|
rs564398
|
|
|
0.810 |
GeneticVariation |
BEFREE |
To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609.
|
22377712 |
2012 |
|
rs564398
|
|
T |
0.810 |
GeneticVariation |
GWASCAT |
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
|
17463249 |
2007 |
|
rs564398
|
|
T |
0.810 |
GeneticVariation |
GWASDB |
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
|
17463249 |
2007 |
|
rs944801
|
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
rs944801
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
rs1063192
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |
|
rs10757274
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Out of the eight studied SNPs, two, rs10757274_A [0.915 (0.840-1.00); p = 0.042], rs1333045_T [0.92(0.84-1.00); p = 0.048] were initially associated with type 2 diabetes but lost the association after multivariate adjustments for CAD, hypertension and MI, while rs10757274_A showed borderline association with hypertension.
|
30510472 |
2018 |
|
rs2383206
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The major objectives of this study were to examine the association of rs10757278 and rs2383206 SNPs on Chr9p21 with the incidence of CAD in the presence and absence of type 2 diabetes (T2D) in Egyptians and to correlate these genetic variants with several disease biomarkers (TC, CRP, and HbA1c).
|
28559532 |
2017 |
|
rs10757274
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Furthermore, T2DM is likely to have an interaction with CDKN2A/B (rs10757274) that contributes to the risk of MI.
|
25430018 |
2014 |
|
rs2383206
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We also aimed to replicate the previously observed interaction between rs2383206 and glycemic control on mortality.Genotypes for three SNPs were determined in 914 individuals from a prospective cohort of T2D patients of Dutch origin.
|
23134948 |
2012 |
|
rs2383206
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We investigated whether the coronary artery disease (CAD) locus on chromosome 9p21 (as represented by single nucleotide polymorphism rs2383206) is associated with low estimated glomerular filtration rate (eGFR) or increased urinary albumin excretion in patients with Type 2 diabetes mellitus (T2DM).
|
22622453 |
2012 |
|
rs10757274
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Two CAD- and aneurysm-associated SNPs (rs10757274 and rs2891168) and one T2D-associated SNP (rs1081161) within the 9p21.3 region were genotyped.
|
19019192 |
2009 |
|
rs10757278
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The major objectives of this study were to examine the association of rs10757278 and rs2383206 SNPs on Chr9p21 with the incidence of CAD in the presence and absence of type 2 diabetes (T2D) in Egyptians and to correlate these genetic variants with several disease biomarkers (TC, CRP, and HbA1c).
|
28559532 |
2017 |
|
rs1333049
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The majority of the potentially novel results were for single PheWAS phenotype-classes, for example, for CDKN2A/B rs1333049 (previously associated with type 2 diabetes in EA) a PheWAS association was identified for hemoglobin levels in AA.
|
23382687 |
2013 |
|
rs1333049
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study aimed to examine the association of variant rs1333049 on chromosome 9p21.3 with early-onset and severity of CAD in Chinese patients with and without type 2 diabetes, and to determine the possible impact of rs1333049 on glucose metabolism and inflammation pathways.
|
21362310 |
2011 |
|
rs2891168
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our replication study showed that rs2891168 and rs10811661 are independently associated respectively with MI and T2D in an Italian population.
|
20403154 |
2010 |
|
rs2891168
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Two CAD- and aneurysm-associated SNPs (rs10757274 and rs2891168) and one T2D-associated SNP (rs1081161) within the 9p21.3 region were genotyped.
|
19019192 |
2009 |
|
rs10757278
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) = 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D.
|
18176561 |
2008 |
|
rs1333045
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Out of the eight studied SNPs, two, rs10757274_A [0.915 (0.840-1.00); p = 0.042], rs1333045_T [0.92(0.84-1.00); p = 0.048] were initially associated with type 2 diabetes but lost the association after multivariate adjustments for CAD, hypertension and MI, while rs10757274_A showed borderline association with hypertension.
|
30510472 |
2018 |
|
rs10738610
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further investigation showed that rs10738610 (P < 1.99×10(-2)) was found to be significantly associated with severity of CAD in subjects with T2D.
|
23343465 |
2013 |
|
rs2383207
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified two 9p21.3-variants, rs4977574 (P < 4×10(-4)) and rs2383207 (P < 1.5×10(-3)) that were associated with severity of CAD in subjects without T2D.
|
23343465 |
2013 |
|
rs4977574
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified two 9p21.3-variants, rs4977574 (P < 4×10(-4)) and rs2383207 (P < 1.5×10(-3)) that were associated with severity of CAD in subjects without T2D.
|
23343465 |
2013 |
|
rs495490
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The analyses showed that age (P < 0.0001), BMI (P < 0.0001), and six variants (IGF2BP2 rs4402960, P = 0.002; ADIPOQ+276 G>T, P = 0.004; UCP2Ala55Val, P = 0.01; CDKN2AI2B rs3731201, P = 0.02; rs495490, P = 0.02, and rsl 0811661, P = 0.03) were significantly associated with the risk of IFG/IGT/T2DM.
|
20384434 |
2010 |
|
rs1412829
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the 18 polymorphisms, the ADAMTS9, CDKAL1, CDKN2A/B-rs1412829, FTO, IGF2BP2, JAZF1, SLC30A8, TCF7L2, and WFS1 variants were associated with type 2 diabetes risk in our population.
|
18694974 |
2008 |