rs61839660
|
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
|
25751624 |
2015 |
rs61839660
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data.
|
22293688 |
2012 |
rs61839660
|
|
|
0.800 |
GeneticVariation |
GWASDB |
1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data.
|
22293688 |
2012 |
rs706778
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Genetic polymorphisms (HLA haplotypes; rs231806, rs231775, and rs3087243 in CTLA4; rs763361 in CD226; and rs706778 in CD25) and T1D-associated autoantibodies were analyzed.
|
25980680 |
2015 |
rs706778
|
|
T |
0.750 |
GeneticVariation |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
rs706778
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Using minor allelic comparison, the five investigated SNPs were all observed to have a significant association with T1D: For rs11594656, fixed effect model (FEM) odds ratio (OR) 0.87, 95% confidence interval (CI) 0.83, 0.91; rs2104286, FEM OR 0.81, 95% CI 0.77, 0.85; rs3118470, FEM OR 1.23, 95% CI 1.16, 1.31; rs41295061, random effect model (REM) OR 0.67, 95% CI 0.60, 0.76 and rs706778 FEM OR 1.20, 95% CI 1.08, 1.33.
|
26249556 |
2015 |
rs706778
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Previous investigations have also demonstrated that two intronic SNPs (rs706778 and rs3118470) in the interleukin-2 receptor-alpha (IL2RA) gene were associated with type 1 diabetes in the Japanese population.
|
20615141 |
2010 |
rs706778
|
|
|
0.750 |
GeneticVariation |
BEFREE |
We found evidence of association with acute-onset, but not slow-onset and fulminant, type 1 diabetes for two of the four single-nucleotide polymorphisms genotyped (rs706778 and rs3118470).
|
19106270 |
2009 |
rs706778
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Two of the 12 IL2RA SNPs genotyped (rs706778 and rs3118470) had statistically significant type 1 diabetes association (P = 6.96 x 10(-4) and 8.63 x 10(-4), respectively).
|
17395754 |
2007 |
rs12722495
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Here, we analysed the effect of T1D-associated major HLA class II haplotypes and seven single nucleotide polymorphisms in six non-HLA genes [INS (rs689), PTPN22 (rs2476601), IL2RA (rs12722495 and rs2104286), PTPN2 (rs45450798), CTLA4 (rs3087243) and ERBB3 (rs2292239)] on peripheral blood Treg frequencies.
|
31808541 |
2019 |
rs12722495
|
|
A |
0.710 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
rs3118470
|
|
|
0.070 |
GeneticVariation |
BEFREE |
However, stratification by IL2RA single-nucleotide polymorphisms revealed that T1D subjects with the rs3118470 CC risk variant have Tregs with IL-2 signaling defects and an increased proportion of FOXP3<sup>+</sup>IL-17<sup>+</sup> cells before diagnosis.
|
28053319 |
2017 |
rs3118470
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Using minor allelic comparison, the five investigated SNPs were all observed to have a significant association with T1D: For rs11594656, fixed effect model (FEM) odds ratio (OR) 0.87, 95% confidence interval (CI) 0.83, 0.91; rs2104286, FEM OR 0.81, 95% CI 0.77, 0.85; rs3118470, FEM OR 1.23, 95% CI 1.16, 1.31; rs41295061, random effect model (REM) OR 0.67, 95% CI 0.60, 0.76 and rs706778 FEM OR 1.20, 95% CI 1.08, 1.33.
|
26249556 |
2015 |
rs3118470
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In contrast, the minor C allele at rs3118470 appeared to be significantly associated with the occurrence of T1D (P = 0.003; OR = 1.30; 95% CI = 1.094-1.550).
|
22211793 |
2012 |
rs3118470
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Previous investigations have also demonstrated that two intronic SNPs (rs706778 and rs3118470) in the interleukin-2 receptor-alpha (IL2RA) gene were associated with type 1 diabetes in the Japanese population.
|
20615141 |
2010 |
rs3118470
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We found evidence of association with acute-onset, but not slow-onset and fulminant, type 1 diabetes for two of the four single-nucleotide polymorphisms genotyped (rs706778 and rs3118470).
|
19106270 |
2009 |
rs3118470
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We had previously shown rs3118470 to confer T1D susceptibility in a Canadian dataset, independently of rs41295061 as the major reported locus (p = 5 x 10(-3), after accounting for rs41295061 by conditional regression).
|
19794070 |
2009 |
rs3118470
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Two of the 12 IL2RA SNPs genotyped (rs706778 and rs3118470) had statistically significant type 1 diabetes association (P = 6.96 x 10(-4) and 8.63 x 10(-4), respectively).
|
17395754 |
2007 |
rs2104286
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Here, we analysed the effect of T1D-associated major HLA class II haplotypes and seven single nucleotide polymorphisms in six non-HLA genes [INS (rs689), PTPN22 (rs2476601), IL2RA (rs12722495 and rs2104286), PTPN2 (rs45450798), CTLA4 (rs3087243) and ERBB3 (rs2292239)] on peripheral blood Treg frequencies.
|
31808541 |
2019 |
rs2104286
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A gene-gene interaction in the T1D data were observed between the IL2RA rs2104286 and GIMAP4 rs9640279 (OR 1.52, p = 0.0064) and indicated between INS rs689 and GIMAP5 rs2286899.
|
25964488 |
2015 |
rs2104286
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In contrast, for MS, the stochastic search found two distinct competing models: a single candidate causal variant, tagged by rs2104286 and reported previously using stepwise analysis; and a more complex model with two association signals, one of which was tagged by the major T1D associated rs12722496 and the other by rs56382813.
|
26106896 |
2015 |
rs2104286
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Using minor allelic comparison, the five investigated SNPs were all observed to have a significant association with T1D: For rs11594656, fixed effect model (FEM) odds ratio (OR) 0.87, 95% confidence interval (CI) 0.83, 0.91; rs2104286, FEM OR 0.81, 95% CI 0.77, 0.85; rs3118470, FEM OR 1.23, 95% CI 1.16, 1.31; rs41295061, random effect model (REM) OR 0.67, 95% CI 0.60, 0.76 and rs706778 FEM OR 1.20, 95% CI 1.08, 1.33.
|
26249556 |
2015 |
rs2104286
|
|
|
0.060 |
GeneticVariation |
BEFREE |
This study was aimed to investigate the association of selected IL2RA polymorphisms (rs11594656, rs3118470, rs2104286 and rs7093069) with type 1 diabetes (T1D) in a Polish cohort comprising 445 patients and 671 healthy control subjects.
|
22211793 |
2012 |
rs2104286
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We show that SLE is associated with rs11594656 (P = 3.87 x 10-7) and there is some evidence of association of rs41295061 with AAV (P = 0.0122), which both have prior association with T1D. rs2104286, an MS and T1D - associated SNP in the IL2RA locus, is not associated with either SLE or AAV.
|
19265545 |
2009 |
rs12722496
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, for MS, the stochastic search found two distinct competing models: a single candidate causal variant, tagged by rs2104286 and reported previously using stepwise analysis; and a more complex model with two association signals, one of which was tagged by the major T1D associated rs12722496 and the other by rs56382813.
|
26106896 |
2015 |