|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, Q192R polymorphism was more correlated with type 2 diabetes mellitus.
|
31102685 |
2019 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
PON1 (Q192R and L55M) polymorphisms may play a crucial role in pathogenesis and susceptibility of insulin resistance thus leads to the development of type 2 diabetes in South Indian population.
|
29409844 |
2018 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Sex should be considered a confounding variable in association studies on the variants PON1-Q192R and PON2-A148G in T2D.
|
29782842 |
2018 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
As for the PON1 Q192R polymorphism, the 192R allele was a susceptible factor of T2DM in the South or East Asian population (OR > 1, P < 0.05) but represented a protective factor of T2DM in European population (OR = 0.66, 95% CI = 0.45-0.98) under a heterozygous genetic model.
|
29314660 |
2018 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data suggest that the variant PON1-Q192R and PON1 activity, particularly PON-aryl, influenced the antioxidant status in T2D.
|
27022137 |
2016 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study will give an insight about the association of two selected candidate gene polymorphisms; paraoxonase1 (PON1) Q192R and apolipoprotein A5 (APOA5) -1131T>C were assessed in a cohort of South Indian patients having CAD with and without T2DM.
|
21438666 |
2011 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated whether the human serum paraoxonase (PON1) Q/R 192 and M/L 55 polymorphisms are associated with the complications of the type 2 diabetes (T2D).
|
21223956 |
2011 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
QR, RR (Q192R) and GC, CC (-909G/C) genotypes and L-C-A-R-G, L-T-A-R-G, L-T-G-Q-C haplotypes showed significant association with type 2 diabetes.
|
21803130 |
2011 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Serum Pon1 activities in both DM and non-DM patients on HD were regulated by Pon1 Q192R polymorphism: RR > QR > QQ.
|
14579940 |
2003 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The difference in allele frequency for the PON(1) Q/R 192 gene polymorphism may be the cause of the low paraoxonase activity observed in type 2 diabetes mellitus.
|
12442067 |
2002 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Paraoxonase 1 192 Gln/Arg gene polymorphism and cerebrovascular disease: interaction with type 2 diabetes.
|
11409295 |
2001 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
It has been hypothesized an A/B (Gln 192-->Arg) polymorphism of PON may be involved in the pathogenesis of CHD, especially among subjects with non-insulin-dependent diabetes mellitus (NIDDM).
|
8960946 |
1996 |
|
rs854560
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Paraoxonase 1 (PON1)-L55M among common variants in the coding region of the paraoxonase gene family may contribute to the glycemic control in type 2 diabetes.
|
29782842 |
2018 |
|
rs854560
|
|
|
0.060 |
GeneticVariation |
BEFREE |
PON1 (Q192R and L55M) polymorphisms may play a crucial role in pathogenesis and susceptibility of insulin resistance thus leads to the development of type 2 diabetes in South Indian population.
|
29409844 |
2018 |
|
rs854560
|
|
|
0.060 |
GeneticVariation |
BEFREE |
With regard to the PON1 L55M polymorphism, significant protective effects of the 55M allele on T2DM under the heterozygous (OR = 0.77, 95% CI = 0.61-0.97) and dominant (OR = 0.80, 95% CI = 0.65-0.99) genetic models were found in the European population, while no significant associations in the Asian populations under all genetic models (P > 0.05).
|
29314660 |
2018 |
|
rs854560
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The rs854560 in PON1 was associated with incidences of T2D and increased the risk of cardiovascular complications [P=0.031, OR 0.663 (95% CI 0.455-0.965)] in diabetics.
|
24477584 |
2014 |
|
rs854560
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We investigated whether the human serum paraoxonase (PON1) Q/R 192 and M/L 55 polymorphisms are associated with the complications of the type 2 diabetes (T2D).
|
21223956 |
2011 |
|
rs854560
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Association between M/L55-polymorphism of paraoxonase enzyme and oxidative DNA damage in patients with type 2 diabetes mellitus and in control subjects.
|
10480377 |
1999 |
|
rs13306698
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariable logistic regression analysis with adjustment for age, body mass index, and smoking status revealed that the T-->G (3' UTR) polymorphism of the thrombospondin 2 gene (THBS2), the -603A-->G polymorphism of the coagulation factor III gene (F3), and the G-->T (intron 2) polymorphism of the adipocyte, C1Q, and collagen domain containing (adiponectin) gene (ADIPOQ) were significantly associated with the prevalence of type 2 diabetes mellitus in men, and that the A-->G (Arg160Gly) polymorphism of the paraoxonase 1 gene (PON1) was significantly associated with this condition in women.
|
17334638 |
2007 |