|
rs290487
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There were significant linear interactions between rs7903146 and BMI/WC and elevated blood glucose (P < 0.001); rs290487 and BMI/WC also showed a linear interaction with blood glucose levels (P < 0.001).
|
30718095 |
2020 |
|
rs1050828
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After recalibration of the HbA<sub>1c</sub> level taking <i>HBB</i>-rs334 and <i>G6PD</i>-rs1050828 into account, the prevalence of hyperglycemia in carriers was similar to noncarriers (31.3% vs. 28.4%, <i>P</i> = 0.28).
|
31213470 |
2019 |
|
rs1137101
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To determine whether genetic polymorphisms related to pharmacodynamics with metabolic adverse effects, namely leptin promoter (<i>LEP</i>) rs7799039, leptin receptor rs1137101, dopamine D2 rs4436578, serotonin 5-HT2A rs6313, and serotonin 5-HT2C rs518147 and rs12836771, are associated with hyperglycemia induced by risperidone or clozapine in adult Thai patients with psychosis.
|
31496784 |
2019 |
|
rs11549465
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the relative resistance of the <i>HIF-1A</i> Pro582Ser polymorphism to the repressive effect of hyperglycemia is due to the transactivation activity rather than the protein stability of HIF-1<i>α</i>.
|
31214621 |
2019 |
|
rs11932595
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, AAC, AAG, GGC and AGC (rs1801260-rs11932595-rs4580704) haplotypes were analyzed: AAG was associated with higher risk of overweight (p = 0.008), hypertriglyceridemia (p = 0.040) and hypercholesterolemia (p = 0.036); GGC with lower risk of hyperglycemia (p = 0.022), better sleep pattern (p = 0.001) and with better score at mini-mental state examination (p = 0.010); AGC with lower risk of depression (p = 0.026) and AAC with lower adherence to the MD (p = 0.028).
|
30728411 |
2019 |
|
rs12836771
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To determine whether genetic polymorphisms related to pharmacodynamics with metabolic adverse effects, namely leptin promoter (<i>LEP</i>) rs7799039, leptin receptor rs1137101, dopamine D2 rs4436578, serotonin 5-HT2A rs6313, and serotonin 5-HT2C rs518147 and rs12836771, are associated with hyperglycemia induced by risperidone or clozapine in adult Thai patients with psychosis.
|
31496784 |
2019 |
|
rs13266634
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Role of Genetic Variant rs13266634 in SLC30A8/ZnT8 in Post-Operative Hyperglycemia after Major Abdominal Surgery.
|
31220282 |
2019 |
|
rs1801260
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, AAC, AAG, GGC and AGC (rs1801260-rs11932595-rs4580704) haplotypes were analyzed: AAG was associated with higher risk of overweight (p = 0.008), hypertriglyceridemia (p = 0.040) and hypercholesterolemia (p = 0.036); GGC with lower risk of hyperglycemia (p = 0.022), better sleep pattern (p = 0.001) and with better score at mini-mental state examination (p = 0.010); AGC with lower risk of depression (p = 0.026) and AAC with lower adherence to the MD (p = 0.028).
|
30728411 |
2019 |
|
rs4436578
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To determine whether genetic polymorphisms related to pharmacodynamics with metabolic adverse effects, namely leptin promoter (<i>LEP</i>) rs7799039, leptin receptor rs1137101, dopamine D2 rs4436578, serotonin 5-HT2A rs6313, and serotonin 5-HT2C rs518147 and rs12836771, are associated with hyperglycemia induced by risperidone or clozapine in adult Thai patients with psychosis.
|
31496784 |
2019 |
|
rs4580704
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, AAC, AAG, GGC and AGC (rs1801260-rs11932595-rs4580704) haplotypes were analyzed: AAG was associated with higher risk of overweight (p = 0.008), hypertriglyceridemia (p = 0.040) and hypercholesterolemia (p = 0.036); GGC with lower risk of hyperglycemia (p = 0.022), better sleep pattern (p = 0.001) and with better score at mini-mental state examination (p = 0.010); AGC with lower risk of depression (p = 0.026) and AAC with lower adherence to the MD (p = 0.028).
