|
rs3087243
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Here, we analysed the effect of T1D-associated major HLA class II haplotypes and seven single nucleotide polymorphisms in six non-HLA genes [INS (rs689), PTPN22 (rs2476601), IL2RA (rs12722495 and rs2104286), PTPN2 (rs45450798), CTLA4 (rs3087243) and ERBB3 (rs2292239)] on peripheral blood Treg frequencies.
|
31808541 |
2019 |
|
rs3087243
|
|
G |
0.860 |
GeneticVariation |
GWASCAT |
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
|
25751624 |
2015 |
|
rs3087243
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Genetic polymorphisms (HLA haplotypes; rs231806, rs231775, and rs3087243 in CTLA4; rs763361 in CD226; and rs706778 in CD25) and T1D-associated autoantibodies were analyzed.
|
25980680 |
2015 |
|
rs3087243
|
|
|
0.860 |
GeneticVariation |
BEFREE |
For the case-control studies, 1) the rs3087243 polymorphism was significantly associated with T1D [allele (fixed: odds ratio and 95% confidence interval (CI) = 1.249 (1.194-1.307), P < 0.001; random: odds ratio and 95%CI = 1.601 (1.103-2.325), P = 0.013)] [genotype (GG versus GA+AA: odds ratio and 95%CI = 1.249 (1.164-1.341), P < 0.001)], 2) there was no evidence to show that this association was accounted for in any study, and 3) there was no evidence for publication bias.
|
24390983 |
2013 |
|
rs3087243
|
|
A |
0.860 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
rs3087243
|
|
|
0.860 |
GeneticVariation |
BEFREE |
With respect to the rs3087243 (+6230G>A) polymorphism of CTLA4, the first sister had type 1 diabetes and AITD and had the GG genotype, whereas the second and third sisters, who had type 1 diabetes without AITD, had the AG genotype.
|
19506323 |
2009 |
|
rs3087243
|
|
|
0.860 |
GeneticVariation |
GWASCAT |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
rs3087243
|
|
|
0.860 |
GeneticVariation |
GWASDB |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
rs3087243
|
|
A |
0.860 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
|
rs3087243
|
|
A |
0.860 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
|
rs3087243
|
|
|
0.860 |
GeneticVariation |
BEFREE |
These patients had a stronger association with CTLA4 (odds ratio [OR] = 1.49 for the G allele of the single nucleotide polymorphism rs3087243; 95% CI = 1.29-1.72) than did the TPOAbs-negative patients (p = 0.0004; OR = 1.16; 95% CI = 1.10-1.24) or type 1 diabetes patients overall (OR = 1.20; 95% CI = 1.13-1.27).
|
17334650 |
2007 |
|
rs3087243
|
|
|
0.860 |
GeneticVariation |
BEFREE |
In the case-only statistical interaction analysis between rs3772534 and rs3087243, there was also no support for an effect (1994 T1D affected offspring, and 3215 cases, P=0.92).
|
17209142 |
2007 |
|
rs11571316
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
|
21980299 |
2011 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, rs231775 polymorphism was also found to be significantly associated with susceptibility to type 2 diabetes mellitus (T2DM) in East Asians and South Asians.<b>Conclusions:</b> Our findings indicated that rs231775 and rs5742909 polymorphisms may serve as genetic biomarkers of T1DM, and rs231775 polymorphism may also serve as a genetic biomarker of T2DM.
|
30988065 |
2019 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CTLA4 rs231775 and TNF-αrs1800629 were not associated with T1D onset in the Brazilian population.
|
26782543 |
2015 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a combined analysis, the summary per-allele odds ratio (OR) for T1D of the G49A and C60T polymorphism was 1.42 [95% confidence interval (CI): 1.31-1.53, P<10(-5)] and 1.23 (95% CI: 1.18-1.29, P<10(-5)), respectively.
|
24465825 |
2014 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrated that the G allele of rs231775 of CTLA-4 is a risk factor associated with increased T1D susceptibility.
|
23261825 |
2013 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with Type 1 Diabetes in Croatians.
|
19815302 |
2009 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The influence of polymorphisms of INS(-23Hph1), CTLA-4(T17A), and PTPN22(R620W) on development of persistent islet autoimmunity and progression to type 1 diabetes was evaluated by parametric models and by survival analyses.
|
19188433 |
2009 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The authors performed a meta-analysis of 33 studies examining the association of type 1 diabetes mellitus with polymorphisms in the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene, including the A49G (29 comparisons), C(-318)T (three comparisons), and (AT)n microsatellite (six comparisons) polymorphisms.
|
15961581 |
2005 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Evaluated was the role of the CTLA4 exon 1 A49G polymorphism and its role as a risk factor for T1D in our population.
|
15301861 |
2004 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between IL-18 gene promoter polymorphisms and CTLA-4 gene 49A/G polymorphism in Japanese patients with type 1 diabetes.
|
14709415 |
2004 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The CTLA-4 49 A/G polymorphism was detected by the PCR-restriction fragment-length polymorphism (RFLP) method in 97 type 1 diabetic subjects and 20 patients with Graves' disease, a cohort which included 4 patients who also had type 1 diabetes.
|
12610047 |
2003 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We report the association of CTLA-4 A49G variation (cytotoxic T-lymphocyte associated-4) to TID among Filipinos, consistent with some but not all previous reports in other ethnic groups.
|
12185534 |
2002 |
|
rs231775
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CTLA-4 49 A/G dimorphism and type 1 diabetes susceptibility: a French case-control study and segregation analysis. Evidence of a maternal effect.
|
12047362 |
2002 |