rs137852783
|
|
|
0.760 |
GeneticVariation |
BEFREE |
The T-allele of the SNP rs12255372 of TCF7L2 (OR = 2.70, 95% CI = 1.12-6.49, P = 0.027) and the A-allele of PDX-1 D76N (OR = 3.93, 95% CI = 1.60-7.68, P = 0.002) were significantly associated with an increased risk of T2DM.
|
26058934 |
2015 |
rs137852783
|
|
|
0.760 |
GeneticVariation |
BEFREE |
So far, this is the largest association study regarding the effect of D76N IPF1 on T2D.
|
17592437 |
2007 |
rs137852783
|
|
|
0.760 |
GeneticVariation |
BEFREE |
The D76N variant of PDX1 does not significantly alter insulin secretion or act as a high-risk susceptibility allele for late-onset type 2 diabetes as proposed previously, although we cannot exclude a minor role in increasing risk of diabetes.
|
15277425 |
2004 |
rs137852783
|
|
|
0.760 |
GeneticVariation |
BEFREE |
We genotyped U.S. Caucasians with (n = 217) and without (n = 176) Type 2 diabetes to determine if three previously identified variants (Cys18Arg, Asp76Asn, Arg197His) in the IPF-1 gene play a role in the development of Type 2 diabetes.
|
11914043 |
2002 |
rs137852783
|
|
|
0.760 |
GeneticVariation |
BEFREE |
The D76N variant was found in one MODY3 family (S315fsinsA of HNF1alpha) and also in two families with late-onset Type II diabetes.
|
11270685 |
2001 |
rs137852783
|
|
|
0.760 |
GeneticVariation |
BEFREE |
In the patients with late-onset type 2 diabetes we identified a noncoding G insertion/deletion polymorphism at nucleotide -108, a silent G54G, and a rare missense D76N variant.
|
10720084 |
2000 |
rs137852786
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We genotyped U.S. Caucasians with (n = 217) and without (n = 176) Type 2 diabetes to determine if three previously identified variants (Cys18Arg, Asp76Asn, Arg197His) in the IPF-1 gene play a role in the development of Type 2 diabetes.
|
11914043 |
2002 |
rs137852786
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Three novel IPF-1 missense mutations (C18R, D76N, and R197H) were identified in patients with type 2 diabetes.
|
10545530 |
1999 |
rs137852785
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We genotyped U.S. Caucasians with (n = 217) and without (n = 176) Type 2 diabetes to determine if three previously identified variants (Cys18Arg, Asp76Asn, Arg197His) in the IPF-1 gene play a role in the development of Type 2 diabetes.
|
11914043 |
2002 |
rs137852787
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The E224K mutation cosegregated with early-onset diabetes or impaired glucose tolerance in a large family, suggestive of the type 4 form of maturity-onset diabetes of the young rather than type 2 diabetes.
|
14764823 |
2004 |
rs199644078
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The P239Q variant was identified in two families with early-onset diabetes including one with MODY3 (R272C of HNF1alpha) and in three families with late-onset Type II diabetes.
|
11270685 |
2001 |