|
rs1799983
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The aim of this study is to quantify global DNA methylation and investigate the relationship with diabetes status and polymorphisms in MTHFR C677T and NOS3 G894T genes in mixed ancestry subjects from South Africa.
|
27990443 |
2016 |
|
rs1799983
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Although the NOS3 G894T variant was not independently associated with diabetes in either African Americans or whites, significant interaction between BMI and the NOS3 polymorphism indicated that obesity was an effect modifier of diabetes risk for white individuals with the TT genotype (odds ratio (OR) for interaction = 1.65, p = 0.04).
|
24278136 |
2013 |
|
rs1799983
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In the present study we genotyped 894G>T in the cohort of prospectively followed type 2 diabetics with the aim to investigate its possible role in the progression of DN and development of morbidity and mortality associated with diabetes.
|
24603156 |
2013 |
|
rs1799983
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Regarding the eNOS E298D polymorphism, the frequency of the mutant D allele carriage was only observed to be higher among cases with hypertension associated with diabetes and obesity, in comparison with controls, yet not reaching statistical significance (41.2% vs. 34%, p > 0.05).
|
23042814 |
2013 |
|
rs1799983
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To determine the frequency of eNOS G894T variant and to find the possible association between this polymorphism with CAD we studied 207 unrelated patients with total CAD (with and without diabetes) and 92 controls.
|
21602253 |
2012 |
|
rs1799983
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The meta-analysis showed that G894T is significantly associated with diabetic nephropathy and diabetes leading to severe nephropathy in type 2 diabetics and in East Asians, respectively.
|
19773668 |
2009 |
|
rs1799983
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In contrast, the T allele is associated with increased oxidative stress in the renal circulation in patients with diabetes suggesting a specific role of the G894T polymorphism in the pathogenesis of diabetic nephropathy.
|
18622262 |
2008 |
|
rs1799983
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The frequency of CC (-786T > C), TT (894G > T) and aa genotypes (27VNTR) were significantly higher in diabetic nephropathy patients as compared to the diabetes without nephropathy group (CC: P = 0.003, TT: P = 0.03, aa: P < 0.0001).
|
18401556 |
2008 |
|
rs1799983
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Age at onset of diabetes, male sex, duration of diabetes, HbA1c, blood pressure and smoking were assessed as possible confounders in the logistic regression analysis, which showed that homozygosity for the Glu-allele of the Glu298Asp-polymorphism was independently associated with increased risk of DN (OR = 1.46; 95% CI = 1.12-1.91).
|
17101543 |
2006 |
|
rs11771443
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These preliminary findings indicate that the NOS2 rs2779248, NOS2 rs1137933, and NOS3 rs3918188 genetic polymorphisms are potentially related to the susceptibility to T2DM, and the rs1800783 polymorphism might be considered as genetic risk factors for diabetic nephropathy, and family history of diabetes was closely associated with rs11771443 polymorphism in DN, and the genetic variants might be used as molecular markers for evaluating the risk of T2DM and diabetic nephropathy.© 2016 IUBMB Life, 68(7):516-525, 2016.
|
27192959 |
2016 |
|
rs1800783
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These preliminary findings indicate that the NOS2 rs2779248, NOS2 rs1137933, and NOS3 rs3918188 genetic polymorphisms are potentially related to the susceptibility to T2DM, and the rs1800783 polymorphism might be considered as genetic risk factors for diabetic nephropathy, and family history of diabetes was closely associated with rs11771443 polymorphism in DN, and the genetic variants might be used as molecular markers for evaluating the risk of T2DM and diabetic nephropathy.© 2016 IUBMB Life, 68(7):516-525, 2016.
|
27192959 |
2016 |
|
rs375752214
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study is to quantify global DNA methylation and investigate the relationship with diabetes status and polymorphisms in MTHFR C677T and NOS3 G894T genes in mixed ancestry subjects from South Africa.
|
27990443 |
2016 |
|
rs3918188
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These preliminary findings indicate that the NOS2 rs2779248, NOS2 rs1137933, and NOS3 rs3918188 genetic polymorphisms are potentially related to the susceptibility to T2DM, and the rs1800783 polymorphism might be considered as genetic risk factors for diabetic nephropathy, and family history of diabetes was closely associated with rs11771443 polymorphism in DN, and the genetic variants might be used as molecular markers for evaluating the risk of T2DM and diabetic nephropathy.© 2016 IUBMB Life, 68(7):516-525, 2016.
|
27192959 |
2016 |