|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In a population-based cohort of elderly men with well-defined phenotypes and biochemical markers related to type 2 diabetes mellitus, we analysed two single nucleotide polymorphisms (SNPs), rs7903146 and rs12255372, in the transcription factor 7-like 2 gene (TCF7L2), which are associated with an increased risk of type 2 diabetes mellitus.
|
17618413 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The four tested TCF7L2 variants were in linkage disequilibrium, and 4-locus (rs4506565, rs7903146, rs12243326, rs12255372) haplotype analysis demonstrated that haplotype 1111 was negatively associated (Pc<0.001), while haplotypes 2222 (Pc=0.008) and 2211 (Pc=0.020) were positively associated with T2DM risk, after controlling for a number of covariates.
|
23142382 |
2013 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, the T allele of the rs12255372(G/T) and rs7903146(C/T) polymorphisms of TCF7L2 gene confer susceptibility to type 2 diabetes mellitus in Asian Indians.
|
17697858 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Individuals homozygous for rs7903146 and rs12255372</span> T2D risk alleles (TT/TT) expressed 2.6-fold greater levels of TCF7L2 mRNA compared to individuals homozygous for the non-risk alleles (CC/GG, p = 0.006), although differentially spliced TCF7L2 transcripts did not differ by T2D risk-associated genotype.
|
22402060 |
2013 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans.
|
19184112 |
2009 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Haplotype analysis (rs7901695-rs4506565-rs7903146-rs12243326-rs7895340-rs11196205-rs12255372) identified positively- (2122112, 2222222) and negatively- (1111111) T2DM-associated haplotypes.
|
23107111 |
2012 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
No association was found for rs12255372, rs3814573, c.1,637C>A and type 2 diabetes (p = 0.278-1.000).
|
18493736 |
2008 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
An interaction (p = 0.048) between TCF7L2 variants and coffee intake was apparent, with an inverse association between coffee and type 2 diabetes present among carriers of the diabetes risk allele (T) in rs12255372 (GG: HR 0.99 [95% CI 0.97, 1.02] per cup of coffee; GT: HR 0.96 [95% CI 0.93, 0.98]); and TT: HR 0.93 [95% CI 0.88, 0.98]).
|
27623947 |
2016 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.
|
17668382 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Results of our analyses strongly confirmed the minor T alleles as risk variants for type 2 diabetes (rs7903146: OR (TvsC) [95% CI]=1.36 [1.18;1.58], p=0.00003, and rs12255372: OR (TvsG) [95% CI]=1.31 [1.13;1.51], p=0.0003).
|
17226113 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
GWASDB |
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
|
17460697 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The T-allele of the SNP rs12255372 of TCF7L2 (OR = 2.70, 95% CI = 1.12-6.49, P = 0.027) and the A-allele of PDX-1 D76N (OR = 3.93, 95% CI = 1.60-7.68, P = 0.002) were significantly associated with an increased risk of T2DM.
|
26058934 |
2015 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found that SNPs rs7901695, rs4506565, rs7903146 and rs12255372 in the TCF7L2 gene were strongly associated with T2D (p<0.004).
|
19053027 |
2009 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We genotyped the TCF7L2 single nucleotide polymorphisms rs7903146 and rs12255372 (previously associated with type 2 diabetes) and rs10885406 and rs7924080 (which tag haplotype A [HapA], a haplotype reported to be associated with obesity) in 2,512 FHS participants.
|
19183934 |
2009 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The variant of rs12255372 of TCF7L2 was associated with incident type 2 diabetes in the DPS and in a separate population-based cross-sectional study.
|
17437080 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We observed a significant association between the single-nucleotide polymorphism (SNP) rs12255372 and the microsatellite DG10S478 with T2D in the Mexican sample [rs12255372, odds ratio (OR) = 1.78, p = 0.017; DG10S478, OR = 1.62, p = 0.041].
|
17470138 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These findings suggest that the TCF7L2 rs12255372 (G>T) polymorphism might be one of the most important genetic factors associated with T2DM susceptibility, and that individuals in the Chinese Hui population who carry a G allele at this locus might be at risk to develop T2DM.
|
26345943 |
2015 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The meta-analysis results demonstrated that TCF7L2 rs4506565, rs7901695, rs11196205 and rs12255372 polymorphisms were all significantly associated with susceptibility to T2DM in general population.
|
31288068 |
2020 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The risk alleles of the TCF7L2 gene (rs12255372 and rs7903146) were strongly associated with type 2 diabetes, even after controlling for traditional risk factors in both a cross-sectional and prospective setting.
|
18972257 |
2009 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Adjusting also for T2D-related covariates, body mass index (BMI), and ancestry did not change the results substantively (rs7901695, p = 0.003; rs7903146, p = 0.005; rs11196205, p = 0.001; and rs12255372, p = 0.005).
|
31676834 |
2019 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The minor alleles of rs7903146, rs11196205, and rs12255372 showed significant associations with type 2 diabetes (OR=1.48, P=2.7 x 10(-4); OR=1.39, P=4.6 x 10(-4); OR=1.70, P=9.8 x 10(-5), respectively) in the combined sample sets.
|
18097733 |
2008 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Perform the meta-analysis of all the validated studies and evaluate the association between rs7903146 T allele, rs12255372 T allele, rs11196205 C allele, rs290487 C allele and rs11196218 G allele of TCF7L2 and the risk of T2DM.
|
19482368 |
2009 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We compared genotype frequencies in subjects with type 2 diabetes with those with NGT and found marginal association for rs7901695 (P = 0.05; odds ratio [OR] 1.51); comparison between NGT control subjects and the combined type 2 diabetes/IGT case group showed strong association with rs7901695 and rs7903146 (P = 0.008-0.01; OR 1.53-1.57) and marginal association with rs11196205 and rs12255372 (P = 0.07 and P = 0.04, respectively).
|
16936218 |
2006 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In our case-control subjects, susceptibility to type 2 diabetes was replicated in TCF7L2 (rs12255372), CDKAL1 (rs7756992, rs7754840), HHEX (rs7923837), IGF2BP2 (rs4402960 and rs1470579), CDKN2A/B (rs10811661), and SLC30A8 (rs13266634).
|
19033397 |
2009 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Expression of TCF7L2 alternatively spliced forms may have different functional roles in omental and subcutaneous adipose tissue but is not associated with SNPs rs7903146 and rs12255372 or T2D status.
|
19789636 |
2009 |