|
rs699947
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The VEGF gene SNPs analyzed with regard to DR susceptibility were rs2010963 (G > C), rs833061 (T > C), rs699947 (C > A), rs3025039 (C > T) and rs1570360 (G > A).
|
27613596 |
2017 |
|
rs699947
|
|
|
0.060 |
GeneticVariation |
BEFREE |
After adjustment for covariates, significant association of DR remained with the homozygous genotype of the minor allele for the SNPs rs699947 (odds ratio [OR] = 3.54, 95% confidence interval [CI]: 1.12-11.19), rs833061 (OR = 3.72, 95% CI: 1.17-11.85), rs13207351 (OR = 3.76, 95% CI: 1.21-11.71), and rs2146323 (OR = 2.8, 95% CI: 1.46-5.37) in the VEGF gene as well as the SNP rs2071559 (OR = 1.62, 95% CI: 1.08-2.41) in the KDR gene.
|
24623964 |
2014 |
|
rs699947
|
|
|
0.060 |
GeneticVariation |
BEFREE |
No evidence of association was observed between -2578 A/C (rs699947), +405C/G (rs2010963), +936C/T (rs3025039), and DR risk under stringent Bonferroni's correction.
|
24534217 |
2014 |
|
rs699947
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our meta-analysis confirmed the significant association between rs699947 polymorphism and DR after exclusion of outliers, and rs2010963 polymorphism might be not associated with DR.
|
24131746 |
2013 |
|
rs699947
|
|
|
0.060 |
GeneticVariation |
BEFREE |
After adjusting for covariates, a significant association of DR was observed with the homozygous genotype of the minor allele for promoter SNPs rs699947 (odds ratio (OR)=3.54, 95% confidence interval (CI): 1.12-11.19), rs833061 (OR=3.72, 95% CI: 1.17-11.85) and rs13207351 (OR=3.76, 95% CI: 1.21-11.71).
|
22162628 |
2011 |
|
rs699947
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We found a significant association between the A allele at rs699947 with DR (odds ratio = 1.84 (95% confidence interval = 1.28-2.66); P = 0.001 vs. noDR).
|
20444917 |
2010 |
|
rs2146323
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The allelic distribution of VEGF-A rs2146323 polymorphism tended to be associated with the severity of DRP (p = 0.069).
|
29030794 |
2018 |
|
rs2010963
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The VEGF gene SNPs analyzed with regard to DR susceptibility were rs2010963 (G > C), rs833061 (T > C), rs699947 (C > A), rs3025039 (C > T) and rs1570360 (G > A).
|
27613596 |
2017 |
|
rs833061
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The T allele in rs3025039 and the C allele in rs833061 are associated with increased DR susceptibility.
|
27613596 |
2017 |
|
rs2010963
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We found the frequencies of the CC, CG, and GG genotype of the rs2010963 polymorphism were 15.09%, 47.14%, and 37.74% in DR and 12.90%, 19.35%, and 67.74% in DNR, respectively (p = 0.0205).
|
27648002 |
2016 |
|
rs2146323
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our meta-analysis confirmed the association between the VEGF rs2146323 polymorphism and the risk of DR.
|
26553067 |
2015 |
|
rs2010963
|
|
|
0.040 |
GeneticVariation |
BEFREE |
No evidence of association was observed between -2578 A/C (rs699947), +405C/G (rs2010963), +936C/T (rs3025039), and DR risk under stringent Bonferroni's correction.
|
24534217 |
2014 |
|
rs2146323
|
|
|
0.040 |
GeneticVariation |
BEFREE |
After adjustment for covariates, significant association of DR remained with the homozygous genotype of the minor allele for the SNPs rs699947 (odds ratio [OR] = 3.54, 95% confidence interval [CI]: 1.12-11.19), rs833061 (OR = 3.72, 95% CI: 1.17-11.85), rs13207351 (OR = 3.76, 95% CI: 1.21-11.71), and rs2146323 (OR = 2.8, 95% CI: 1.46-5.37) in the VEGF gene as well as the SNP rs2071559 (OR = 1.62, 95% CI: 1.08-2.41) in the KDR gene.
|
24623964 |
2014 |
|
rs833061
|
|
|
0.040 |
GeneticVariation |
BEFREE |
After adjustment for covariates, significant association of DR remained with the homozygous genotype of the minor allele for the SNPs rs699947 (odds ratio [OR] = 3.54, 95% confidence interval [CI]: 1.12-11.19), rs833061 (OR = 3.72, 95% CI: 1.17-11.85), rs13207351 (OR = 3.76, 95% CI: 1.21-11.71), and rs2146323 (OR = 2.8, 95% CI: 1.46-5.37) in the VEGF gene as well as the SNP rs2071559 (OR = 1.62, 95% CI: 1.08-2.41) in the KDR gene.
