Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs757075712
rs757075712
TFAM
T 0.700 GeneticVariation CLINVAR

dbSNP: rs747418061
rs747418061
APC
0.010 GeneticVariation BEFREE To ascertain whether relationship exists between the presence of APC resistance [a hypercoagulable state due to a mutation (R506Q) in the factor V gene] and the occurrence of pre-eclampsia (PE), intrauterine growth retardation (IUGR), and pregnancy bleeding complications. 9459326

1998
dbSNP: rs1217691063
rs1217691063
MTHFR
0.070 GeneticVariation BEFREE This study was undertaken to investigate whether the cytosine-to-thymine substitution at nucleotide 677 (C677T) in the 5, 10-methylenetetrahydrofolate reductase gene is a risk factor for placental vasculopathy (abruptio placentae or placental infarction with fetal growth restriction). 10819868

2000
dbSNP: rs1217691063
rs1217691063
MTHFR
0.070 GeneticVariation BEFREE Combined heterozygosity for methylenetetrahydrofolate reductase (MTHFR) mutations C677T and A1298C is associated with abruptio placentae but not with intrauterine growth restriction. 11451544

2001
dbSNP: rs397507444
rs397507444
MTHFR
0.030 GeneticVariation BEFREE A significant association could be demonstrated between mutation A1298C and both abruptio placentae and IUGR. 11451544

2001
dbSNP: rs1217691063
rs1217691063
MTHFR
0.070 GeneticVariation BEFREE Newborns who were homozygous for the MTHFR C677T variant had a decreased risk of intrauterine growth restriction (odds ratio after adjustment for mother's genotype and other confounders, 0.52 [95 percent confidence interval, 0.29 to 0.94]). 12097536

2002
dbSNP: rs1188383936
rs1188383936
F2
0.030 GeneticVariation BEFREE Newborns who were homozygous for the MTHFR C677T variant had a decreased risk of intrauterine growth restriction (odds ratio after adjustment for mother's genotype and other confounders, 0.52 [95 percent confidence interval, 0.29 to 0.94]). 12097536

2002
dbSNP: rs1217691063
rs1217691063
MTHFR
0.070 GeneticVariation BEFREE No association was found in this study between intrauterine growth restriction with abnormal umbilical blood flow and thrombophilic polymorphisms or methylenetetrahydrofolate reductase C677T. 15075078

2004
dbSNP: rs1188383936
rs1188383936
F2
0.030 GeneticVariation BEFREE No association was found in this study between intrauterine growth restriction with abnormal umbilical blood flow and thrombophilic polymorphisms or methylenetetrahydrofolate reductase C677T. 15075078

2004
dbSNP: rs1183194405
rs1183194405
F2
0.010 GeneticVariation BEFREE A single copy of a common polymorphism, Val34Leu in factor XIII, increased the risk of intrauterine growth restriction approximately 70% when the parent of origin was the father as opposed to the mother (p < 0.05). 16192348

2005
dbSNP: rs2297660
rs2297660
LRP8 ; LOC105378728
0.010 GeneticVariation BEFREE The "A" allele at rs2297660 was associated with a higher standardized birth weight and a lower risk of FGR. 16642433

2006
dbSNP: rs1341667
rs1341667
STOX1
0.010 GeneticVariation BEFREE In an isolated Dutch population, a distortion could not be demonstrated in the transmission of STOX1-Y153H variation from heterozygous mothers to offspring in 50 and 56 families with pregnancies complicated by pre-eclampsia or intrauterine growth restriction, respectively. 17617193

2007
dbSNP: rs28937590
rs28937590
BCS1L ; ZNF142
0.010 GeneticVariation BEFREE A homozygous point mutation (232A-->G) has been found as the genetic etiology for fetal growth retardation, amino aciduria, cholestasis, iron overload, lactic acidosis, and early death (GRACILE) syndrome (MIM 603358). 18386115

2008
dbSNP: rs4986790
rs4986790
TLR4
0.010 GeneticVariation BEFREE Furthermore, no significant differences were detected in the genotype, allele and haplotype frequencies of Asp299Gly and Thr399Ile TLR4 SNPs between patients with mild and severe preeclampsia, between patients with late and early onset of the disease, or between preeclamptic patients with and without fetal growth restriction. 18712040

2008
dbSNP: rs4986791
rs4986791
TLR4
0.010 GeneticVariation BEFREE Furthermore, no significant differences were detected in the genotype, allele and haplotype frequencies of Asp299Gly and Thr399Ile TLR4 SNPs between patients with mild and severe preeclampsia, between patients with late and early onset of the disease, or between preeclamptic patients with and without fetal growth restriction. 18712040

2008
dbSNP: rs1217691063
rs1217691063
MTHFR
0.070 GeneticVariation BEFREE The following number of related studies were found: studies evaluating relationships between factor V Leiden mutation and IUGR, 12 case-control and four cohort; between PT mutation and IUGR, 11 case-control and 0 cohort; and between MTHFR C677T homozygosity and IUGR, 10 case-control and two cohort. 19461414

2009
dbSNP: rs1188383936
rs1188383936
F2
0.030 GeneticVariation BEFREE The following number of related studies were found: studies evaluating relationships between factor V Leiden mutation and IUGR, 12 case-control and four cohort; between PT mutation and IUGR, 11 case-control and 0 cohort; and between MTHFR C677T homozygosity and IUGR, 10 case-control and two cohort. 19461414

2009
dbSNP: rs2536512
rs2536512
SOD3
0.010 GeneticVariation BEFREE Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction. 19108943

2009
dbSNP: rs1799983
rs1799983
NOS3
0.010 GeneticVariation BEFREE The results suggested a lack of association between the Glu298Asp gene polymorphism and pre-eclampsia without FGR in the Turkish population. 20598027

2010
dbSNP: rs1217691063
rs1217691063
MTHFR
0.070 GeneticVariation BEFREE Our aim in this study was to investigate the association between elevated homocysteine levels and the two MTHFR polymorphisms, C677T and A1298C, with several pregnancy complications such as recurrent pregnancy loss, preeclampsia, placental abruption and intrauterine growth retardation. 21577095

2011
dbSNP: rs397507444
rs397507444
MTHFR
0.030 GeneticVariation BEFREE Our aim in this study was to investigate the association between elevated homocysteine levels and the two MTHFR polymorphisms, C677T and A1298C, with several pregnancy complications such as recurrent pregnancy loss, preeclampsia, placental abruption and intrauterine growth retardation. 21577095

2011
dbSNP: rs1253103806
rs1253103806
IGF1R
0.010 GeneticVariation BEFREE Only the second compound heterozygous IGF1R mutations to be identified, the p.E121K/E234K variant is the cause of intrauterine growth retardation and the most severe postnatal growth failure described to date in a patient with IGF1R defects. 22130793

2012
dbSNP: rs187980012
rs187980012
IGF1R
0.010 GeneticVariation BEFREE We identified a family bearing a new heterozygous missense mutation at the L2 domain of IGF-IR (R431L) through an 8-year-old girl and her mother, both born with intrauterine growth retardation. 22309212

2012
dbSNP: rs318240750
rs318240750
CDKN1C
0.010 GeneticVariation BEFREE We identified the novel c.836G>[G;T] (p.Arg279Leu) mutation in a familial case of intrauterine growth retardation (IUGR) with RSS phenotype and no evidence of IMAGe. 24065356

2013
dbSNP: rs587777736
rs587777736
NOTCH1
G 0.700 GeneticVariation CLINVAR Mutations in NOTCH1 cause Adams-Oliver syndrome. 25132448

2014