|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A widespread Gly482Ser polymorphism of PGC-1 is associated with a 1.34 genotype relative risk of Type II diabetes.
|
11793024 |
2001 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Thr394Thr - Gly482Ser haplotype was associated with Type II diabetes (p = 0.00003).CONCLUSION/INTERPRETATION.
|
12107756 |
2002 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, we examined whether this G</span>ly482Ser polymorphism is associated with type 2 diabetes or obesity, or metabolic predictors of these diseases, in Pima Indians.
|
12606537 |
2003 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The prevalent Gly482Ser variant in PGC-1 was shown to be associated with type 2 diabetes in some but not all studies.
|
15146371 |
2004 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Gly482Ser genotype distribution in patients with type 2 diabetes</span> (AA = 11.5%, AG = 42.3%, GG = 46.2%) differed from genotype distribution in non-diabetic controls (AA = 6.3%, AG = 46.3%, GG = 47.5%), and the AA genotype was associated with 1.9-times increased risk of type 2 diabetes (95% confidence interval 1.0-3.6; P = 0.036).
|
15581067 |
2004 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial.
|
15592662 |
2004 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here, we assessed the association between the Gly482Ser variant of PPARGC1 and the arterial hypertension frequently found in subjects with type 2 diabetes.
|
15599700 |
2004 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies suggested linkage between the chromosomal region of PGC-1alpha and fasting serum insulin levels, and associates a Gly482Ser polymorphism of the gene with type 2 diabetes and hypertension.
|
15649578 |
2005 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study demonstrates that the AA genotype of the Gly482Ser polymorphism in the PPARGC1 gene might be a risk factor for diabetic retinopathy in the Slovene population (Caucasians) with type 2 diabetes (odds ratio 2.7, 95% confidence interval 1.0-6.8), whereas the Pro12Ala polymorphism of the PPARgamma gene failed to confer susceptibility to diabetic retinopathy.
|
15782399 |
2005 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There were no associations of the G482S and +1302G>A polymorphisms and haplotype combinations with essential hypertension and type 2 diabetes.
|
15824463 |
2004 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective of the present investigation was to examine the relationship of three polymorphisms, Thr394Thr, Gly482Ser and +A2962G, of the peroxisome proliferator activated receptor-gamma co-activator-1 alpha (PGC-1alpha) gene with Type 2 diabetes in Asian Indians.
|
16241916 |
2005 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis of data from the current and published studies supports a modest role for the Gly482Ser PPARGC1A variant in type 2 diabetes risk.
|
16435105 |
2006 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The variant allele of the Gly482Ser polymorphism in peroxisome proliferator-activated receptor-gamma co-activator-1alpha (PPARGC1A or PGC1alpha), a critical determinant of skeletal muscle metabolism, has been associated with obesity and type 2 diabetes.
|
16474966 |
2006 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Ser/X genotype of the Gly482Ser polymorphism in the PPARGC1 gene appears to be a risk factor for T2DM in northern Chinese men.
|
16978372 |
2006 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective of this case-control study was to explore the relationship between SNPs of PGC-1alpha and type 2 diabetes in the southern Chinese population and to determine whether the common variants: Gly482Ser and Thr394Thr, in the PGC-1alpha gene have any impacts on interaction with myocyte enhancer factor (MEF) 2C.
|
18067759 |
2007 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We therefore investigated if PPARGC1A expression is altered in islets from patients with type 2 diabetes and whether this expression is influenced by genetic (PPARGC1A Gly482Ser polymorphism) and epigenetic (DNA methylation) factors.
|
18270681 |
2008 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic studies have suggested that Gly482Ser polymorphism of the PGC-1alpha gene is associated with a higher risk of type 2 diabetes, obesity, and hypertension.
|
18614852 |
2008 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Together, these results showed that PPARG Pro12Ala and PPARGC1A Gly482Ser variants are associated, alone and in interaction, with insulin and glucose homeostasis and suggest that gene-gene interactions should be taken into account in candidate gene studies of T2DM to identify subjects with markedly different risks of developing the disease.
|
19536736 |
2009 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this series, there was no association between G482S polymorphism and T2DM and obesity (body mass index >25 kg/m(2)).
|
19913841 |
2010 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Common polymorphisms of the peroxisome proliferator-activated receptor-gamma (Pro12Ala) and peroxisome proliferator-activated receptor-gamma coactivator-1 (Gly482Ser) and the response to pioglitazone in Chinese patients with type 2 diabetes mellitus.
|
20045142 |
2010 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These data suggest that the PGC-1α Thr394Thr and Gly482Ser polymorphisms are associated with therapeutic efficacy of multiple-dose rosiglitazone in Chinese patients with type 2 diabetes mellitus.
|
20498286 |
2010 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that Gly482Ser and Thr394Thr polymorphisms of PPARGC1A gene were significantly associated with the risk of T2DM, especially in the Indian population.
|
21294239 |
2011 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Under an additive genetic model, the C allele of ADRB3-rs4994, the C allele of ENPP1-rs1044498, and the A allele of PPARGC1A-rs8192678 increase the risk of type 2 diabetes in the Chinese Han population.
|
22391941 |
2012 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus.
|
22684233 |
2012 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings revealed significant associations between PGC-1alpha Gly482Ser and Thr528Thr polymorphisms and type 2 diabetes in Kurdish-Iranians.
|
25282005 |
2015 |