|
rs4812829
|
|
A |
0.830 |
GeneticVariation |
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
rs4812829
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Among these nine SNPs that previously showed an association with T2DM in Asian Indians, HMG20A (rs7178572) and HNF4A (rs4812829</span>) gene variants showed a significant association with GDM.
|
28190082 |
2017 |
|
rs4812829
|
|
|
0.830 |
GeneticVariation |
BEFREE |
The aim of the current study was to analyze the effect of six type II diabetes GWAS loci rs3923113 (GRB14), rs16861329 (ST6GAL1), rs1802295 (VPS26A), rs7178572 (HMG20A), rs2028299 (AP3S2) and rs4812829 (HNF4A), and an FTO polymorphism (rs9939609) on obesity.
|
26395551 |
2016 |
|
rs4812829
|
|
A |
0.830 |
GeneticVariation |
GWASCAT |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
rs4812829
|
|
A |
0.830 |
GeneticVariation |
GWASDB |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
rs4812829
|
|
|
0.830 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
|
23300278 |
2013 |
|
rs4812829
|
|
|
0.830 |
GeneticVariation |
BEFREE |
We genotyped 11,319 Japanese participants (8,318 with type 2 diabetes and 3,001 controls) for each of the 7 SNPs-rs5945326 near DUSP9, rs3923113 near GRB14, rs16861329 in ST6GAL1, rs1802295 in VPS26A, rs7178572 in HMG20A, rs2028299 near AP3S2, and rs4812829 in HNF4A-and examined the association of each of these 7 SNPs with type 2 diabetes by using logistic regression analysis.
|
23029454 |
2012 |
|
rs4812829
|
|
A |
0.830 |
GeneticVariation |
GWASDB |
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
|
21874001 |
2011 |
|
rs4812829
|
|
A |
0.830 |
GeneticVariation |
GWASCAT |
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
|
21874001 |
2011 |
|
rs1800961
|
|
|
0.720 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs1800961
|
|
T |
0.720 |
GeneticVariation |
GWASCAT |
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
|
29632382 |
2018 |
|
rs1800961
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ11), rs1801282 (PPARγ), rs10811661 (CDKN2A/2B), rs13266634 (SLC30A8), rs12779790 (CDC123/CAMK1D), rs7903146 (TCF7L2), rs9282541 (ABCA1) and rs13342692 (SLC16A11) polymorphisms in the genetic background of Maya population to associate their susceptibility to develop T2D.
|
25839936 |
2015 |
|
rs1800961
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Three additional variants were associated with T2D: two intronic SNPs (rs4810424: OR: 1.080, 95%CI: 1.010-1.154, p<0.03 and rs3212183: OR: 0.843, 95%CI: 0.774-0.918, p<0.00009) and one missense variant (rs1800961: OR: 0.770, 95%CI: 0.595-0.995, p<0.05, 6562 cases and 6723 controls).
|
19748811 |
2010 |
|
rs16988991
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.
|
30718926 |
2019 |
|
rs6103716
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
|
31118516 |
2019 |
|
rs4810426
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |
|
rs4812831
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
|
21874001 |
2011 |
|
rs137853337
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus.
|
9449683 |
1998 |
|
rs587777732
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs2144908
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analysis showed only rs266729 and rs17300539 of ADIP</span>OQ, and rs1884613, rs2144908, and rs4810424 of HNF4A were significantly associated with T2D risk.
|
30860284 |
2019 |
|
rs2144908
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, the frequency of haplotype, CCTA, built by rs4810424, rs1884613, rs1884614 and rs2144908 was significantly higher in the type 2 diabetes mellitus group compared with the control group (χ2=8.34, P=0.004).
|
26781905 |
2016 |
|
rs2144908
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The SNPs rs4810424, rs1884613, and rs2144908 were associated with protection against type 2 diabetes without metabolic syndrome (recessive P = 0.018, OR 0.32; P = 0.004, OR 0.25; P = 0.005, OR 0.24, respectively).
|
21983932 |
2012 |
|
rs2144908
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of the minor allele of the rs2144908 was significantly higher in subjects with MODY (p < 0.01) and that of rs736823 was significantly higher in early onset T2DM (p = 0.001).
|
21062274 |
2011 |
|
rs2144908
|
|
|
0.100 |
GeneticVariation |
BEFREE |
HNF4A promoter P2 polymorphisms rs1884613 and rs2144908, which are in high linkage disequilibrium, showed significant association with type 2 diabetes (odds ratio (OR)=1.37 (95% confidence interval (CI) 1.19-1.57), P=9.4 × 10(-6) for rs1884613 and OR=1.37 (95%CI 1.20-1.57), P=6.0 × 10(-6) for rs2144908), as previously shown in other populations.
|
21814221 |
2011 |
|
rs2144908
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although no interactions between the four variants on the risk of type 2 diabetes were detected, the multiplicative interaction between PPARG Pro12Ala and HNF4A rs2144908 was found to be associated with 2-hour postprandial insulin (P = 0.004 under an additive model for rs2144908; and P = 0.001 under a dominant model for rs2144908) after adjusting for age, sex and BMI, assuming a dominant model for PPARG Pro12Ala.
|
20079163 |
2009 |