|
rs12939622
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The AA genotype of rs12939622 (in the dominant model) and the AA genotype of rs4262994 (in the recessive model) caused increased susceptibility of the subjects to fever (P < .001 and P = .008, respectively).
|
31692082 |
2020 |
|
rs4262994
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The AA genotype of rs12939622 (in the dominant model) and the AA genotype of rs4262994 (in the recessive model) caused increased susceptibility of the subjects to fever (P < .001 and P = .008, respectively).
|
31692082 |
2020 |
|
rs28940580
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Their parents were heterozygous for the same mutation p.M680I, however, the mother showed severe symptoms of FMF (recurrent attacks of fever, arthralgia and arthritis, abdominal pain, thoracic pain), the father showed recurrent pustulosis prevalent on the hands and limbs, with arthralgia and abdominal pain.
|
31443670 |
2019 |
|
rs1064797245
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A de novo p.Arg756Cys mutation in ATP1A3 causes a distinct phenotype with prolonged weakness and encephalopathy triggered by fever.
|
29066118 |
2018 |
|
rs137854601
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we tested the effects of Ranolazine, the late I<sub>Na</sub> blocker, on voltage-dependent and kinetic properties of E1784K at elevated temperature and cytosolic calcium.
|
29483621 |
2018 |
|
rs1055229
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, patients with the CC genotype of rs12477677 were correlated with fewer occurrences of fever (p = 0.016), while patients carrying the T allele were associated with lower levels of ESR in the dominant model of rs1055229 (p = 0.021).
|
28424495 |
2017 |
|
rs121918622
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To test this hypothesis, we subjected 21-23-day-old mice expressing the human SCN1A GEFS+ mutation R1648H to prolonged hyperthermia, and then examined seizure and behavioral phenotypes during adulthood.
|
28373025 |
2017 |
|
rs12477677
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, patients with the CC genotype of rs12477677 were correlated with fewer occurrences of fever (p = 0.016), while patients carrying the T allele were associated with lower levels of ESR in the dominant model of rs1055229 (p = 0.021).
|
28424495 |
2017 |
|
rs1800872
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the duration of fever, white blood cell (WBC) count, C-reactive protein (CRP), neutrophils, and lymphocytes and monocytes of virus-induced encephalitis patients with IL-4 rs2227288 and IL-10 rs1800872 all displayed significant differences (all P<0.05).
|
28935853 |
2017 |
|
rs2227288
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the duration of fever, white blood cell (WBC) count, C-reactive protein (CRP), neutrophils, and lymphocytes and monocytes of virus-induced encephalitis patients with IL-4 rs2227288 and IL-10 rs1800872 all displayed significant differences (all P<0.05).
|
28935853 |
2017 |
|
rs35829419
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A 15-year-old patient with double heterozygosity for the mutations 1129G>A and 928G>A in MVK gene, heterozygosity for the mutation 2107C>A in CIAS1 gene and hyper-IgD syndrome phenotype, has been treated with anakinra with a reduction of 50% in the number of fever episodes per month, a reduction of 33% in the days of fever for each attack and normal blood tests in the intercritical phase.
|
28638818 |
2017 |
|
rs104895358
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hyper-IgD and periodic fever syndrome (HIDS) due to compound heterozygosity for G336S and V377I in a 44-year-old patient with a 27-year history of fever.
|
27899390 |
2016 |
|
rs1051266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggested that the risk of NTDs was potentially influenced by a gene-environment interaction between maternal SLC19A1 rs1051266 GG/GA genotype and first trimester fever.
|
24917213 |
2015 |
|
rs11568658
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ABCC4 single nucleotide polymorphism rs11568658 was associated with misoprostol-induced fever.
|
26122863 |
2015 |
|
rs1204135596
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A rare, c.1955G>A, p.Arg652His MEFV gene variant was identified at negligible levels in an early peripheral blood DNA sample, but affected 46 % of the MEFV alleles and was restricted to JAK2-positive, polymorphonuclear and CD3-depleted mononunuclear DNA samples obtained 4 years later, when the patient experienced fever bouts.
|
26123310 |
2015 |
|
rs766778566
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A rare, c.1955G>A, p.Arg652His MEFV gene variant was identified at negligible levels in an early peripheral blood DNA sample, but affected 46 % of the MEFV alleles and was restricted to JAK2-positive, polymorphonuclear and CD3-depleted mononunuclear DNA samples obtained 4 years later, when the patient experienced fever bouts.
|
26123310 |
2015 |
|
rs766778566
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A rare, c.1955G>A, p.Arg652His MEFV gene variant was identified at negligible levels in an early peripheral blood DNA sample, but affected 46 % of the MEFV alleles and was restricted to JAK2-positive, polymorphonuclear and CD3-depleted mononunuclear DNA samples obtained 4 years later, when the patient experienced fever bouts.
|
26123310 |
2015 |
|
rs7805622
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Through genome-wide association study (GWAS) of evoked endotoxemia (lipopolysaccharide (LPS) 1 ng/kg IV) in healthy subjects of European ancestry we discovered a locus on chr7p11.2 significantly associated with the peak febrile response to LPS (top single nucleotide polymorphism (SNP) rs7805622, P = 2.4 × 10(-12)), as well as with temperature fluctuation over time.
|
25416278 |
2015 |
|
rs1800692
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In patients with TRAPS, rs1800692 T/T homozygotes were excessively rare (p<10(-4)) and TRAPS-like patients with this genotype experienced less fever.
|
23505244 |
2014 |
|
rs1800795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome.
|
24383711 |
2014 |
|
rs2227956
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome.
|
24383711 |
2014 |
|
rs2232618
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome.
|
24383711 |
2014 |
|
rs4986790
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome.
|
24383711 |
2014 |
|
rs5743507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome.
|
24383711 |
2014 |
|
rs104895271
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The D12E substitution has been described only once to date, in a 4-year-old boy with fever.
|
23322460 |
2013 |