rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Albeit small, our study may suggest that other pathways in AT or effects exerted in other tissues might contribute to the Pro12Ala-mediated protection against T2D.
|
30064293 |
2018 |
rs1801282
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
|
29632382 |
2018 |
rs1801282
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found a significant association of Pro12Ala polymorphism of PPARγ2 gene with T2DM, however the genotypes showed statistically significant association only with few clinical parameters including body mass index, total cholesterol, and low-density lipoprotein (P < 0.05).
|
27567620 |
2017 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These findings suggest no significant association of p.Pro12Ala polymorphism with retinopathy in tested type 2 diabetic retinopathy patients as compared to T2DM individuals take as controls.
|
27427939 |
2017 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Particularly, gene polymorphisms in ADIPOQ (rs1501299 and rs17300539), LepR (rs1137101 and rs1045895), IRS2 (rs1805092), GRB14 (rs10195252 and rs3923113) and PPARG (rs1801282) have been associated with overweight and obesity in uncontrolled T2DM.
|
26999420 |
2016 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among type 2 diabetes mellitus SNPs, rs1801282 is of particular interest because (i) it is harbored by peroxisome proliferator-activated receptor-γ2 (PPARγ2), which is the target for thiazolidinediones which are used as antidiabetic drugs, decreasing all-cause mortality in type 2 diabetes mellitus, and (ii) it is associated with insulin resistance and related traits, risk factors for overall mortality in type 2 diabetes mellitus.
|
26956846 |
2016 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The Pro12Ala (rs1801282) polymorphism in peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) has been convincingly associated with insulin resistance (IR) and type 2 diabetes (T2D) among Europeans, in interaction with a high-fat diet.
|
27075119 |
2016 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The meta-analysis of PPARγ2 (rs1801282) showed </span>population-specific association for T2D su</span>sceptibility as opposed to FTO (rs9939609) which showed no difference in population effect toward T2D susceptibility.
|
26243686 |
2016 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Variation in PPARG, but not Pro12Ala, contributes to declining SI and concomitant deterioration in β-cell function in Mexican Americans at risk for T2DM.
|
25584717 |
2015 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes.
|
25974167 |
2015 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ11), rs1801282 (PPARγ), rs10811661 (CDKN2A/2B), rs13266634 (SLC30A8), rs12779790 (CDC123/CAMK1D), rs7903146 (TCF7L2), rs9282541 (ABCA1) and rs13342692 (SLC16A11) polymorphisms in the genetic background of Maya population to associate their susceptibility to develop T2D.
|
25839936 |
2015 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We genotyped PPARγ Pro12Ala polymorphism in subjects with type 2 diabetes mellitus (T2DM).
|
26836268 |
2015 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In a large sample of the Caucasians the rs8192673 of the PGC-1α gene and the rs1801282 of the PPAR-γ gene were associated with waist circumference in subjects with T2DM.
|
25928419 |
2015 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We conducted a case control study to confirm the association of variants rs10885409 of TCF7L2 and Pro12Ala (rs1801282) of PPAR-γ2 with risk of T2DM and related complications in Emirati population of Arab origin.
|
26273662 |
2015 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Hence, our aim was to develop a low-cost method for the validation of PPARG (Pro12Ala, CCA>GCA) SNP (rs1801282) for its association with T2D.
|
25063576 |
2014 |
rs1801282
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Nominal interactions were observed for sleep duration and PPARG rs1801282, CRY2 rs7943320 and HNF1B rs4430796 in influencing risk of type 2 diabetes (p < 0.05).
|
24280871 |
2014 |
rs1801282
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The fat mass and obesity-associated gene (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma 2 gene (PPARG2) rs1801282 polymorphisms are type 2 diabetes mellitus susceptibility gene variants associated with obesity.
|
24969838 |
2014 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We investigated the independent and joint effects of PPARG Pro12Ala</span> and IRS1 Gly972Arg on markers of insulin resistance and T2DM in an African population with elevated risk of T2DM.</span>
|
24447396 |
2014 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In rare families, loss-of-function (LOF) mutations in PPARG are known to cosegregate with lipodystrophy and insulin resistance; in the general population, the common P12A variant is associated with a decreased risk of type 2 diabetes (T2D).
|
25157153 |
2014 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In a Mendelian randomization design, both HOMA-IR (instrumental variables: rs1801282, rs4607103) and βF (instrumental variable: rs4607103) were related to T2DM (p < 0.03-0.01 and p < 0.03, respectively).
|
23161442 |
2013 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The association between PPARG Pro12Ala SNP and increased T2D susceptibility was confirmed, with Pro12 as risk allele.
|
23386649 |
2013 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Meanwhile PPARG-2 Pro12Ala, CDKN2A/2B rs10811661, IGF2BP2 rs4402960, HHEX rs7923837, CDKAL1 rs7754840, EXT2 rs1113132 and SLC30A8 rs13266634 were found to have no significant association with T2D among Arabs.
|
23458876 |
2013 |