|
rs370443546
|
|
|
0.020 |
GeneticVariation |
BEFREE |
M55V variant of SUMO4 was significantly associated with type 1 diabetes in Asians, but genetic heterogeneity between Asian and Caucasian populations was suggested.
|
17130532 |
2006 |
|
rs11571316
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
|
21980299 |
2011 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between IL-18 gene promoter polymorphisms and CTLA-4 gene 49A/G polymorphism in Japanese patients with type 1 diabetes.
|
14709415 |
2004 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with Type 1 Diabetes in Croatians.
|
19815302 |
2009 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CTLA-4 49 A/G dimorphism and type 1 diabetes susceptibility: a French case-control study and segregation analysis. Evidence of a maternal effect.
|
12047362 |
2002 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CTLA4 rs231775 and TNF-αrs1800629 were not associated with T1D onset in the Brazilian population.
|
26782543 |
2015 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Evaluated was the role of the CTLA4 exon 1 A49G polymorphism and its role as a risk factor for T1D in our population.
|
15301861 |
2004 |
|
rs3087243
|
|
G |
0.860 |
GeneticVariation |
GWASCAT |
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
|
25751624 |
2015 |
|
rs3087243
|
|
|
0.860 |
GeneticVariation |
BEFREE |
For the case-control studies, 1) the rs3087243 polymorphism was significantly associated with T1D [allele (fixed: odds ratio and 95% confidence interval (CI) = 1.249 (1.194-1.307), P < 0.001; random: odds ratio and 95%CI = 1.601 (1.103-2.325), P = 0.013)] [genotype (GG versus GA+AA: odds ratio and 95%CI = 1.249 (1.164-1.341), P < 0.001)], 2) there was no evidence to show that this association was accounted for in any study, and 3) there was no evidence for publication bias.
|
24390983 |
2013 |
|
rs5742909
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further subgroup analyses revealed that rs231775 polymorphism was significantly associated with susceptibility to T1DM in Caucasians and South Asians, and rs5742909 polymorphism was significantly associated with susceptibility to T1DM in South Asians.
|
30988065 |
2019 |
|
rs3087243
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Genetic polymorphisms (HLA haplotypes; rs231806, rs231775, and rs3087243 in CTLA4; rs763361 in CD226; and rs706778 in CD25) and T1D-associated autoantibodies were analyzed.
|
25980680 |
2015 |
|
rs3087243
|
|
A |
0.860 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
rs3087243
|
|
|
0.860 |
GeneticVariation |
GWASCAT |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
rs3087243
|
|
|
0.860 |
GeneticVariation |
GWASDB |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
rs3087243
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Here, we analysed the effect of T1D-associated major HLA class II haplotypes and seven single nucleotide polymorphisms in six non-HLA genes [INS (rs689), PTPN22 (rs2476601), IL2RA (rs12722495 and rs2104286), PTPN2 (rs45450798), CTLA4 (rs3087243) and ERBB3 (rs2292239)] on peripheral blood Treg frequencies.
|
31808541 |
2019 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a combined analysis, the summary per-allele odds ratio (OR) for T1D of the G49A and C60T polymorphism was 1.42 [95% confidence interval (CI): 1.31-1.53, P<10(-5)] and 1.23 (95% CI: 1.18-1.29, P<10(-5)), respectively.
|
24465825 |
2014 |
|
rs3087243
|
|
|
0.860 |
GeneticVariation |
BEFREE |
In the case-only statistical interaction analysis between rs3772534 and rs3087243, there was also no support for an effect (1994 T1D affected offspring, and 3215 cases, P=0.92).
|
17209142 |
2007 |
|
rs3087243
|
|
A |
0.860 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
|
rs3087243
|
|
A |
0.860 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, rs231775 polymorphism was also found to be significantly associated with susceptibility to type 2 diabetes mellitus (T2DM) in East Asians and South Asians.<b>Conclusions:</b> Our findings indicated that rs231775 and rs5742909 polymorphisms may serve as genetic biomarkers of T1DM, and rs231775 polymorphism may also serve as a genetic biomarker of T2DM.
|
30988065 |
2019 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data indicate that CTLA-4 exon 1 position 49 A/G dimorphism was significantly associated with predisposition to IDDM in our Central Poland population, particularly in patients lacking the strongly predisposing DRB1 alleles.
|
9690057 |
1998 |
|
rs370443546
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Studies on IDDM5 have led to the discovery of a novel polymorphism 163 A-->G (M55V) in SUMO4 gene, which was found to be associated with T1D patients with Asian origin.
|
17448564 |
2007 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The 49A/G dimorphism in exon 1 and the (AT)n in the 3' untranslated region of the CTLA-4 gene were significantly associated with type 1 diabetes.
|
11685455 |
2001 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The authors performed a meta-analysis of 33 studies examining the association of type 1 diabetes mellitus with polymorphisms in the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene, including the A49G (29 comparisons), C(-318)T (three comparisons), and (AT)n microsatellite (six comparisons) polymorphisms.
|
15961581 |
2005 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The CTLA-4 49 A/G polymorphism was detected by the PCR-restriction fragment-length polymorphism (RFLP) method in 97 type 1 diabetic subjects and 20 patients with Graves' disease, a cohort which included 4 patients who also had type 1 diabetes.
|
12610047 |
2003 |