|
rs104893642
|
|
C |
0.710 |
CausalMutation |
CLINVAR |
|
|
|
|
rs104893642
|
|
|
0.710 |
GeneticVariation |
BEFREE |
A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.
|
12679424 |
2003 |
|
rs1259467443
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicate that the IRS-1 Gly972Arg variant does not substantially increase risk of common Type 2 diabetes, or Type 2 diabetes in obese persons.
|
15209769 |
2004 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this Review, we discuss the role of relatively infrequent polymorphisms of genes that regulate insulin signaling (including the K121Q polymorphism of ENPP1, the G972R polymorphism of IRS1 and the Q84R polymorphism of TRIB3) in T2DM and other conditions related to insulin resistance.
|
19924153 |
2009 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the Gly9</span>72Arg polymorphism does not play an important role in the pathogenesis of NIDDM in Japanese patients.
|
7673430 |
1995 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These alterations may account for the increased predisposition to type 2 diabetes in individuals carrying the Gly(972)-->Arg amino acid polymorphism of IRS-1.
|
11978638 |
2002 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of Gly972Arg polymorphism of IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study.
|
19716569 |
2010 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G>A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland.
|
17570749 |
2005 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied a simple tandem repeat DNA polymorphism in the glycogen synthase gene and polymorphisms at codon 513 (Ala-->Pro) and 972 (Gly-->Arg) in the insulin receptor substrate-1 (IRS-1) gene in 197 non-insulin-dependent diabetes mellitus (NIDDM) and 178 control subjects in Japan.
|
8037748 |
1994 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In all, though further studies are needed for confirming this finding, our present data point to IRS1 rs1801278 as a potential biomarker for pursuing the goal of stratified medicine in the field of antihyperglycemic treatment in T2D.
|
28696414 |
2018 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Five variant sequences of IRS-1 were identified with the NIDDM subjects; 2 silent polymorphisms at codons 235 (GGG to GGA) and 893 (CCG to CCC): 2 non-conservative mutations (Ala513Pro; Gly972Arg) and a codon deletion (Ser681-7 to Ser681-6).
|
8641117 |
1996 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The IRS1 G972R polymorphism and glomerular filtration rate in patients with type 2 diabetes of European ancestry.
|
24071662 |
2013 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We replicated the significant association of rs1801278 and rs3792267 SNPs of the IRS1 and CAPN10 genes with T2DM in the population of Hyderabad.
|
24612564 |
2014 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Gly971Arg, is more common in Mexican Americans and Caucasians, but is not a major contributor to genetic susceptibility to Type 2 diabetes.
|
11025561 |
2000 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, IRS-1 (Gly(972)Arg) and IRS-2 (Gly(1057)Asp), influence susceptibility to type 2 diabetes.
|
12213887 |
2002 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Also, the diagnostic test to exclude diabetes amongst control subjects interacted with the association between the IRS-1 Gly972Arg variant and Type 2 diabetes (p=0.03).
|
12819898 |
2003 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
From statistical analysis carried out here, individually, the Pst I, Nsi I and Gly972Arg polymorphisms were not associated with the type 2 diabetes, obese or hypertensive phenotypes in this population.
|
15581831 |
2005 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Amino acid polymorphism Gly 972 Arg in IRS-1 is not associated to lower clamp-derived insulin sensitivity in young healthy first degree relatives of patients with type 2 diabetes.
|
10482045 |
1999 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings revealed that IRS-1 Gly972Arg and IRS-2 Gly1057Asp polymorphisms are associated with T2DM in the Kurdish ethnic group.
|
22994406 |
2012 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have genotyped three single nucleotide polymorphisms associated with type 2 diabetes in a large type 1 diabetic family collection of European descent: Gly972Arg in the insulin receptor substrate 1 (IRS1) gene, Glu23Lys in the potassium inwardly-rectifying channel gene (KCNJ11), and Pro12Ala in the peroxisome proliferative-activated receptor gamma2 gene (PPARG2).
|
14988278 |
2004 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IRS1 G972R polymorphism and type 2 diabetes: a paradigm for the difficult ascertainment of the contribution to disease susceptibility of 'low-frequency-low-risk' variants.
|
19557384 |
2009 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The most commonly detected polymorphism in human insulin receptor substrate-1 (IRS-1), a glycine to arginine change at codon 972 (G972R), is associated with an increased risk of Type 2 diabetes and insulin resistance.
|
15590636 |
2005 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study confirms in a large and ethnically homogeneous sample that IRS1 G972R polymorphism is associated with failure to OAD among patients with T2D.
|
24947357 |
2014 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, cerebrocortical insulin resistance is found in individuals with the Gly972Arg polymorphism in IRS-1, which is considered a type 2 diabetes risk gene.
|
16877540 |
2006 |