|
24623964 |
2014 |
|
rs833061
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A significant relationship between VEGF+936C/T (rs3025039) polymorphism and DR was found in a recessive model (OR = 3.19, 95% CI = 1.20-8.41, and P(z) = 0.01) in Asian and overall populations, while a significant association was also found between -460T/C (rs833061) polymorphism and DR risk under a recessive model (OR = 2.12, 95% CI = 1.12-4.01, and P(z) = 0.02).CONCLUSIONS.
|
24868559 |
2014 |
|
rs2010963
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our meta-analysis confirmed the significant association between rs699947 polymorphism and DR after exclusion of outliers, and rs2010963 polymorphism might be not associated with DR.
|
24131746 |
2013 |
|
rs2146323
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A significant association of DR was also observed with haplotype ACA, as defined by minor alleles of promoter SNPs rs699947, rs833061, and rs13207351 (OR=1.52, 95% CI: 1.03-2.24), and haplotype GAA, as defined by SNPs rs2010963, rs833069, and rs2146323 (OR=1.62, 95% CI: 1.08-2.41).
|
22162628 |
2011 |
|
rs833061
|
|
|
0.040 |
GeneticVariation |
BEFREE |
After adjusting for covariates, a significant association of DR was observed with the homozygous genotype of the minor allele for promoter SNPs rs699947 (odds ratio (OR)=3.54, 95% confidence interval (CI): 1.12-11.19), rs833061 (OR=3.72, 95% CI: 1.17-11.85) and rs13207351 (OR=3.76, 95% CI: 1.21-11.71).
|
22162628 |
2011 |
|
rs3025039
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The T allele in rs3025039 and the C allele in rs833061 are associated with increased DR susceptibility.
|
27613596 |
2017 |
|
rs3025039
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A significant relationship between VEGF+936C/T (rs3025</span>039) polymorphism and DR was found in a recessive model (OR = 3.19, 95% CI = 1.20-8.41, and P(z) = 0.01) in Asian and overall populations, while a significant association was also found between -460T/C (rs833061) polymorphism and DR risk under a recessive model (OR = 2.12, 95% CI = 1.12-4.01, and P(z) = 0.02).CONCLUSIONS.
|
24868559 |
2014 |
|
rs3025039
|
|
|
0.030 |
GeneticVariation |
BEFREE |
No evidence of association was observed between -2578 A/C (rs699947), +405C/G (rs2010963), +936C/T (rs3025039), and DR risk under stringent Bonferroni's correction.
|
24534217 |
2014 |
|
rs833069
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, the VEGF-A rs833069 gene polymorphism has a clear association with the severity of diabetic retinopathy.
|
29030794 |
2018 |
|
rs13207351
|
|
|
0.020 |
GeneticVariation |
BEFREE |
After adjustment for covariates, significant association of DR remained with the homozygous genotype of the minor allele for the SNPs rs699947 (odds ratio [OR] = 3.54, 95% confidence interval [CI]: 1.12-11.19), rs833061 (OR = 3.72, 95% CI: 1.17-11.85), rs13207351 (OR = 3.76, 95% CI: 1.21-11.71), and rs2146323 (OR = 2.8, 95% CI: 1.46-5.37) in the VEGF gene as well as the SNP rs2071559 (OR = 1.62, 95% CI: 1.08-2.41) in the KDR gene.
|
24623964 |
2014 |
|
rs13207351
|
|
|
0.020 |
GeneticVariation |
BEFREE |
After adjusting for covariates, a significant association of DR was observed with the homozygous genotype of the minor allele for promoter SNPs rs699947 (odds ratio (OR)=3.54, 95% confidence interval (CI): 1.12-11.19), rs833061 (OR=3.72, 95% CI: 1.17-11.85) and rs13207351 (OR=3.76, 95% CI: 1.21-11.71).
|
22162628 |
2011 |
|
rs833069
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A significant association of DR was also observed with haplotype ACA, as defined by minor alleles of promoter SNPs rs699947, rs833061, and rs13207351 (OR=1.52, 95% CI: 1.03-2.24), and haplotype GAA, as defined by SNPs rs2010963, rs833069, and rs2146323 (OR=1.62, 95% CI: 1.08-2.41).
|
22162628 |
2011 |