Gene: ABCC8 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs757110
rs757110
ABCC8
C 0.790 GeneticVariation GWASCAT Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes. 29358691

2018
dbSNP: rs757110
rs757110
ABCC8
0.790 GeneticVariation BEFREE We found rs5219 and rs757110 were not associated with T2DM in this population, and that there was linkage disequilibrium in Siberians (D'=0.766, r(2)= 0.5633). 25955821

2015
dbSNP: rs757110
rs757110
ABCC8
0.790 GeneticVariation BEFREE We performed a comprehensive meta-analysis for KCNJ11 rs5219, rs5210, rs5215, and ABCC8 rs757110 to evaluate the effect of these regions on genetic susceptibility for type 2 diabetes. 24065655

2013
dbSNP: rs757110
rs757110
ABCC8
0.790 GeneticVariation BEFREE The ATP-sensitive K(+) channel ABCC8 S1369A type 2 diabetes risk variant increases MgATPase activity. 22187380

2012
dbSNP: rs757110
rs757110
ABCC8
0.790 GeneticVariation BEFREE Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A. 22209866

2012
dbSNP: rs757110
rs757110
ABCC8
0.790 GeneticVariation BEFREE Comprehensive tagging studies have demonstrated that the KCNJ11 E23K variant (or ABCC8 A1369S in LD>0.9) is responsible for the known association between KCNJ11 and T2D. 17342155

2007
dbSNP: rs757110
rs757110
ABCC8
0.790 GeneticVariation BEFREE We found significant associations between eight SNPs, including the KCNJ11 E23K and ABCC8 S1369A variants, and T2D. 17823772

2007
dbSNP: rs757110
rs757110
ABCC8
0.790 GeneticVariation BEFREE Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program. 17259403

2007
dbSNP: rs757110
rs757110
ABCC8
0.790 GeneticVariation BEFREE The Asp673Asn variant in exon 14 was only identified in one NIDDM patient, and the allelic frequency of the Ser1369Ala was similar among 247 control subjects (0.38 [95% CI 0.34-0.42]) and 406 NIDDM patients (0.40 [0.37-0.43]). 9568693

1998
dbSNP: rs757110
rs757110
ABCC8
0.790 GeneticVariation BEFREE Pairwise allelic associations indicated significant linkage disequilibrium between the variants in Kir6.2 and between them and a nearby pancreatic beta-cell sulfonylurea receptor (SUR1) missense variant (S1370A), but these linkage disequilibria did not differ between the NIDDM and control groups. 9032109

1997
dbSNP: rs137852673
rs137852673
ABCC8
A 0.700 CausalMutation CLINVAR

dbSNP: rs137852674
rs137852674
ABCC8
C 0.700 CausalMutation CLINVAR

dbSNP: rs1554948310
rs1554948310
ABCC8
G 0.700 GeneticVariation CLINVAR

dbSNP: rs193922402
rs193922402
ABCC8
A 0.700 GeneticVariation CLINVAR

dbSNP: rs72559715
rs72559715
ABCC8
T 0.700 GeneticVariation CLINVAR

dbSNP: rs72559722
rs72559722
ABCC8
A 0.700 CausalMutation CLINVAR

dbSNP: rs72559734
rs72559734
ABCC8
T 0.700 CausalMutation CLINVAR

dbSNP: rs1272388614
rs1272388614
ABCC8
0.010 GeneticVariation BEFREE R1420H carriers had higher mean birth weights and a twofold increased risk for type 2 diabetes with a 7-year earlier onset age despite being leaner than noncarriers. 26246406

2015
dbSNP: rs1799854
rs1799854
ABCC8
0.010 GeneticVariation BEFREE The exon 16 -3c/t variant rs1799854 in ABCC8 showed a significant association (P = 0.0073), and variants in several genes showed nominally significant associations (P < 0.05) with type 2 diabetes. 16873704

2006
dbSNP: rs777986828
rs777986828
ABCC8
0.010 GeneticVariation BEFREE The Asp673Asn variant in exon 14 was only identified in one NIDDM patient, and the allelic frequency of the Ser1369Ala was similar among 247 control subjects (0.38 [95% CI 0.34-0.42]) and 406 NIDDM patients (0.40 [0.37-0.43]). 9568693

1998