|
rs2476601
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our preliminary study suggest that PTPN22:c.1858C>T gene polymorphism may be associated with a predisposition to GD within the adult north-eastern Polish population.
|
30938100 |
2019 |
|
rs2476601
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data provide the first demonstration that PTPN22 R620W confers GD susceptibility among Latin-American patients.
|
28500376 |
2017 |
|
rs2476601
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The C1858T polymorphism of the PTNP22 gene reduces the expression of its encoded LYP, which increases the risk of GD and HT.
|
28133421 |
2017 |
|
rs2476601
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphism (SNP) rs2476601 in PTPN22 is the susceptibility loci of GD in the European population.
|
24386393 |
2013 |
|
rs2476601
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Seven newly identified loci for autoimmune thyroid disease.
|
22922229 |
2012 |
|
rs2476601
|
|
|
0.900 |
GeneticVariation |
BEFREE |
(3) regarding the subtypes of AITDs, patients with Graves' disease (GD) had a significant higher degree of C1858T polymorphism (TT vs. CC, OR=2.35, 95%CI=1.36˜4.05; TC vs. CC, OR=1.46, 95%CI=1.12˜1.89; TT/TC vs. CC, OR=1.54, 95%CI=1.33˜1.80; TT vs. TC/CC, OR=2.16, 95%CI=1.25˜3.72), while no association was observed in patients with Hashimoto's thyroiditis (HT).No publication bias was observed.
|
22374238 |
2012 |
|
rs2476601
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Seven newly identified loci for autoimmune thyroid disease.
|
22922229 |
2012 |
|
rs2476601
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found a significant association between PTPN22 1858 C/T SNP and T1D and GD.
|
21467606 |
2011 |
|
rs2476601
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A missence single-nucleotide polymorphism (SNP) in the protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene known as R620W (rs2476601) was recently reported to be associated with several autoimmune diseases including Graves' disease (GD).
|
20615141 |
2010 |
|
rs2476601
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Stratifying patients affected with AITDs according to their phenotype (Graves' disease and Hashimoto's thyroiditis) and RA patients according to the presence of rheumatoid factor (RF) and antibodies against cyclic citrullinated peptides (ACPA) did not show any significant association with PTPN22 R620W allele (p>0.05).
|
19343596 |
2009 |
|
rs2476601
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The disease association of the common 1858C>T Arg620Trp (rs2476601) nonsynonymous single nucleotide polymorphism (SNP) of protein tyrosine phosphatase; nonreceptor type 22 (PTPN22) on chromosome 1p13 has been confirmed in type 1 diabetes and also in other autoimmune diseases, including rheumatoid arthritis and Graves' disease.
|
18305142 |
2008 |
|
rs2476601
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The functional (R620W) variant of human PTPN22 (protein tyrosine phosphatase non-receptor 22) gene has been implicated in the risk to several autoimmune disorders, including type 1 diabetes, Graves' disease, rheumatoid arthritis and systemic lupus erythematosus.
|
18194365 |
2008 |
|
rs2476601
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Having previously reported significant association of the T allele of rs2476601 in a Graves' disease (GD) cohort, we sought to determine whether novel rheumatoid arthritis-associated SNPs were also contributing to susceptibility to GD.
|
17148556 |
2007 |
|
rs2476601
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently, a gain of function variant C1858T of the lymphoid-specific protein tyrosine phosphatase non-receptor (LYP, PTPN22) gene has been reported to be associated with several autoimmune disorders including Graves' disease, type 1 diabetes, rheumatoid arthritis and vitiligo.
|
16893384 |
2006 |
|
rs2476601
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently, two studies on British Caucasians reported that a single nucleotide polymorphism, 1858 C > T in PTPN22, encoding Arg620Trp in the lymphoid protein tyrosine phosphatase (LYP), which is a negative regulator of T-cell activation, increases the risk of GD.
|
15943829 |
2005 |
|
rs9355610
|
|
|
0.850 |
GeneticVariation |
BEFREE |
This study was designed to unveil the association of GPR174 rs3827440, PTPN22 rs3789604, and RNASET2 rs9355610 with the onset of liver damage (LD) among the Graves' disease (GD) patients.
|
28568286 |
2018 |
|
rs9355610
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Association analysis revealed both rs6832151 located in 4p14 (odds ratio (OR) = 1.27, P <sub>Allelic</sub> = 1.48 × 10<sup>-9</sup>) and rs9355610 located in 6q27 (OR = 1.10, P <sub>Allelic</sub> = 1.04 × 10<sup>-2</sup>) was associated with GD susceptibility.
|
28521825 |
2017 |
|
rs9355610
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Our results suggest that the rs9355610 tag SNP of RNASET2 gene is positively associated with susceptibility to GD in the Chinese Han population.
|
25928629 |
2015 |
|
rs9355610
|
|
|
0.850 |
GeneticVariation |
BEFREE |
The replication of the association of the rs9355610 within 6p27 with Graves' disease.
|
24001206 |
2013 |
|
rs9355610
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Our findings are the first to show that rs6832151 and possibly rs9355610 contribute to GD pathogenesis also in Caucasians.
|
22489947 |
2012 |
|
rs9355610
|
|
G |
0.850 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies two new risk loci for Graves' disease.
|
21841780 |
2011 |
|
rs9355610
|
|
G |
0.850 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies two new risk loci for Graves' disease.
|
21841780 |
2011 |
|
rs6832151
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Association analysis revealed both rs6832151 located in 4p14 (odds ratio (OR) = 1.27, P <sub>Allelic</sub> = 1.48 × 10<sup>-9</sup>) and rs9355610 located in 6q27 (OR = 1.10, P <sub>Allelic</sub> = 1.04 × 10<sup>-2</sup>) was associated with GD susceptibility.
|
28521825 |
2017 |
|
rs6832151
|
|
|
0.830 |
GeneticVariation |
BEFREE |
However, genetic susceptibility is believed to play a major role.Recently, Chu et al. conducted a genome-wide association study in a Chinese Han population and identified two novel GD susceptibility loci within 4p14 (rs6832151) and 6q27 (rs9355610).
|
24001206 |
2013 |
|
rs6832151
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Our findings are the first to show that rs6832151</span> and possibly rs9355610 contribute to GD pathogenesis also in Caucasians.
|
22489947 |
2012 |