rs10498210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IRS1- rs10498210 G/A and CCR5-59029 A/G polymorphisms in patients with type 2 diabetes in Kurdistan.
|
30884193 |
2019 |
rs13431554
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of rs13431554 in the IRS-1 gene was associated with a hyperreactive platelet phenotype in the CAD patients with T2DM.
|
27005817 |
2016 |
rs1801118
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the prevalence of each of these polymorphisms was not statistically different between NIDDM and control subjects, the prevalence of the four IRS-1 polymorphisms with an amino acid substitution together was significantly higher in NIDDM than in control subjects (23.4 vs 8.5%, p < 0.05), and two substitutions (Met 209 --> Thr and Ser809 --> Phe) were found only in NIDDM patients.
|
8739921 |
1996 |
rs1801120
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the prevalence of each of these polymorphisms was not statistically different between NIDDM and control subjects, the prevalence of the four IRS-1 polymorphisms with an amino acid substitution together was significantly higher in NIDDM than in control subjects (23.4 vs 8.5%, p < 0.05), and two substitutions (Met 209 --> Thr and Ser809 --> Phe) were found only in NIDDM patients.
|
8739921 |
1996 |
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The IRS1 gene variants Gly972Arg and Ala513Pro are not associated with type 2 diabetes in this south Indian population.
|
21612394 |
2011 |
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Insulin resistance and glucose dysmetabolism in polycystic ovary syndrome (PCOS) are related with the polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, especially Gly972Arg/Ala513Pro polymorphism being reported to be associated with type-2 diabetes and PCOS.
|
16603055 |
2006 |
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Five variant sequences of IRS-1 were identified with the NIDDM subjects; 2 silent polymorphisms at codons 235 (GGG to GGA) and 893 (CCG to CCC): 2 non-conservative mutations (Ala513Pro; Gly972Arg) and a codon deletion (Ser681-7 to Ser681-6).
|
8641117 |
1996 |
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Two mutations of the IRS-1 gene (Gly(972)Arg and Ala(513)Pro) have been described, although their roles in the development of insulin resistance and non-insulin-dependent diabetes mellitus (NIDDM) remain controversial.
|
9162610 |
1996 |
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The purpose of this study was to examine the role of the IRS-1 missense mutations at codons 972 (glycine to arginine) and 513 (alanine to proline) in two diverse populations from South India and Finland at high risk for NIDDM.
|
7796990 |
1995 |
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We studied a simple tandem repeat DNA polymorphism in the glycogen synthase gene and polymorphisms at codon 513 (Ala-->Pro) and 972 (Gly-->Arg) in the insulin receptor substrate-1 (IRS-1) gene in 197 non-insulin-dependent diabetes mellitus (NIDDM) and 178 control subjects in Japan.
|
8037748 |
1994 |
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results showed a significant difference in the genotype distribution and allele frequency between the T2DM cases and controls for single nucleotide polymorphism (SNP) rs1801278 (OR 17.61, 95% CI 8.06-38.4, p < 0.001).
|
31446532 |
2019 |
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In all, though further studies are needed for confirming this finding, our present data point to IRS1 rs1801278 as a potential biomarker for pursuing the goal of stratified medicine in the field of antihyperglycemic treatment in T2D.
|
28696414 |
2018 |
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that rs1801278 may play a role in type 2 diabetes risk, especially in Asian.
|
26582067 |
2016 |
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We failed to find any association between the IRS1 Gly972Arg polymorphism and T2DM.
|
26620983 |
2015 |
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We replicated the significant association of rs1801278 and rs3792267 SNPs of the IRS1 and CAPN10 genes with T2DM in the population of Hyderabad.
|
24612564 |
2014 |
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study confirms in a large and ethnically homogeneous sample that IRS1 G972R polymorphism is associated with failure to OAD among patients with T2D.
|
24947357 |
2014 |
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The PPARG Pro12 is associated with insulin resistance and this polymorphism interacts with IRS1 Gly972Arg, to increase the risk of T2DM in the mixed-ancestry population of South Africa.
|
24447396 |
2014 |
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, both the (rs1801278 and rs2943641) polymorphisms are associated with T2DM in the Saudi population.
|
24493031 |
2014 |
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The IRS1 G972R polymorphism and glomerular filtration rate in patients with type 2 diabetes of European ancestry.
|
24071662 |
2013 |
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings revealed that IRS-1 Gly972Arg and IRS-2 Gly1057Asp polymorphisms are associated with T2DM in the Kurdish ethnic group.
|
22994406 |
2012 |
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gene, and the G972R polymorphism of the IRS1 gene, seem to predispose to GDM in Greek women.
|
20540670 |
2011 |
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The IRS1 gene variants Gly972Arg and Ala513Pro are not associated with type 2 diabetes in this south Indian population.
|
21612394 |
2011 |
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Heterozygosity for the Gly972Arg variant of the IRS1 gene showed the strongest association for T2D in both analyzed samples (OR = 2.43, 95% CI 1.12-5.26 and 2.64, 95% CI 1.37-5.10, respectively).
|
21834909 |
2011 |
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of Gly972Arg polymorphism of IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study.
|
19716569 |
2010 |
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this Review, we discuss the role of relatively infrequent polymorphisms of genes that regulate insulin signaling (including the K121Q polymorphism of ENPP1, the G972R polymorphism of IRS1 and the Q84R polymorphism of TRIB3) in T2DM and other conditions related to insulin resistance.
|
19924153 |
2009 |