|
rs1387153
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In European populations, the rs1387153 T allele is associated with increased FPG (beta = 0.06 mmol/l, P = 7.6 x 10(-29), N = 16,094), type 2 diabetes (T2D) risk (odds ratio (OR) = 1.15, 95% CI = 1.08-1.22, P = 6.3 x 10(-5), cases N = 6,332) and risk of developing hyperglycemia or diabetes over a 9-year period (hazard ratio (HR) = 1.20, 95% CI = 1.06-1.36, P = 0.005, incident cases N = 515).
|
19060909 |
2009 |
|
rs1410713
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cox proportional hazards regression analyses showed significant associations of the CC genotype of rs6084264, the TT genotype of rs2282018, the C-allele of rs2770381, and the CC genotype of rs1410713 with the incidence of hyperglycemia.
|
27049477 |
2016 |
|
rs2770381
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cox proportional hazards regression analyses showed significant associations of the CC genotype of rs6084264, the TT genotype of rs2282018, the C-allele of rs2770381, and the CC genotype of rs1410713 with the incidence of hyperglycemia.
|
27049477 |
2016 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ABCB1 rs1045642 was associated with risk of mucositis (P = 0.031), while PIK3R1 rs10515074 and RAPTOR rs9906827 were associated with hyperglycemia and non-infectious pneumonitis (P = 0.016 and 0.024, respectively).
|
28727815 |
2017 |
|
rs1272388614
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Alternating hypoglycemia and hyperglycemia in a toddler with a homozygous p.R1419H ABCC8 mutation: an unusual clinical picture.
|
25720052 |
2015 |
|
rs1446306735
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Alternating hypoglycemia and hyperglycemia in a toddler with a homozygous p.R1419H ABCC8 mutation: an unusual clinical picture.
|
25720052 |
2015 |
|
rs59852838
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A mutation in ABCC8/SUR1, leading to a Y356C substitution in the seventh membrane-spanning alpha-helix, was observed in a patient diagnosed with hyperglycemia at age 39 years and in two adult offspring with impaired insulin secretion.
|
18346985 |
2008 |
|
rs775776658
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations.
|
21214702 |
2011 |
|
rs2241766
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only the T45G polymorphism was associated with persistent hyperglycaemia at 5 years (p=0.001).
|
16788799 |
2006 |
|
rs4994
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping for Pro12Ala and Trp64Arg polymorphism in postmenopausal women may have the clinical benefit of predicting hyperglycaemia, thereby contributing to the prevention of diabetes mellitus development in the future.
|
29464546 |
2018 |
|
rs534828104
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We further identify a functional low-frequency human FBXW7 coding variant (p.Ala204Thr) in the Chinese population, which is associated with elevated blood glucose and T2DM risk.
|
29475832 |
2018 |
|
rs671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the ALDH2 Glu504Lys polymorphism has been shown to be associated with certain traditional cardiovascular risk factors, such as dyslipidemia, hypertension, and diabetes mellitus or hyperglycemia.
|
25263942 |
2014 |
|
rs2282018
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cox proportional hazards regression analyses showed significant associations of the CC genotype of rs6084264, the TT genotype of rs2282018, the C-allele of rs2770381, and the CC genotype of rs1410713 with the incidence of hyperglycemia.
|
27049477 |
2016 |
|
rs6084264
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cox proportional hazards regression analyses showed significant associations of the CC genotype of rs6084264, the TT genotype of rs2282018, the C-allele of rs2770381, and the CC genotype of rs1410713 with the incidence of hyperglycemia.
|
27049477 |
2016 |
|
rs3738435
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no association of CHRM3 gene variant rs3738435 with BMI, and we observed no association with HbA1c or hyperglycaemia in any of the variants.
|
21336576 |
2011 |
|
rs953686324
|
|
TG |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs11932595
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, AAC, AAG, GGC and AGC (rs1801260-rs11932595-rs4580704) haplotypes were analyzed: AAG was associated with higher risk of overweight (p = 0.008), hypertriglyceridemia (p = 0.040) and hypercholesterolemia (p = 0.036); GGC with lower risk of hyperglycemia (p = 0.022), better sleep pattern (p = 0.001) and with better score at mini-mental state examination (p = 0.010); AGC with lower risk of depression (p = 0.026) and AAC with lower adherence to the MD (p = 0.028).
|
30728411 |
2019 |
|
rs4580704
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, AAC, AAG, GGC and AGC (rs1801260-rs11932595-rs4580704) haplotypes were analyzed: AAG was associated with higher risk of overweight (p = 0.008), hypertriglyceridemia (p = 0.040) and hypercholesterolemia (p = 0.036); GGC with lower risk of hyperglycemia (p = 0.022), better sleep pattern (p = 0.001) and with better score at mini-mental state examination (p = 0.010); AGC with lower risk of depression (p = 0.026) and AAC with lower adherence to the MD (p = 0.028).
|
30728411 |
2019 |
|
rs1801260
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, AAC, AAG, GGC and AGC (rs1801260-rs11932595-rs4580704) haplotypes were analyzed: AAG was associated with higher risk of overweight (p = 0.008), hypertriglyceridemia (p = 0.040) and hypercholesterolemia (p = 0.036); GGC with lower risk of hyperglycemia (p = 0.022), better sleep pattern (p = 0.001) and with better score at mini-mental state examination (p = 0.010); AGC with lower risk of depression (p = 0.026) and AAC with lower adherence to the MD (p = 0.028).
|
30728411 |
2019 |
|
rs587777042
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we report mutations (c.288G>T [p.Trp96Cys] and c.643C>T [p.Leu215Phe]) in CYC1, encoding the cytochrome c1 subunit of complex III, in two unrelated children presenting with recurrent episodes of ketoacidosis and insulin-responsive hyperglycemia.
|
23910460 |
2013 |
|
rs10139403
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In meta-analysis including additional independent Hyperglycemia and Adverse Pregnancy Outcome Study data, the association with maternally transmitted fetal DLK1 rs10139403 reached genome-wide significance (P=6.3×10<sup>-10</sup>).
|
27777362 |
2016 |
|
rs4436578
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To determine whether genetic polymorphisms related to pharmacodynamics with metabolic adverse effects, namely leptin promoter (<i>LEP</i>) rs7799039, leptin receptor rs1137101, dopamine D2 rs4436578, serotonin 5-HT2A rs6313, and serotonin 5-HT2C rs518147 and rs12836771, are associated with hyperglycemia induced by risperidone or clozapine in adult Thai patients with psychosis.
|
31496784 |
2019 |
|
rs373269573
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our findings suggest that the common Glu23Lys polymorphism in KIR6.2 is not necessarily associated with beta-cell dysfunction or insulin resistance but with diminished suppression of glucagon secretion in response to hyperglycemia.
|
12196481 |
2002 |
|
rs764437500
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our findings suggest that the common Glu23Lys polymorphism in KIR6.2 is not necessarily associated with beta-cell dysfunction or insulin resistance but with diminished suppression of glucagon secretion in response to hyperglycemia.
|
12196481 |
2002 |
|
rs8004664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently, we reported that primary hepatocytes from rs8004664 hyperglycemia risk allele carriers have increased FOXN3 transcript and protein levels and liver-limited overexpression of human FOXN3, a transcriptional repressor that had not been implicated in metabolic regulation previously, increases fasting blood glucose in zebrafish.
|
29996093 |
2018 |