|
rs4295627
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)).
|
19578367 |
2009 |
|
rs4295627
|
|
G |
0.900 |
GeneticVariation |
GWASDB |
We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)).
|
19578367 |
2009 |
|
rs4295627
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)).
|
19578367 |
2009 |
|
rs891835
|
|
G |
0.810 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies five susceptibility loci for glioma.
|
19578367 |
2009 |
|
rs891835
|
|
G |
0.810 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies five susceptibility loci for glioma.
|
19578367 |
2009 |
|
rs6470745
|
|
|
0.720 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies five susceptibility loci for glioma.
|
19578367 |
2009 |
|
rs10464870
|
|
G |
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies five susceptibility loci for glioma.
|
19578367 |
2009 |
|
rs16904140
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies five susceptibility loci for glioma.
|
19578367 |
2009 |
|
rs4295627
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our group identified 5 risk loci for glioma susceptibility (TERT rs2736100, CCDC26 rs4295627, CDKN2A/CDKN2B rs4977756, RTEL1 rs6010620, and PHLDB1 rs498872).
|
20212223 |
2010 |
|
rs4295627
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genome-wide association data have identified common genetic variants at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 11q23.3 (rs498872, PHLDB1), and 20q13.33 (rs6010620, RTEL1) as determinants of glioma risk.
|
20462933 |
2010 |
|
rs4295627
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genome-wide association studies have recently identified single-nucleotide polymorphisms (SNP) in five loci at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A/CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1) to be associated with glioma risk.
|
20847058 |
2010 |
|
rs4295627
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
rs4295627
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
rs891835
|
|
|
0.810 |
GeneticVariation |
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
rs6470745
|
|
|
0.720 |
GeneticVariation |
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
rs10464870
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
rs12544799
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
rs16904140
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
rs4636162
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
rs6985166
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
rs9656979
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
rs4295627
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Three of the gene variants (rs4295627, a variant of CCDC26; rs4977756, a variant of CDKN2A and CDKN2B; and rs6010620, a variant of RTEL1) were statistically significantly associated with glioma risk in the present population.
|
21920947 |
2011 |
|
rs6470745
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Overall, we found three protective alleles for glioma in patients: the allele "G" of rs1801275 in the IL4R gene by allele model (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.50-0.99; P=0.04) and dominant model (OR, 0.67; 95% CI, 0.46-0.99; P=0.04) analysis respectively, the allele "T" of rs17748 in the TREH gene by recessive model (OR, 0.48; 95% CI, 0.23-1.01; P=0.05) analysis, and the allele "G" of rs6470745 in CCDC26 gene by recessive model (OR, 0.48; 95% CI, 0.26-0.89; P=0.02) analysis.
|
22369735 |
2012 |
|
rs4295627
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Case-control analyses stratified into 4 molecular classes (defined by 1p-19q status, IDH mutation, and EGFR amplification) showed an association of rs4295627 and rs498872 with IDH-mutated gliomas (P < 10(-3)) and rs2736100 and rs6010620 with IDH wild-type gliomas (P < 10(-3) and P = .03).
|
23161787 |
2013 |
|
rs55705857
|
|
|
0.760 |
GeneticVariation |
BEFREE |
We also adjusted for the recently discovered 8q24 glioma risk locus rs55705857 G allele.
|
23361564 |
2013 |