effects of the BDNF Val66Met polymorphism on distinct subregions in the prefrontal cortex in MDD support the neurotrophin model of depression. 25745134

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity. 18721847

2009

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Given that BDNF secretion is affected by a common polymorphism (rs6265, Val66Met), which also is associated with depression, we investigated whether this polymorphism modifies the effect of childhood adversity (CA) on local gray matter (GM) volume in depression-relevant brain regions, using data from two large cohorts of healthy subjects. 21577214

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Interaction between stress and the BDNF Val66Met polymorphism in depression: a systematic review and meta-analysis. 24433458

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We investigated the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the severity of depressive and anxiety symptoms in never-smokers, former smokers, non-dependent, and nicotine-dependent smokers with a current diagnosis of depression and/or anxiety. 25618300

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE I will also review key studies, both human and animal, which have investigated the association of a BDNF single-nucleotide polymorphism (Val66Met) with depression pathogenesis, and detail the number of inconsistencies which also afflict this novel area of BDNF research. 17700574

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Depression in multiple sclerosis: effect of brain derived neurotrophic factor Val66Met polymorphism and disease perception. 26756166

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: associations with cognitive vulnerability to depression in childhood. 23880378

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We therefore examined whether the single-nucleotide polymorphism producing a valine-to-methionine substitution at codon 66 (val66met) of the BDNF gene was associated with childhood NE, in the context of parental depression and relationship discord. 20921572

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study. 23481907

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression. 18263664

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE This study aimed to investigate whether BDNF gene promoter methylation status and val66met polymorphism were associated with depression ascertained at two weeks and one year after stroke. 23399480

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Additionally, the association between DED and Val66Met may vary by depression status. 26393465

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The influence of 5-HTTLPR and Val66Met polymorphisms on cortical thickness and volume in limbic and paralimbic regions in depression: a preliminary study. 26976307

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Furthermore, the sex-specific genotype effects may contribute to sex-specific effects of BDNF Val66Met on depression vulnerability. 20097294

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE A functional BDNF polymorphism (BDNF Val66Met) was reported to influence the effects of stressful life events or childhood adversity on depression and suicidal behaviour in various psychopathologies. 20667416

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects. 21420735

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE In the total sample, the BDNF Val66Met polymorphism was not significantly associated with depression. 18852698

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents. 21037213

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. 19153574

2009