|
30728411 |
2019 |
|
rs518147
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To determine whether genetic polymorphisms related to pharmacodynamics with metabolic adverse effects, namely leptin promoter (<i>LEP</i>) rs7799039, leptin receptor rs1137101, dopamine D2 rs4436578, serotonin 5-HT2A rs6313, and serotonin 5-HT2C rs518147 and rs12836771, are associated with hyperglycemia induced by risperidone or clozapine in adult Thai patients with psychosis.
|
31496784 |
2019 |
|
rs7799039
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the candidate genes, only the <i>LEP</i> rs7799039 polymorphism demonstrated a significant association with hyperglycemia</span> (χ<sup>2</sup>=9.879, <i>P</i>=0.008) in patients treated with risperidone; patients with the AA genotype had the highest risk (41.1%), followed by those with AG (20.8%) and GG (0%) genotypes.
|
31496784 |
2019 |
|
rs1018185646
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five novel (F195S, I211T, V222D, E236G and K458R) and five known (T49N, I159V, R186X, A188T and M381T) mutations were identified and co-segregated with hyperglycaemia in their pedigrees.
|
30257192 |
2018 |
|
rs104894006
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five novel (F195S, I211T, V222D, E236G and K458R) and five known (T49N, I159V, R186X, A188T and M381T) mutations were identified and co-segregated with hyperglycaemia in their pedigrees.
|
30257192 |
2018 |
|
rs1447680989
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five novel (F195S, I211T, V222D, E236G and K458R) and five known (T49N, I159V, R186X, A188T and M381T) mutations were identified and co-segregated with hyperglycaemia in their pedigrees.
|
30257192 |
2018 |
|
rs146488435
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Kcnh6 knockout (KO) or Kcnh6 p.P235L knockin (KI) mice had a phenotype characterized by changing from hypoglycemia with hyperinsulinemia to hyperglycemia with insulin deficiency.
|
30590050 |
2018 |
|
rs17817449
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also the well-known gene variants rs7903146 in TCF7L2, and rs17817449 in FTO, were nominally associated with hyperglycemia (rs7903146), as well as with higher fasting insulin levels (rs17817449).
|
30063936 |
2018 |
|
rs3856806
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As ageing and increased body fat are the signs of insulin resistance, we have studied whether the presence of Pro12Ala and C1431T of peroxisome proliferator-activated receptor gamma 2 gene and Trp64Arg of beta 3-adrenergic receptor gene may predispose to the hyperglycaemia development in postmenopausal women, who have never undergone hypoglycaemic treatment.
|
29464546 |
2018 |
|
rs4994
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping for Pro12Ala and Trp64Arg polymorphism in postmenopausal women may have the clinical benefit of predicting hyperglycaemia, thereby contributing to the prevention of diabetes mellitus development in the future.
|
29464546 |
2018 |
|
rs534828104
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We further identify a functional low-frequency human FBXW7 coding variant (p.Ala204Thr) in the Chinese population, which is associated with elevated blood glucose and T2DM risk.
|
29475832 |
2018 |
|
rs751279776
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five novel (F195S, I211T, V222D, E236G and K458R) and five known (T49N, I159V, R186X, A188T and M381T) mutations were identified and co-segregated with hyperglycaemia in their pedigrees.
|
30257192 |
2018 |
|
rs780094
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C allele of rs780094 was associated with lower lactate levels in fasting but increased lactate level during hyperglycemia independently of insulin levels.
|
30375486 |
2018 |
|
rs8004664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently, we reported that primary hepatocytes from rs8004664 hyperglycemia risk allele carriers have increased FOXN3 transcript and protein levels and liver-limited overexpression of human FOXN3, a transcriptional repressor that had not been implicated in metabolic regulation previously, increases fasting blood glucose in zebrafish.
|
29996093 |
2018 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ABCB1 rs1045642 was associated with risk of mucositis (P = 0.031), while PIK3R1 rs10515074 and RAPTOR rs9906827 were associated with hyperglycemia and non-infectious pneumonitis (P = 0.016 and 0.024, respectively).
|
28727815 |
2017 |
|
rs10515074
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ABCB1 rs1045642 was associated with risk of mucositis (P = 0.031), while PIK3R1 rs10515074 and RAPTOR rs9906827 were associated with hyperglycemia and non-infectious pneumonitis (P = 0.016 and 0.024, respectively).
|
28727815 |
2017 |