|
rs1732778
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant differences in genotype, allele, and haplotype frequencies for 3 OAS2 single nucleotide polymorphisms (rs1293762, rs15895, and rs1732778) and 2 OAS3 single nucleotide polymorphisms (rs2285932 and rs2072136) were detected between patients with central nervous system disease and both those with fever and/or meningitis and the control group.
|
21050126 |
2010 |
|
rs2808635
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Specifically, correlations between SNPs and different levels of PDT-V efficacy have been detected by examining the gene variants influencing (i) thrombo-coagulative pathways, i.e. methylenetetrahydrofolate reductase (MTHFR) 677C>T (rs1801133), factor V (F5) 1691G>A (rs6025), prothrombin (F2) 20210G>A (rs1799963), and factor XIII-A (F13A1) 185G>T (rs5985); (ii) complement activation and/or inflammatory processes, i.e. complement factor H (CFH) 1277T>C (rs1061170), high-temperature requirement factor A1 (HTRA1) promoter -512G>A (rs11200638), and two variants of the C-reactive protein (CRP) gene (rs2808635 and rs876538); and (iii) production and bioavailability of vascular endothelial growth factor (VEGFA -2578C>A [rs699947] and rs2146323).
|
21913742 |
2011 |
|
rs876538
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Specifically, correlations between SNPs and different levels of PDT-V efficacy have been detected by examining the gene variants influencing (i) thrombo-coagulative pathways, i.e. methylenetetrahydrofolate reductase (MTHFR) 677C>T (rs1801133), factor V (F5) 1691G>A (rs6025), prothrombin (F2) 20210G>A (rs1799963), and factor XIII-A (F13A1) 185G>T (rs5985); (ii) complement activation and/or inflammatory processes, i.e. complement factor H (CFH) 1277T>C (rs1061170), high-temperature requirement factor A1 (HTRA1) promoter -512G>A (rs11200638), and two variants of the C-reactive protein (CRP) gene (rs2808635 and rs876538); and (iii) production and bioavailability of vascular endothelial growth factor (VEGFA -2578C>A [rs699947] and rs2146323).
|
21913742 |
2011 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that patients carrying the CYP3A5*1/*3 genotype demonstrated more side effects of fever, pleural effusion, and febrile neutropenia than those with the CYP3A5*3/*3 genotype (p = 0.075, 0.077, and 0.030, respectively); moreover, patients with the ABCB1 2677G/G genotype also showed more side effects of fever and febrile neutropenia than those with other genotypes (p = 0.024 and 0.027), In regard to ABCB1 3435C>T, patients with ABCB1 3435C/C tended to suffer leucopenia (p = 0.057).
|
19332043 |
2009 |
|
rs11568658
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ABCC4 single nucleotide polymorphism rs11568658 was associated with misoprostol-induced fever.
|
26122863 |
2015 |
|
rs1554785242
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1554791280
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs11575933
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This explains the higher susceptibility of the enzymatic activity of MDTCS-P475S to reaction environments such as denaturants and high temperature.
|
23621748 |
2013 |
|
rs1064797245
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A de novo p.Arg756Cys mutation in ATP1A3 causes a distinct phenotype with prolonged weakness and encephalopathy triggered by fever.
|
29066118 |
2018 |
|
rs72554640
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs5743507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome.
|
24383711 |
2014 |
|
rs2227288
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the duration of fever, white blood cell (WBC) count, C-reactive protein (CRP), neutrophils, and lymphocytes and monocytes of virus-induced encephalitis patients with IL-4 rs2227288 and IL-10 rs1800872 all displayed significant differences (all P<0.05).
|
28935853 |
2017 |
|
rs2229291
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The F352C variant results in energy crisis at high temperature and is suspected as a risk factor for acute encephalopathy.
|
23969168 |
2014 |
|
rs2229291
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Positive association was found between rs2</span>229291 and patients with fever</span> at onset of seizure and degree of pathogenetic condition (P = 0.018 and P = 0.023), but not for rs1799821.
|
25361188 |
2014 |
|
rs1567608853
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs12939622
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The AA genotype of rs12939622 (in the dominant model) and the AA genotype of rs4262994 (in the recessive model) caused increased susceptibility of the subjects to fever (P < .001 and P = .008, respectively).
|
31692082 |
2020 |
|
rs1187636039
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the family assessed, the p.D294E mutation segregated in association with a particular sensitivity to cold exposure (especially arthralgias and myalgia), but not always with an inflammatory phenotype (e.g., urticarial rash or fever).
|
21360512 |
2011 |
|
rs755789256
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evaluation of a recombinant double mutant of staphylococcal enterotoxin B (SEB-H32Q/K173E) with enhanced antitumor activity effects and decreased pyrexia.
|
23405232 |
2013 |
|
rs3832879
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Each patient underwent evaluation of serum FGF23 levels and FGF23 genotype: the frequency of the c.212-37insC (rs3832879) polymorphism in intron 1 was examined and compared with sex, age at disease onset, fever duration, laboratory data, and occurrence of CaA.
|
24168888 |
2013 |
|
rs7849782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to univariate regression analysis, CAA formation in KD was significantly associated with fever duration (p < 0.0001), first Intravenous immunoglobulin (IVIG) used (days after day one of fever) (p < 0.0001), and the GRIN3A (rs7849782) genetic variant (p < 0.001).
|
24278430 |
2013 |
|
rs62641689
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs41550816
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evaluation of a recombinant double mutant of staphylococcal enterotoxin B (SEB-H32Q/K173E) with enhanced antitumor activity effects and decreased pyrexia.
|
23405232 |
2013 |
|
rs1057518886
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs2227956
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome.
|
24383711 |
2014 |
|
rs2069705
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of IFN-γ rs2069705 with the risk of breast cancer was not significant among all participants, while the CT/TT genotypes were significantly related to an elevated risk of breast cancer [1.32 (1.03-1.70)] among the women with <1 fever per year and to a reduced risk of breast cancer [0.63 (0.40-0.99)] among women with ≥1 fever per year compared to the CC genotype.
|
22624006 |
2012 |