|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ADD1 G460W-dominant model for the G allele was significantly associated with hypertension of IgAN patients (P = 0.001, Pc = 0.031 and OR = 1.37).
|
24271554 |
2014 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Gly460Trp variant of the alpha-adducin gene has been associated with renal sodium retention and salt-sensitive hypertension.
|
18458162 |
2008 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study examined the SNPs AGT rs699 (Met235Thr), ADD1 rs4961 (Gly460Trp), NPPA rs5063 (Val32Met), GPX1 rs1050450 (Pro198Leu), and AGTR1 rs5186 (A1166C) in relation to hypertension and salt sensitivity.
|
27480094 |
2017 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicate that the α-adducin rs4961 polymorphism may serve as a genetic biomarker of HTN in Asians.
|
30552709 |
2019 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
More studies based on a larger population are required to evaluate further the role of alpha-adducin Gly460Trp polymorphism in salt-sensitive hypertension.
|
20145305 |
2010 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggest that the Gly460Trp polymorphism of ADD-1 is not associated with hypertension.
|
15608390 |
2004 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests that the Gly460Trp polymorphism might increase the risk of hypertension in Chinese populations, especially in Han Chinese.
|
21228790 |
2011 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results rather suggest that another variant in linkage disequilibrium with the Gly460Trp polymorphism increases susceptibility for hypertension.
|
10673730 |
2000 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We recently found that femoral intima media thickness, as well as the incidence of hypertension, is influenced by genes encoding the angiotensin-converting enzyme (ACE; insertion/deletion [I/D]) polymorphism, alpha-adducin (Gly460Trp), and aldosterone synthase (-344C/T).
|
11728946 |
2001 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our case-control study and the following meta-analysis failed to provide evidence for the genetic association of alpha-adducin gene G460W polymorphism with hypertension.
|
19960031 |
2010 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A recent report by Cusi et al showed that the Trp allele of alpha-adducin polymorphism (Gly 460 Trp) is associated with an increased risk of hypertension in whites, which led us to carry out a case-control study to examine whether the same association is observed in the Japanese population.
|
9607391 |
1998 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ADD1 Gly460Trp polymorphism is associated with salt-sensitive hypertension and increased Na-K pump activity in transfected cells.
|
18667944 |
2008 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The alpha-adducin Gly460Trp polymorphism and the antihypertensive effects of exercise among men with high blood pressure.
|
17472579 |
2007 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, 3 physiologically important candidate gene mutations (angiotensinogen A[-6], alpha-Adducin Gly460Trp, and G-Protein beta(3)-subunit C825T) were examined for their association with hypertension status in a sample of 904 African Americans from Jackson, Mississippi.
|
10856280 |
2000 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additional studies have suggested that a polymorphism within exon 10 of the human alpha-adducin gene (Gly-460-Trp) may be associated with hypertension and salt sensitivity.
|
10912756 |
2000 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Hence, no evidence was found to suggest an association between either the alpha-adducin G460W or the ACE I/D polymorphism and hypertension in a careful case-control study.
|
11116113 |
2000 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An interaction with hypertension in the association between the ADD1 G460W polymorphism and cardiovascular disease merits further testing in additional populations.
|
12052841 |
2002 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additionally, the T allele of rs4961 of the ADD gene was correlated with hypertension in women (P=0.03124; OR=1.584).
|
23122309 |
2012 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Also in humans, a polymorphism of alpha-adducin gene (Gly460Trp) has been found to be significantly associated both to hypertension and salt sensitivity.
|
9678591 |
1998 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggest the possibility that the Gly460Trp polymorphism of ADD-1 is associated with low renin hypertension.
|
12195119 |
2002 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
On the other hand, the Gly460Trp genotype of the alpha-adducin gene (ADD1) is associated with erythrocyte sodium transport and increases tubular sodium reabsorption and risk for hypertension.
|
12924618 |
2003 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this short editorial review, we summarize the recent experimental, clinical and epidemiological evidence that contributed to our understanding of the pathogenetic mechanisms that lead to hypertension associated with the alpha-adducin Gly460Trp polymorphism and its interaction with ouabain.
|
16207143 |
2005 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Since inflammatory mechanisms may be involved in pathophysiology of hypertension and in endothelial dysfunction and atherosclerosis through reactive oxygen species, the baseline urinary excretion of inflammatory and oxidative stress markers in a subgroup of adolescents stratified according to <i>ADD1</i>(alpha adducin) rs4961 genotypes was assessed.
|
31760884 |
2020 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, the Gly460Trp variant was not associated with hypertension in this population.
|
15187197 |
2004 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Gly460Trp variant of the alpha-adducin gene has been associated with the salt-sensitive and diuretic responsive form of hypertension.
|
19145769 |
2009 |