|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In a population-based cohort of elderly men with well-defined phenotypes and biochemical markers related to type 2 diabetes mellitus, we analysed two single nucleotide polymorphisms (SNPs), rs7903146 and rs12255372, in the transcription factor 7-like 2 gene (TCF7L2), which are associated with an increased risk of type 2 diabetes mellitus.
|
17618413 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, the T allele of the rs12255372(G/T) and rs7903146(C/T) polymorphisms of TCF7L2 gene confer susceptibility to type 2 diabetes mellitus in Asian Indians.
|
17697858 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.
|
17668382 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Results of our analyses strongly confirmed the minor T alleles as risk variants for type 2 diabetes (rs7903146: OR (TvsC) [95% CI]=1.36 [1.18;1.58], p=0.00003, and rs12255372: OR (TvsG) [95% CI]=1.31 [1.13;1.51], p=0.0003).
|
17226113 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
GWASDB |
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
|
17460697 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The variant of rs12255372 of TCF7L2 was associated with incident type 2 diabetes in the DPS and in a separate population-based cross-sectional study.
|
17437080 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We observed a significant association between the single-nucleotide polymorphism (SNP) rs12255372 and the microsatellite DG10S478 with T2D in the Mexican sample [rs12255372, odds ratio (OR) = 1.78, p = 0.017; DG10S478, OR = 1.62, p = 0.041].
|
17470138 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies novel risk loci for type 2 diabetes.
|
17293876 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We genotyped 6,516 participants for rs12255372 and rs7903146 and analysed the role in type 2 diabetes susceptibility using binary logistic regression.
|
17429603 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rest of the five SNPs (rs7895340, rs11196205 and rs12255372) did not show any significant associations with type 2 diabetes.
|
17245589 |
2007 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently, the transcription factor 7-like 2 (TCF7L2) gene on chromosome 10q25.2 has been linked with type 2 diabetes among Caucasians, with disease associations noted for single nucleotide polymorphisms (SNPs) rs12255372 and rs7903146.
|
17130514 |
2006 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A total of 2,676 healthy European white middle-aged men from the prospective NPHSII (158 developed T2D over 15 years surveillance) were genotyped for two intronic SNPs [rs 7903146 (IVS3C>T) and rs12255372 (IVS4G>T)] which showed strong linkage disequilibrium (D' = 0.88, p<0.001; R(2)=0.76, p<0.001).
|
17665514 |
2006 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In a prospective, nested, case-control study (n = 3,520) within the Nurses' Health Study (687 type 2 diabetic case and 1,051 control subjects) and the Health Professionals Follow-up Study (886 case and 896 control subjects), we examined the association of a common variant of the TCF7L2 gene (rs12255372 [T/G]) with type 2 diabetes risk among Caucasians.
|
16936216 |
2006 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We compared genotype frequencies in subjects with type 2 diabetes with those with NGT and found marginal association for rs7901695 (P = 0.05; odds ratio [OR] 1.51); comparison between NGT control subjects and the combined type 2 diabetes/IGT case group showed strong association with rs7901695 and rs7903146 (P = 0.008-0.01; OR 1.53-1.57) and marginal association with rs11196205 and rs12255372 (P = 0.07 and P = 0.04, respectively).
|
16936218 |
2006 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Both the T-allele of rs7903146 and the T-allele of rs12255372 significantly increase type 2 diabetes risk with an allelic odds ratio (OR) of 1.69 (95% CI 1.55-1.83) (P = 6.0 x 10(-35)) and 1.60 (1.47-1.74) (P = 7.6 x 10(-28)), respectively.
|
17003360 |
2006 |
|
rs12255372
|
|
T |
0.900 |
SusceptibilityMutation |
CLINVAR |
|
|
|