Gene: IAPP ×
Source: BEFREE ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1466929132
rs1466929132
IAPP ; SLCO1A2
0.050 GeneticVariation BEFREE Further in vivo zebrafish embryonic assay indicated improved survival and hatching, as well as decreased frequency and severity of developmental abnormalities for embryos treated with the heteroaggregates of IAPP with 19-29 S20G, but not with 8-20, compared to the control, indicating the therapeutic potential of 19-29 S20G against T2D. 31455083

2019
dbSNP: rs1466929132
rs1466929132
IAPP ; SLCO1A2
0.050 GeneticVariation BEFREE A missense mutation in amylin at amino acid 20 from Serine to Glycine (S20G) has been shown to be associated with type 2 diabetes. 12706321

2003
dbSNP: rs1466929132
rs1466929132
IAPP ; SLCO1A2
0.050 GeneticVariation BEFREE These data suggest that the S20G mutation in the amylin gene is associated with increased risk of development of Type II diabetes in Japanese. 11508277

2001
dbSNP: rs1466929132
rs1466929132
IAPP ; SLCO1A2
0.050 GeneticVariation BEFREE The islet amyloid polypeptide (amylin) gene S20G mutation in Chinese subjects: evidence for associations with type 2 diabetes and cholesterol levels. 11318791

2001
dbSNP: rs1466929132
rs1466929132
IAPP ; SLCO1A2
0.050 GeneticVariation BEFREE These findings suggest that the S20G mutation of the amylin gene may play a partial role in the pathogenesis of early-onset NIDDM in the Japanese population and may also provide an important model to investigate the true physiological action of amylin. 8772735

1996