rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The variant allele of the Gly482Ser polymorphism in peroxisome proliferator-activated receptor-gamma co-activator-1alpha (PPARGC1A or PGC1alpha), a critical determinant of skeletal muscle metabolism, has been associated with obesity and type 2 diabetes.
|
16474966 |
2006 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The prevalent Gly482Ser variant in PGC-1 was shown to be associated with type 2 diabetes in some but not all studies.
|
15146371 |
2004 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Together, these results showed that PPARG Pro12Ala and PPARGC1A Gly482Ser variants are associated, alone and in interaction, with insulin and glucose homeostasis and suggest that gene-gene interactions should be taken into account in candidate gene studies of T2DM to identify subjects with markedly different risks of developing the disease.
|
19536736 |
2009 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to analyse the association between PPARG rs1801282, PPARGC1A rs8192678, VEGFA rs2010963, ADRA2A rs553668, KCNQ1 rs2237892, SIRT1 rs7896005, IGF2BP2 rs4402960, and UCP3 rs3781907 single nucleotide variants (SNVs) with T2D and metabolic traits in a case-control study of a population from Mexico City.
|
29800730 |
2018 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this series, there was no association between G482S polymorphism and T2DM and obesity (body mass index >25 kg/m(2)).
|
19913841 |
2010 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analyses conducted on rs8192678 and rs2970847 variants illustrated the overall effect of minor alleles providing a higher risk for the T2D development.
|
29063962 |
2018 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that Gly482Ser and Thr394Thr polymorphisms of PPARGC1A gene were significantly associated with the risk of T2DM, especially in the Indian population.
|
21294239 |
2011 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Gly482Ser genotype distribution in patients with type 2 diabetes</span> (AA = 11.5%, AG = 42.3%, GG = 46.2%) differed from genotype distribution in non-diabetic controls (AA = 6.3%, AG = 46.3%, GG = 47.5%), and the AA genotype was associated with 1.9-times increased risk of type 2 diabetes (95% confidence interval 1.0-3.6; P = 0.036).
|
15581067 |
2004 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Under an additive genetic model, the C allele of ADRB3-rs4994, the C allele of ENPP1-rs1044498, and the A allele of PPARGC1A-rs8192678 increase the risk of type 2 diabetes in the Chinese Han population.
|
22391941 |
2012 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, we examined whether this G</span>ly482Ser polymorphism is associated with type 2 diabetes or obesity, or metabolic predictors of these diseases, in Pima Indians.
|
12606537 |
2003 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We therefore investigated if PPARGC1A expression is altered in islets from patients with type 2 diabetes and whether this expression is influenced by genetic (PPARGC1A Gly482Ser polymorphism) and epigenetic (DNA methylation) factors.
|
18270681 |
2008 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These data suggest that the PGC-1α Thr394Thr and Gly482Ser polymorphisms are associated with therapeutic efficacy of multiple-dose rosiglitazone in Chinese patients with type 2 diabetes mellitus.
|
20498286 |
2010 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies suggested linkage between the chromosomal region of PGC-1alpha and fasting serum insulin levels, and associates a Gly482Ser polymorphism of the gene with type 2 diabetes and hypertension.
|
15649578 |
2005 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Thr394Thr - Gly482Ser haplotype was associated with Type II diabetes (p = 0.00003).CONCLUSION/INTERPRETATION.
|
12107756 |
2002 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There were no associations of the G482S and +1302G>A polymorphisms and haplotype combinations with essential hypertension and type 2 diabetes.
|
15824463 |
2004 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus.
|
22684233 |
2012 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the subgroup analysis, we identified a significant association between PGC-1<i>α</i> rs8192678</span> polymorphism and T2DM in the Caucasian and Indian populations under all genetic models we investigated.
|
30944665 |
2019 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Common polymorphisms of the peroxisome proliferator-activated receptor-gamma (Pro12Ala) and peroxisome proliferator-activated receptor-gamma coactivator-1 (Gly482Ser) and the response to pioglitazone in Chinese patients with type 2 diabetes mellitus.
|
20045142 |
2010 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic studies have suggested that Gly482Ser polymorphism of the PGC-1alpha gene is associated with a higher risk of type 2 diabetes, obesity, and hypertension.
|
18614852 |
2008 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A widespread Gly482Ser polymorphism of PGC-1 is associated with a 1.34 genotype relative risk of Type II diabetes.
|
11793024 |
2001 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Haplotype comparison analysis indicated that CTTCGGG and CTCTGGG haplotypes with the order of PPARG rs1801282 C>G, PPARG rs3856806 C>T, PPARGC1A rs8192678 C>T, PPARGC1A rs2970847 C>T, PPARGC1A rs3736265 G>A, PPARGC1B rs7732671 G>C and PPARGC1B rs17572019 G>A polymorphisms in gene position significantly increased the risk of T2DM.
|
28418876 |
2017 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study demonstrates that the AA genotype of the Gly482Ser polymorphism in the PPARGC1 gene might be a risk factor for diabetic retinopathy in the Slovene population (Caucasians) with type 2 diabetes (odds ratio 2.7, 95% confidence interval 1.0-6.8), whereas the Pro12Ala polymorphism of the PPARgamma gene failed to confer susceptibility to diabetic retinopathy.
|
15782399 |
2005 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Using a range of Polynesian populations (Tongan, Māori, Samoan) we re-examined evidence for association between Gly482Ser with T2D and BMI as well as gout.
|
27846814 |
2016 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective of this case-control study was to explore the relationship between SNPs of PGC-1alpha and type 2 diabetes in the southern Chinese population and to determine whether the common variants: Gly482Ser and Thr394Thr, in the PGC-1alpha gene have any impacts on interaction with myocyte enhancer factor (MEF) 2C.
|
18067759 |
2007 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis of data from the current and published studies supports a modest role for the Gly482Ser PPARGC1A variant in type 2 diabetes risk.
|
16435105 |
2006 |